川芎嗪抗动脉粥样硬化的作用与机制
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摘要
动脉粥样硬化(AS)是心血管疾病死亡的主要原因,也是急性心血管病(包括心肌梗死)发病的主要原因之一,加强动脉粥样硬化的预防和治疗迫在眉睫。川芎嗪是中药川芎的有效成分之一,大量研究表明川芎嗪在治疗动脉粥样硬化方面效果显著,可以发挥保护内皮细胞、抑制血管平滑肌细胞增殖、抗血小板聚集、调节血脂浓度、抗纤维化等作用。文章综述了川芎嗪防治动脉粥样硬化的作用机制研究进展,为临床合理用药提供科学依据。
Atherosclerotic(AS) is the main cause of death of cardiovascular disease worldwide, and also one of the main causes of acute cardiovascular disease(including myocardial infarction). It is urgent to strengthen the prevention and treatment of atherosclerosis. Ligustrazine is one of the effective components of Ligusticum chuanxiong. A large number of studies have shown that ligustrazine can protect endothelial cells, inhibit the proliferation of vascular smooth muscle cells, and inhibit platelet aggregation in the treatment of atherosclerosis. Regulate the concentration of blood lipids, anti-fibrosis and so on. This article reviews the mechanism of ligustrazine in preventing and treating atherosclerosis and provides scientific basis for rational drug use in clinic.
Atherosclerotic(AS) is the main cause of death of cardiovascular disease worldwide, and also one of the main causes of acute cardiovascular disease(including myocardial infarction). It is urgent to strengthen the prevention and treatment of atherosclerosis. Ligustrazine is one of the effective components of Ligusticum chuanxiong. A large number of studies have shown that ligustrazine can protect endothelial cells, inhibit the proliferation of vascular smooth muscle cells, and inhibit platelet aggregation in the treatment of atherosclerosis. Regulate the concentration of blood lipids, anti-fibrosis and so on. This article reviews the mechanism of ligustrazine in preventing and treating atherosclerosis and provides scientific basis for rational drug use in clinic.
引文
[1] 姜宇懋,王丹巧.川芎嗪药理作用研究进展[J].中国现代中药,2016,18(10):1364.
[2] 杨敏,李慧,朱博文,等.川芎嗪抑制血管重塑的研究进展[J].中国中西医结合杂志,2018,38(3):379.
[3] Sun MY,Zhang M,Chen SL,et al.The Influence of Hyperlipidemia on Endothelial Function of FPN1 Tek-Cre Mice and the Intervention Effect of Tetramethylpyrazine[J].Cell Physiol Biochem,2018;47(1):119.
[4] Yamagata K .Docosahexaenoic acid regulates vascular endothelial cell function and prevents cardiovascular disease[J].Lipids Health Dis,2017,16(1):118.
[5] 徐也鲁.动脉粥样硬化——一种慢性炎症过程[J].中国动脉硬化杂志,2001,9(2):93.
[6] Yang C,Xu Y,Zhou H,et al.Tetramethylpyrazine protects CoCl2-induced apoptosis in human umbilical vein endothelial cells by regulating the PHD2/HIF/1a-VEGF pathway[J].Mol Med Rep,2015,13(2):1287.
[7] Wu H J,Hao J,Wang S Q,et al.Protective effects of ligustrazine on TNF-α-induced endothelial dysfunction.[J].Eur J Pharmacol,2012,674(2-3):365.
[8] Mak SK,Yu CM,Sun WT,et al.Tetramethylpyrazine suppresses angiotensin II-induced soluble epoxide hydrolase expression in coronary endothelium via anti-ER stress mechanism.[J].Toxicol Appl Pharmacol,2017,336:84.
[9] Wang GF,Shi CG,Sun MZ,et al.Tetramethylpyrazine attenuates atherosclerosis development and protects endothelial cells from ox-LDL[J].Cardiovasc Drugs Ther,2013,27(3):199.
[10] Zhang MJ,Zhou Y,Chen L,et al.An overview of potential molecular mechanisms involved in VSMC phenotypic modulation[J].Histochem Cell Biol,2016,145(2):119.
[11] 杨敏,李慧,朱博文,等.川芎嗪抑制血管重塑的研究进展[J].中国中西医结合杂志,2018,38(3):379.
[12] Ren XY,Ruan QR,Zhu DH,et al.Tetramethylpyrazine inhibits agiontensin II-induced nuclear factor-kappaB activation and bone morphogenetic protein-2 downregulation in rat vascular smooth muscle cells[J].Acta Physiol Sin,2007,59(3):339.
