Superparamagnetic surface molecularly imprinted nanoparticles for water-soluble pefloxacin mesylate prepared via surface initiated atom transfer radical polymerization and its application in egg sample analysis

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• 作者：Yongliang Liu ; Yanyan Huang ; Jizhong Liu ; Weizhi Wang ; Guoquan Liu ; Rui Zhao ; ^{zhaorui@iccas.ac.cn}
• 关键词：Surface molecularly imprinted polymer ; Atom transfer radical polymerization ; Magnetic nanoparticles ; Pefloxacin mesylate ; Egg sample
• 刊名：Journal of Chromatography A
• 出版年：2012
• 期刊代码：47_00219673
• 类别：ch
• 出版时间：13 July, 2012
• 卷：1246
• 期：Complete
• 页码：15-21
• 文件大小：776 K

摘要

The novel superparamagnetic surface molecularly imprinted Fe₃O₄@MIP nanoparticles for water-soluble pefloxacin mesylate (PEF-M) were prepared via surface initiated atom transfer radical polymerization (si-ATRP). The binary mixture of methanol and water was selected as the polar solvents for fabricating PEF-M imprinted MIPs. The Fe₃O₄@MIP exhibited high saturation magnetization of 41.4 emu/g leading to the fast separation. The adsorption behaviors indicated that the Fe₃O₄@MIP nanoparticles possessed specific recognition and high affinity towards template PEF-M in aqueous media. Moreover, Fe₃O₄@MIP nanoparticles were directly used to selectively enrich PEF-M from egg samples. By RP-HPLC analysis, the recoveries of PEF-M were obtained as 92.8-96.5%with relative standard division of 2.4-4.0%.