正交试验优化凤丹皮中单萜苷的煎煮工艺
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摘要
目的:优化凤丹皮中单萜苷的煎煮工艺。方法:以氧化芍药苷、芍药苷、苯甲酰芍药苷和浸膏得率为评价指标,采用正交试验设计对凤丹皮中单萜苷的煎煮工艺进行优化。结果:最佳煎煮工艺条件为加15倍量的水,浸泡10 min,煎煮3次,每次15 min。结论:此优化的煎煮工艺稳定,合理。
Objective To optimize the decoction technology for monoterpene glycosides in Cortex Moutan. Methods Using the contents of oxypaeoniflorin,paeoiflorin,benzoylpaeoniflrin and extract yield as parameters,the decoction technology of monoterpene glycosides in Cortex Moutan was optimized by orthogonal design. Results The optimum decocting conditions were as follows: adding 15 times of water,soaking for 10 minutes,and decocting three times with 15 minutes each time.Conclusions The optimized decoction process is stable and reasonable.
Objective To optimize the decoction technology for monoterpene glycosides in Cortex Moutan. Methods Using the contents of oxypaeoniflorin,paeoiflorin,benzoylpaeoniflrin and extract yield as parameters,the decoction technology of monoterpene glycosides in Cortex Moutan was optimized by orthogonal design. Results The optimum decocting conditions were as follows: adding 15 times of water,soaking for 10 minutes,and decocting three times with 15 minutes each time.Conclusions The optimized decoction process is stable and reasonable.
引文
[1]国家药典委员会.中华人民共和国药典:一部[S].2015版.北京:中国医药科技出版社,2015:172.
[2]王新娣,石晓峰,王斌利,等.牡丹化学成分的研究进展[J].中成药,2018,40(1):171-176.
[3]徐晓燕,李颖,王伟,等.丹皮总苷对心肌缺血损伤小鼠的保护作用[J].医药导报,2015,34(9):1158-1 161.
[4]李盈,王举涛,刘金旗,等.HPLC法测定牡丹皮中芍药苷和氧化芍药苷含量[J].亚太传统医药,2016,12(21):25-27.
[5]王培,赵宏苏,吴德玲,等.正交试验-多指标归一化法优化凤丹皮水提工艺[J].中国药房,2018,29(3):361-364.
[6]俞年军,吴德玲,王艳华,等.高效液相色谱法同时测定丹皮总苷部位3种单萜苷类[J].中国医院药学杂志,2013,33(11):769-770.
[7]孟庆焕,祖元刚,王化,等.牡丹种皮中芍药苷和丹皮酚的优化提取工艺[J].安徽农业科学,2015,43(17):68-71.
[8]张晓东,唐进法,李学林.不同煎煮时间凤丹皮汤液中丹皮酚和芍药苷含量变化分析[J].中医研究,2009,22(6):18-19.
[2]王新娣,石晓峰,王斌利,等.牡丹化学成分的研究进展[J].中成药,2018,40(1):171-176.
[3]徐晓燕,李颖,王伟,等.丹皮总苷对心肌缺血损伤小鼠的保护作用[J].医药导报,2015,34(9):1158-1 161.
[4]李盈,王举涛,刘金旗,等.HPLC法测定牡丹皮中芍药苷和氧化芍药苷含量[J].亚太传统医药,2016,12(21):25-27.
[5]王培,赵宏苏,吴德玲,等.正交试验-多指标归一化法优化凤丹皮水提工艺[J].中国药房,2018,29(3):361-364.
[6]俞年军,吴德玲,王艳华,等.高效液相色谱法同时测定丹皮总苷部位3种单萜苷类[J].中国医院药学杂志,2013,33(11):769-770.
[7]孟庆焕,祖元刚,王化,等.牡丹种皮中芍药苷和丹皮酚的优化提取工艺[J].安徽农业科学,2015,43(17):68-71.
[8]张晓东,唐进法,李学林.不同煎煮时间凤丹皮汤液中丹皮酚和芍药苷含量变化分析[J].中医研究,2009,22(6):18-19.