Signal enhancement through heteronuclear polarisation transfer in in-vivo <sup>31sup>P MR spectroscopy of the human brain
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- 作者：W. Weber-Fahr <SUP>A1 ; P. Bachert <SUP>A2 ; F. A. Henn <SUP>A1 ; D. F. Braus <SUP>A1 ; G. Ende <SUP>A1
- 关键词：<sup>31sup>P MR spectroscopy ; Polarisation transfer ; INEPT ; Human brain ; In vivo
- 刊名：MAGMA Magnetic Resonance Materials in Physics ; Biology and Medicine
- 出版时间：May 2003
- 出版年：2003
- 期刊代码：85_0968-5243
- 类别：ph
- 卷：16
- 期：2
- 页码：68-76
- 数据来源：sp
摘要
Significant <sup>31sup>P NMR signal enhancement through heteronuclear polarisation transfer was obtained in model solutions and in vivo on a 1.5-T whole-body MR scanner equipped with two RF channels. The much higher population differences involved in proton Zeeman energy levels can be transferred to the <sup>31sup>P levels with the refocused INEPT (insensitive nucleus enhancement by polarisation transfer) double-resonance experiment by means of a series of simultaneously applied broadband RF pulses. INEPT achieves a polarisation transfer from <sup>1sup>H to <sup>31sup>P spin states by directly reordering the populations in spin systems with heteronuclear scalar coupling. Thus, only the <sup>31sup>P NMR signal of metabolites with scalar <sup>1sup>H– <sup>31sup>P coupling is amplified, while the other metabolite signals in the spectra are suppressed. Compared to Ernst-angle excitation, a repetition-time-dependent signal enhancement of ?