Interference with withdrawal signs of naloxone-induced opiate withdrawal under anesthesia is anesthetic-specific in opiate-dependent rats

详细信息	查看全文 | 推荐本文 |

• 作者：Streel ; Emmanuel ; Dan ; Bernard ; Bredas ; Philippe ; Clement ; Bé ; atrice ; Pelc ; Isy ; Verbanck ; Paul
• 关键词：Opiate withdrawal ; Anesthesia ; Ketamine ; Midazolam ; UROD
• 刊名：Life Sciences
• 出版年：2001
• 期刊代码：62_00243205
• 类别：imm
• 出版时间：December 21, 2001
• 卷：70
• 期：5
• 页码：517-522
• 文件大小：175 K

摘要

We hypothesized that interference of opiate antagonist-precipitated withdrawal signs under anesthesia is anesthetic-specific. Three groups of morphine-dependent rats were compared in different experimental conditions using a protocol of rapid withdrawal induction by an antagonist under anesthesia. We observed that ketamine and midazolam have different effects on the expression of withdrawal. This brings specific insights into the pharmacological basis of therapy with induction of opiate antagonist.