Voriconazole pharmacokinetics and photosensitivity in children with cystic fibrosis

详细信息	查看全文 | 推荐本文 |

• 作者：Sophia L. Markantonis^a ; ^{kyroudi@pharm.uoa.gr} ; Anna Katelari^b ; Eleni Pappa^a ; Stavros Doudounakis^b
• 关键词：Voriconazole ; Pharmacokinetics ; Photosensitivity ; Cystic fibrosis ; Allergic bronchopulmonary aspergillosis
• 刊名：Journal of Cystic Fibrosis
• 出版年：2012
• 期刊代码：298_15691993
• 类别：med
• 出版时间：May, 2012
• 卷：11
• 期：3
• 页码：246-252
• 文件大小：440 K

摘要

Background

A high incidence of adverse skin reactions following long-term oral administration of voriconazole in children with cystic fibrosis and allergic bronchopulmonary aspergillosis (ABPA). The aim was to study the pharmacokinetics of voriconazole in these patients and to determine a possible association between drug levels and adverse effects.

Methods

Multiple venous blood samples were collected for HPLC determination of voriconazole concentrations and routine blood tests. Adverse events were recorded.

Results

No significant correlation was found between incidence of photosensitivity and voriconazole serum levels in 6 of 8 children with ABPA. 80%of patients had trough voriconazole concentrations<1000 ng/mL and were highly variable.

Conclusions

Long-term voriconazole therapy and greater sun exposure in Greece appear to play a major role in the occurrence of photosensitivity. Steady-state plasma drug concentrations were found to be highly variable and below the recommended therapeutic range in most patients, without any apparent negative influence on outcome.