Anti-HBV activities of Streblus asper and constituents of its roots

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• 作者：Hong Chen^a ; ^b ; Jun Li^a ; ^b ; ^{lijun9593@mailbox.gxnu.edu.cn} ; Qiang Wu^b ; Xiao-Tao Niu^b ; Mao-Tong Tang^a ; ^c ; Xin-Lan Guan^d ; Jian Li^d ; Rui-Yun Yang^b ; Sheng-Ping Deng^b ; ^{Dengandping@sina.com} ; Xiao-Jian Su^a ; ^c
• 关键词：Moraceae ; Streblus asper ; (7R ; 8S ; 7&prime ; R ; 8&prime ; S)-erythro-strebluslignanol H ; Anti-HBV activity
• 刊名：Fitoterapia
• 出版年：2012
• 期刊代码：35_0367326x
• 类别：ch
• 出版时间：June, 2012
• 卷：83
• 期：4
• 页码：643-649
• 文件大小：724 K

摘要

The extracts from leaves, heartwood, barks and roots of the Streblus asper were investigated for anti-HBV activities, separately. The results suggested that the MeOH extracts of the heartwood, barks, and roots exhibited good anti-HBV activities. Further investigations displayed that ethyl acetate and n-butanol soluble parts of their MeOH extracts showed more significant anti-HBV activities. Moreover, a new lignan, together with 11 known compounds, was isolated from n-butanol-soluble part of MeOH extract of the roots of S. asper. The structures were elucidated by spectroscopic methods, including 1D NMR (¹H NMR, ¹³C NMR), 2D NMR (HMQC, HMBC) and HR-EI-MS experiments. Compounds 1-3 were evaluated for their anti-HBV activities. Honokiol showed significant anti-HBV activity with IC₅₀ values of 3.14 渭M and 4.74 渭M for HBsAg and HBeAg with no cytotoxicity respectively, while lamivudine (3TC, positive control) exhibited weak anti-HBV activity with IC₅₀ values of 11.81 渭M and 25.80 渭M for HBsAg and HBeAg respectively.