Tau protein and beta-amyloid1-42 CSF levels in different phenotypes of Parkinson鈥檚 disease
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- 作者：Hana P艡ikrylov谩 Vranov谩 (1) vranovaha@seznam.cz
Jan Mare拧 (1)
Petr Hlu拧t铆k (1)
Martin Nevrl媒 (1)
David Stejskal (2)
Jana Zapletalov谩 (3)
Radko Obereigneru (4)
Petr Ka艌ovsk媒 (1) - 关键词：Parkinson’ ; s disease subgroups – ; Tau protein – ; Beta ; amyloid1 ; 42 – ; Index tau/beta – ; CSF
- 刊名：Journal of Neural Transmission
- 出版时间：March 2012
- 出版年：2012
- 期刊代码：131_0300-9564
- 类别：med
- 卷：119
- 期：3
- 页码：353-362
- 数据来源：sp
摘要
Parkinson’s disease (PD) is a neurodegenerative disorder with highly heterogeneous clinical manifestations. This fact has prompted many attempts to divide PD patients into clinical subgroups. This could lead to a better recognition of pathogenesis, improving targeted treatment and the prognosis of PD patients. The aim of the present study was to obtain cerebrospinal fluid (CSF) samples in PD patients and to search for a relationship between neurodegenerative CSF markers (tau protein, beta-amyloid1-42 and index tau protein/beta-amyloid1-42) and the clinical subtypes. PD patients were divided into three subgroups: early disease onset (EDO), tremor-dominant PD (TD-PD), and non-tremor dominant PD (NT-PD) according to the previously published classification. Neurodegenerative markers in the CSF were assessed in these three groups of patients suffering from PD (EDO-17, TD-15, NT-16 patients) and in a control group (CG) of 19 patients suffering from non-degenerative neurological diseases and 18 patients with Alzheimer’s disease (AD). The NT-PD patients were found to have significantly higher levels of CSF tau protein and index tau/beta than the control subjects and other Parkinsonian subgroups, but no significant differences in these markers were found between AD and NT-PD patients. In the context of more rapid clinical progression and more pronounced neuropathological changes in the NT-PD patient group, our results corroborate the opinion that CSF level of tau protein may be regarded as a potential laboratory marker of the presence and severity of neurodegeneration.