Serum albumin is a useful prognostic indicator and adds important information to NT-proBNP in a Chinese cohort of heart failure

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• 作者：Wenting Su¹ ; Tao An¹ ; Qiong Zhou ; Yan Huang ; Jian Zhang ; ^{Zhangjian62@medmail.com.cn} ; Yuhui Zhang ; ^{yuhuizhangjoy@163.com} ; Bingqi Wei ; Xiaolu Sun ; Changhong Zou ; Kejia Lou
• 关键词：Heart failure ; Serum albumin ; Prognosis ; NT-proBNP
• 刊名：Clinical Biochemistry
• 出版年：2012
• 期刊代码：55_00099120
• 类别：med
• 出版时间：May, 2012
• 卷：45
• 期：7-8
• 页码：561-565
• 文件大小：326 K

摘要

Objective

To evaluate the effect of serum albumin on prognosis and the power of albumin adding information to NT-proBNP in a Chinese cohort of heart failure.

Design and methods

385 consecutive patients (male vs. female: 292 vs. 93; mean age: 54.89 卤 14.41 years; NYHA classes II-V) admitted for heart failure exacerbation with LVEF 鈮?#xA0;45%were enrolled, and biochemical data was measured at baseline. The endpoint was defined as cardiac death or rehospitalization for aggravated heart failure. Follow-up period was 25 卤 7 months.

Results

Multivariate analysis in a Cox proportional hazard model revealed serum albumin was an independent predictor for adverse prognosis (HR 0.96,CI 0.94-0.99, P = 0.02), and the patients with higher NT-proBNP and lower albumin than median had the highest risk for cardiac events (HR 2.89, CI 1.90-4.40, P < 0.01).

Conclusion

Serum albumin is a significant prognosis indicator for heart failure and it adds important information to NT-proBNP.