Effects of environmental enrichment on exploration, anxiety, and memory in female TgCRND8 Alzheimer mice

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• 作者：Nicole G&#xf6 ; rtz ; Lars Lewejohann ; Manuel Tomm ; Oliver Ambré ; e ; Kathy Keyvani ; Werner Paulus ; Norbert Sachser
• 关键词：Alzheimer's disease (AD) ; Environmental enrichment ; TgCRND8 mice ; Learning and memory ; Barnes maze ; Object recognition memory ; Exploratory behaviour ; Anxiety-related behaviour
• 刊名：Behavioural Brain Research
• 出版年：2008
• 期刊代码：3_01664328
• 类别：neu
• 出版时间：5 August 2008
• 卷：191
• 期：1
• 页码：43-48
• 文件大小：358 K

摘要

After we could recently demonstrate a beneficial effect of environmental enrichment on AD-like brain pathology in female TgCRND8 mice [Ambrée O, Leimer U, Herring A, Görtz N, Sachser N, Heneka MT, et al. Reduction of amyloid angiopathy and Abeta plaque burden after enriched housing in TgCRND8 mice: involvement of multiple pathways. Am J Pathol 2006;169:544–52] the present study focuses on the behavioural effects of environmental enrichment with special emphasis on learning and memory performance in this AD model.