Synthesis and cytotoxicity of 1-substituted 2-methyl-1H-imidazo[4,5-g]phthalazine-4,9-dione derivatives

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• 作者：Sung Kim ; Jin ; Lee ; Hyun-Jung ; Suh ; Myung-Eun ; Choo ; Hea-Young Park ; Lee ; Sang Kook ; Park ; Hyen Joo ; et. al.
• 关键词：Imidazophthalazine ; Cytotoxicity
• 刊名：Bioorganic and Medicinal Chemistry
• 出版年：2004
• 期刊代码：9_09680896
• 类别：ch
• 出版时间：July 1, 2004
• 卷：12
• 期：13
• 页码：3683-3686
• 文件大小：268 K

摘要

A series of 1-substituted 2-methyl-1H-imidazo[4,5-g]phthalazine-4,9-dione derivatives 8 was synthesized from 6,7-dichlorophthalazine-5,8-dione 5 and evaluated for in vitro cytotoxicity against several human tumor cell lines. Most of the tested compounds showed potential cytotoxic activity considerably higher than that of the reference compounds, ellipticine and doxorubicin.