Interaction between sex hormones and WNT/尾-catenin signal transduction in endometrial physiology and disease
- 作者：Paul H. van der Horst ; p.vanderhorst@erasmusmc.nl ; Yongyi Wang ; Marten van der Zee ; Curt W. Burger ; Leen J. Blok
- 关键词：Wnt/尾-catenin ; Endometrium ; Myometrium ; Mü ; llerian-duct ; Progesterone ; Estrogen
- 刊名：Molecular and Cellular Endocrinology
- 出版年：2012
- 期刊代码：109_03037207
- 类别：bio
- 出版时间：25 July, 2012
- 卷：358
- 期：2
- 页码：176-184
- 文件大小：499 K
摘要
Wnt/尾-catenin signalling plays a rate-limiting role in early development of many different organs in a broad spectrum of organisms. In the developing M眉llerian duct, Wnt/尾-catenin signalling is important for initiation, outgrowth, patterning and differentiation into vagina, cervix, uterus and oviducts. In adult life, sex hormones modulate Wnt/尾-catenin signalling in the endometrium to maintain the monthly balance between estrogen-induced proliferation and progesterone-induced differentiation, and enhanced Wnt/尾-catenin signalling seems to be involved in endometrial carcinogenesis. However, early in pregnancy enhanced Wnt/尾-catenin signalling is prerequisite for proper implantation and invasion of trophoblast cells into endometrium and myometrium thus helping to form a placenta. Overall, it seems that tight control of Wnt/尾-catenin signalling in time and space is important for initiation, development and normal function of the female reproductive tract. However, if Wnt/尾-catenin signalling is not kept in check, it easily seems to initiate or contribute to development of a number of uterine disorders.