[13] 杨敏.川芎嗪对CaMKⅡδ促大鼠血管重塑作用的影响[D].山西省中医药研究院硕士学位论文,2017.
[14] 华军益,何煜舟,蒋旭宏,等.川芎嗪抑制血管平滑肌细胞增殖及胶原合成的作用机制研究[J].中国中西医结合杂志,2013,33(9):1226.
[15] Wong KL ,Wu KC ,Wu RS ,et al.Tetramethylpyrazine inhibits angiotensin II-increased NAD(P)H oxidase activity and subsequent proliferation in rat aortic smooth muscle cells[J].Am J Chin Med,2007,35(6):1021.
[16] Menter DG,Kopetz S,Hawk E,et al.Platelet “first responders” in wound response,cancer,and metastasis[J] Cancer Metastasis Rev,2017,36(2):199.
[17] Li L,Chen H,Shen A,et al.Ligustrazine?inhibits?platelet?activation via suppression of the Akt pathway[J].Int J Mol Med,2019,43(1):575.
[18] Cai X,Chen Z,Pan X,et al.Inhibition of angiogenesis,fibrosis and thrombosis by tetramethylpyrazine:mechanisms contributing to the SDF-1/CXCR4 axis[J].Plos One,2014,9(2):e88176.
[19] 李力.基于miRNA及其相关信号通路调控研究川芎嗪抑制血小板活化的作用机制[D].福建中医药大学博士学位论文,2018.
[20] Blair HC ,Sepulveda J ,Papachristou DJ .Nature and Nurture in Atherosclerosis:The Roles of Acylcarnitine and Cell Membrane-Fatty Acid Intermediates[J].Vasc Pharmacol,2016,78:17.
[21] Zhang Y,Ren P,Kang Q,et al.Effect of Tetramethylpyrazine on atherosclerosis and SCAP/ SREBP-1c signaling pathway in ApoE-/- mice fed with a high-fat diet[J].Evid Based Complement Alternat Med,2017,2017(3):3121989.
[22] Chen J,Tian J,Ge H,et al.Effects of tetramethylpyrazine from Chinese black vinegar on antioxidant and hypolipidemia activities in HepG2 cells.[J].Food Chem Toxicol,2017,109(Pt 2).:930.
[23] Duan J,Xiang D,Luo H,et al.Tetramethylpyrazine suppresses lipid accumulation in macrophages via upregulation of the ATP-binding cassette transporters and downregulation of scavenger receptors[J].Oncol Rep,2017,38(4):2267.
[24] 祝骥,腾耀红,王萍儿,等.川芎嗪对泡沫细胞胆固醇逆转运的影响[J].中国中药杂志,2014,39(7):1255.
[25] 聂虎,冉旭,曾智.川芎嗪对Nogo基因调控心机成纤维细胞增殖作用的影响[J].四川大学学报(医学版),2012,43(6):843.
[26] Wang C,Li Y,Yang X,et al.Tetramethylpyrazine and Astragaloside IV Synergistically Ameliorate Left Ventricular Remodeling and Preserve Cardiac Function in a Rat Myocardial Infarction Model[J].J Cardiovasc Pharmacol,2017,69(1):34.
[27] 常煜胤,路明,卢太苓,等.川芎嗪对血管紧张素Ⅱ诱导大鼠心脏成纤维细胞纤维化的影响[J].中西医结合心脑血管病杂志,2016,14(23):2758.
[2] 杨敏,李慧,朱博文,等.川芎嗪抑制血管重塑的研究进展[J].中国中西医结合杂志,2018,38(3):379.
[3] Sun MY,Zhang M,Chen SL,et al.The Influence of Hyperlipidemia on Endothelial Function of FPN1 Tek-Cre Mice and the Intervention Effect of Tetramethylpyrazine[J].Cell Physiol Biochem,2018;47(1):119.
[4] Yamagata K .Docosahexaenoic acid regulates vascular endothelial cell function and prevents cardiovascular disease[J].Lipids Health Dis,2017,16(1):118.
[5] 徐也鲁.动脉粥样硬化——一种慢性炎症过程[J].中国动脉硬化杂志,2001,9(2):93.
[6] Yang C,Xu Y,Zhou H,et al.Tetramethylpyrazine protects CoCl2-induced apoptosis in human umbilical vein endothelial cells by regulating the PHD2/HIF/1a-VEGF pathway[J].Mol Med Rep,2015,13(2):1287.
[7] Wu H J,Hao J,Wang S Q,et al.Protective effects of ligustrazine on TNF-α-induced endothelial dysfunction.[J].Eur J Pharmacol,2012,674(2-3):365.
