RNA-binding protein Csx1 is phosphorylated by LAMMER kinase, Lkh1, in response to oxidative stress in Schizosaccharomyces pombe

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• 作者：Won-Hwa Kang ; Yoon-Dong Park ; Ji-Sook Hwang ; Hee-Moon Park
• 关键词：LAMMER kinase ; Lkh1 ; Oxidative stress ; Csx1 ; Schizosaccharomyces pombe
• 刊名：FEBS Letters
• 出版年：2007
• 期刊代码：70_00145793
• 类别：bio
• 出版时间：24 July 2007
• 卷：581
• 期：18
• 页码：3473-3478
• 文件大小：262 K

摘要

Recent studies have shown that global gene expression during oxidative stress in Schizosaccharomyces pombe is regulated by stress-induced activation and binding of Csx1 to atf1<sup>+sup> mRNA. However, the kinase responsible for the activation of Csx1 has not been identified. Here, we describe, for the first time, that Csx1 is phosphorylated by S. pombe LAMMER kinase, Lkh1, under oxidative conditions and that the stress-activated binding of the Csx1 to the atf1<sup>+sup> mRNA was also affected by Lkh1 and Spc1. These data indicate that concerted actions of Spc1 and Lkh1 are required for the activation of Csx1 during oxidative condition in the fission yeast S. pombe.