Prevalence of pre-malignant and malignant lesions in prophylactic mastectomy specimens of BRCA1 mutation carriers: comparison with a control group
| 详细信息 | 推荐本文 | |
- 作者：Regina Kroiss ; V. Winkler ; K. Kalteis ; D. Bikas ; M. Rudas ; M. Tea ; C. Fuerhauser ; D. Muhr ; H. Cerny and S. Glueck ; et al.
- 关键词：Breast cancer ; BRCA1 ; Prophylactic mastectomy ; Pre ; malignant lesions ; Malignant lesions
- 刊名：Journal of Cancer Research and Clinical Oncology
- 出版时间：October, 2008
- 出版年：2008
- 期刊代码：116_0171-5216
- 类别：med
- 卷：134
- 期：10
- 页码：1113-1121
- 数据来源：sp
摘要
Purpose BRCA1 mutation carriers are at high risk for breast cancer (BC). The risk management strategy may include radiological investigations for early detection or prophylactic mastectomy (PM). For a mutation carrier, PM may be more significant than surveillance alone when pre-malignant and malignant changes occur increasingly in mastectomy specimens, given normal findings on radiological investigations. In the present study we retrospectively investigated the differences between histological findings in PM specimens of BRCA1 carriers and those of a control group.