[8] Mak SK,Yu CM,Sun WT,et al.Tetramethylpyrazine suppresses angiotensin II-induced soluble epoxide hydrolase expression in coronary endothelium via anti-ER stress mechanism.[J].Toxicol Appl Pharmacol,2017,336:84.
[9] Wang GF,Shi CG,Sun MZ,et al.Tetramethylpyrazine attenuates atherosclerosis development and protects endothelial cells from ox-LDL[J].Cardiovasc Drugs Ther,2013,27(3):199.
[10] Zhang MJ,Zhou Y,Chen L,et al.An overview of potential molecular mechanisms involved in VSMC phenotypic modulation[J].Histochem Cell Biol,2016,145(2):119.
[11] 杨敏,李慧,朱博文,等.川芎嗪抑制血管重塑的研究进展[J].中国中西医结合杂志,2018,38(3):379.
[12] Ren XY,Ruan QR,Zhu DH,et al.Tetramethylpyrazine inhibits agiontensin II-induced nuclear factor-kappaB activation and bone morphogenetic protein-2 downregulation in rat vascular smooth muscle cells[J].Acta Physiol Sin,2007,59(3):339.
[13] 杨敏.川芎嗪对CaMKⅡδ促大鼠血管重塑作用的影响[D].山西省中医药研究院硕士学位论文,2017.
[14] 华军益,何煜舟,蒋旭宏,等.川芎嗪抑制血管平滑肌细胞增殖及胶原合成的作用机制研究[J].中国中西医结合杂志,2013,33(9):1226.
[15] Wong KL ,Wu KC ,Wu RS ,et al.Tetramethylpyrazine inhibits angiotensin II-increased NAD(P)H oxidase activity and subsequent proliferation in rat aortic smooth muscle cells[J].Am J Chin Med,2007,35(6):1021.
[16] Menter DG,Kopetz S,Hawk E,et al.Platelet “first responders” in wound response,cancer,and metastasis[J] Cancer Metastasis Rev,2017,36(2):199.
[17] Li L,Chen H,Shen A,et al.Ligustrazine?inhibits?platelet?activation via suppression of the Akt pathway[J].Int J Mol Med,2019,43(1):575.
[18] Cai X,Chen Z,Pan X,et al.Inhibition of angiogenesis,fibrosis and thrombosis by tetramethylpyrazine:mechanisms contributing to the SDF-1/CXCR4 axis[J].Plos One,2014,9(2):e88176.
[19] 李力.基于miRNA及其相关信号通路调控研究川芎嗪抑制血小板活化的作用机制[D].福建中医药大学博士学位论文,2018.
[20] Blair HC ,Sepulveda J ,Papachristou DJ .Nature and Nurture in Atherosclerosis:The Roles of Acylcarnitine and Cell Membrane-Fatty Acid Intermediates[J].Vasc Pharmacol,2016,78:17.
[21] Zhang Y,Ren P,Kang Q,et al.Effect of Tetramethylpyrazine on atherosclerosis and SCAP/ SREBP-1c signaling pathway in ApoE-/- mice fed with a high-fat diet[J].Evid Based Complement Alternat Med,2017,2017(3):3121989.
[22] Chen J,Tian J,Ge H,et al.Effects of tetramethylpyrazine from Chinese black vinegar on antioxidant and hypolipidemia activities in HepG2 cells.[J].Food Chem Toxicol,2017,109(Pt 2).:930.
[23] Duan J,Xiang D,Luo H,et al.Tetramethylpyrazine suppresses lipid accumulation in macrophages via upregulation of the ATP-binding cassette transporters and downregulation of scavenger receptors[J].Oncol Rep,2017,38(4):2267.
[24] 祝骥,腾耀红,王萍儿,等.川芎嗪对泡沫细胞胆固醇逆转运的影响[J].中国中药杂志,2014,39(7):1255.
[25] 聂虎,冉旭,曾智.川芎嗪对Nogo基因调控心机成纤维细胞增殖作用的影响[J].四川大学学报(医学版),2012,43(6):843.
[26] Wang C,Li Y,Yang X,et al.Tetramethylpyrazine and Astragaloside IV Synergistically Ameliorate Left Ventricular Remodeling and Preserve Cardiac Function in a Rat Myocardial Infarction Model[J].J Cardiovasc Pharmacol,2017,69(1):34.
[27] 常煜胤,路明,卢太苓,等.川芎嗪对血管紧张素Ⅱ诱导大鼠心脏成纤维细胞纤维化的影响[J].中西医结合心脑血管病杂志,2016,14(23):2758.
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