The combination of 谋nterleukin-10 鈭?#xa0;1082 and tumor necrosis factor 伪 鈭?#xa0;308 or 谋nterleukin-6 鈭?#xa0;174 genes polymorphisms suggests an association with susceptibility to Hashimoto's thyroiditis

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• 作者：Merve Baki^a ; Fevziye E. Akman^a ; Pervin Vural^a ; ^{pervinvural@yahoo.com} ; Semra Do臒ru-Abbaso臒lu^a ; Ay艧enur Ö ; zderya^b ; Berrin Karada臒^b ; M&uuml ; jdat Uysal^a
• 关键词：Anti-Tg ; anti-thyroglobulin antibody ; Anti-TPO ; anti-thyroid peroxidase antibody ; BMI ; body mass index ; BP ; blood pressure ; CI ; confidence interval ; HWE ; Hardy&ndash ; Weinberg equilibrium ; HDL-C ; high density lipoproteine-cholesterol ; HT ; Hashimoto's thyro
• 刊名：International Immunopharmacology
• 出版年：2012
• 期刊代码：123_15675769
• 类别：med
• 出版时间：April, 2012
• 卷：12
• 期：4
• 页码：543-546
• 文件大小：168 K

摘要

Background

The etiopathogenesis of Hashimoto's thyroiditis (HT) has not been clearly elucidated although the role of chronical inflammation and endothelial dysfunction has been established. The imbalance between pro- and anti-inflammatory cytokines may play a role in the etiology. The aim of the present study was to investigate whether cytokine gene polymorphisms are associated with HT, and to evaluate the relationship between genotypes and clinical/laboratory manifestation of HT.

Methods

Tumor necrosis factor 伪 (TNF伪) G-308A (rs 1800629), interleukin-6 (IL-6) G-174C (rs 1800795) and IL-10 G-1082A (rs 1800896) single nucleotide polymorphisms (SNPs) in DNA from peripheral blood leukocytes of 190 patients with HT and 231 healthy controls were investigated by real-time PCR combined with melting curve analysis using fluorescence-labeled hybridization probes.

Results

There was no notable risk for HT afflicted by TNF伪 鈭?#xA0;308, IL-6 鈭?#xA0;174 and IL-10 鈭?#xA0;1082 polymorphisms alone. However, carriers of variant alleles of both IL-10 鈭?#xA0;1082 and TNF伪 鈭?#xA0;308 polymorphisms had four-fold times higher risk for HT in comparison with non-carriers. Additionally, concomitant presence of both mutant IL-10 鈭?#xA0;1082 A and IL-6 鈭?#xA0;174 C alleles raised three-fold the HT risk.

Conclusion

Our results suggest that the combined effects of TNF伪 鈭?#xA0;308, IL-6 鈭?#xA0;174 and IL-10 鈭?#xA0;1082 variant alleles may be more decisive to induce functional differences and modify the risk for HT.