Arsenite upregulates EGR1 in HaCaT cell line

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• 作者：Min Qi ; Wei Qi Zeng ; Mihee Kim ; Zhi Min Yuan
• 关键词：Theophylline ; MK-0873 ; Interaction ; Pharmacokinetics
• 刊名：Cell Biology International
• 出版年：2008
• 期刊代码：164_10656995
• 类别：bio
• 出版时间：March 2008
• 卷：32
• 期：3
• 页码：S33
• 文件大小：43 K

摘要

MK-0873 is a novel selective phosphodiesterase-4 inhibitor, which has been in development for the treatment of chronic obstructive pulmonary disease (COPD). In this indication, theophylline is still an important treatment, despite its relatively small therapeutic window. In view of this, it is important to investigate whether MK-0873 could affect the pharmacokinetics, safety and tolerability of theophylline, when both drugs are given concomitantly.