Fibroblast growth factor 20 (FGF20) polymorphism is a risk factor for Parkinson鈥檚 disease in Chinese population

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• 作者：Jing Pan^a ; ^b ; ¹ ; Hui Li^a ; ¹ ; Ying Wang^a ; Jian-Fang Ma^a ; Jin Zhang^a ; Gang Wang^a ; Jun Liu^a ; Xi-Jin Wang^a ; Qin Xiao^a ; ^{xiaoqin67@medmail.com.cn} ; Sheng-Di Chen^a ; ^b ; ^{chen_sd@medmail.com.cn}
• 关键词：Fibroblast growth factor 20 ; Polymorphism ; Parkinson&rsquo ; s disease
• 刊名：Parkinsonism and Related Disorders
• 出版年：2012
• 期刊代码：215_13538020
• 类别：med
• 出版时间：June, 2012
• 卷：18
• 期：5
• 页码：629-631
• 文件大小：118 K

摘要

The etiology of Parkinson鈥檚 disease (PD) is not well established. Genetic variation in fibroblast growth factor 20 (FGF20) might influence the risk of PD occurrence and development. In this study, Two DNA polymorphisms at genetic variation in FGF20, rs2720208 (C/T) and rs1721100 (C/G), were genotyped by direct sequencing in Han Chinese population, including 394 PD patients and 383 healthy controls. Stastistical analyses revealed that for rs1721100 (C/G) polymorphism, there were significant differences in genotype distribution between PD and healthy-matched controls. For rs12720208 (C/T) polymorphism, there was no significant difference in genotype distribution and gender and age-related differences between PD and control group. Results in this study revealed that the rs1721100(C/G) polymorphism is a risk factor for PD in Han Chinese population, while rs12720208(C/T) polymorphism is not significantly associated with PD.