Measurements of T <sub>1sub> and T <sub>2sub> relaxation times of colon cancer metastases in rat liver at 7 T
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- 作者：G. Gambarota <SUP>A1 ; A. Veltien <SUP>A1 ; H. van Laarhoven <SUP>A2 ; M. Philippens <SUP>A3 ; A. Jonker <SUP>A4 ; O. R. Mook <SUP>A4 ; W. M. Frederiks <SUP>A4 ; A.
- 关键词：Colon cancer ; Liver metastasis ; Rat ; High-field MR ; T <sub>1sub> and T <sub>2sub> relaxation times
- 刊名：MAGMA Magnetic Resonance Materials in Physics ; Biology and Medicine
- 出版时间：December 2004
- 出版年：2004
- 期刊代码：85_0968-5243
- 类别：ph
- 卷：17
- 期：3-6
- 页码：281-287
- 数据来源：sp
摘要
The purpose of this study was to investigate the magnetic resonance imaging (MRI) characteristics of colon cancer metastases in rat liver at 7 T. A dedicated RF microstrip coil of novel design was built in order to increase the signal-to-noise ratio and, in combination with respiratory triggering, to minimize motion artifacts. T <sub>1sub>- and T <sub>2sub>-weighted MR imaging was performed to follow tumor growth. T <sub>1sub>-weighted images provided a good anatomical delineation of the liver structure, while the best contrast between metastases and normal liver tissue was achieved with T <sub>2sub>-weighted images. Measurements of T <sub>1sub> and T <sub>2sub> relaxation times were performed with inversion recovery FLASH and Carr鈥揚urcell鈥揗eiboom鈥揋ill and inversion recovery FLASH imaging sequences, respectively, for quantitative MR characterization of metastases. Both the T <sub>1sub> and T <sub>2sub> of the metastases were significantly higher than those of normal liver tissue. Further, an increase in the T <sub>1sub> relaxation time of the metastases was observed with tumor growth. These findings suggest that quantitative in vivo MR characterization provides information on tumor development and possibly response to therapy, though additional studies are needed to elucidate the correlation between the changes in relaxation times and tumor microenvironment.