基于不孕症临床病证特征的动物模型分析
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摘要
目前,不孕症虽然有多种建模方法,但均存在不足之处,而动物模型应用也存在一定局限性。不孕症动物模型多因病因模拟单一而无法与临床病证变化完全一致,一些模型仅通过"病"来复制模型,单从西医角度入手,虽成模率高,但忽略了中医学"证候",不能体现中医药的治疗优势。这些建模方法其实都侧重于不同的病因学,均有着各自的独特性和局限性。所以,进一步探索能反应不孕症病证特征,体现不孕症中西医病因,复制出能更加贴近临床病证特点的动物模型是今后需要努力发展的方向。
At present,although there are many kinds of modeling methods of infertility,but there are shortcomings,and the application of animal model also has some limitations. The animal model of infertility due to causes and clinical symptoms and cannot simulate a single change in exactly the same,some models to copy the model only through the " disease",a single from the western perspective,although the incidence of diabetes high,but ignores the TCM syndromes,TCM treatment can not reflect the advantages. These modeling methods are focused on different etiology,which have respective uniqueness and limitations. Therefore,further exploration the characteristics of the symptoms of infertility,reflecting the cause of infertility in Chinese and western medicine,replication more closely related to the clinical characteristics of the animal model is the future direction need to work hard.
At present,although there are many kinds of modeling methods of infertility,but there are shortcomings,and the application of animal model also has some limitations. The animal model of infertility due to causes and clinical symptoms and cannot simulate a single change in exactly the same,some models to copy the model only through the " disease",a single from the western perspective,although the incidence of diabetes high,but ignores the TCM syndromes,TCM treatment can not reflect the advantages. These modeling methods are focused on different etiology,which have respective uniqueness and limitations. Therefore,further exploration the characteristics of the symptoms of infertility,reflecting the cause of infertility in Chinese and western medicine,replication more closely related to the clinical characteristics of the animal model is the future direction need to work hard.
引文
[1]黄荷凤,王波,朱依敏,等.不孕症的规范化诊疗[J].中国实用妇科与产科杂志,2013,29(9):688-689.
[2]王雅红.输卵管造影检查在诊断妇科不孕症中的临床应用价值[J].临床研究,2013,51(4):48-50.
[3]顾仁艳,郑茜,张春,等.苯酚糊剂致大鼠血瘀型输卵管阻塞性不孕症模型制作[J].四川中医,2015,33(8):45-46.
[4]谭毅,冯德勇.中医药治疗男性不育症思路和方法的研究进展[J].中华中医药学刊,2010,28(11):2258-2260.
[5]刘燕,邹小娟,陈家旭,等.基于内容分析法的不孕症中医证候文献研究[J].中华中医药杂志,2015,30(7):2345-2348.
[6]崔阳阳,孙伟伟,赵瑞华,等.子宫内膜异位症动物模型研究进展[J].中国实验动物学报,2013,21(5):87-88.
[7]伊家嘉,夏炜.子宫移植的研究现状[J].中国美容医学,2012,21(11):2083-2084.
[8]刘丹彤,马小娜,王庆国,等.子宫内膜异位症气滞血瘀证大鼠模型的建立及评价[J].中医药学报,2012,40(2):31-34.
[9]王芳军,吕江,王晓东,等.多模式输卵管性不孕症模型制作与初步应用研究[J].中华临床医师杂志,2015,9(10):1975-1976.
[10]张丽娟,陶仕英,赵丕文,等.顺铂建立大鼠卵巢早衰动物模型的实验研究[J].世界中医药,2015,10(10):1563-1569.
[11]姚莉娟,徐晓娟.体现中医病因病机的多囊卵巢综合征动物模型评价及筛选[J].世界科学技术——中医药现代化,2014,16(10):2137-3139.
[12]陈晶晶.免疫性不孕症的中医临床研究进展[J].中医药通报,2011,10(5):64-66.
[13]曾静,黄桂晓,黄树声,等.精索静脉曲张Marmar术式的解剖学基础研究[J].热带医学杂志,2012,12(6):747-749.
[14]金济云,夏亲华.子宫内膜异位症动物模型研究进展[J].中国医药导报,2016,13(5):28-30.
[15]成杰,丁利军,胡娅莉,等.卵巢早衰动物模型制备研究进展[J].中国比较医学杂志,2013,23(4):66-69.
[16]Jagarlamudi K,Reddy P,Adhikari D,et al.Genetically modified mouse models for premature ovarian failure(POF)[J].Mol Cell Endocrinol,2010,315(1-2):1-10.
[17]Yu JJ,Xu YM,Tao Y.The comparison of two experimental rat varicocele models and their effect on sperm quality[J].Urol Int,2011,86(3):325-329.
[18]赵少英,许二平.中医药防治多囊卵巢综合征研究述评[J].中医学报,2016,31(3):419-422.
[19]李巍巍,侯丽辉,郝松莉,等.多囊卵巢综合征动物模型构建与评价[J].世界中西医结合杂志,2011,6(10):913-915.
[2]王雅红.输卵管造影检查在诊断妇科不孕症中的临床应用价值[J].临床研究,2013,51(4):48-50.
[3]顾仁艳,郑茜,张春,等.苯酚糊剂致大鼠血瘀型输卵管阻塞性不孕症模型制作[J].四川中医,2015,33(8):45-46.
[4]谭毅,冯德勇.中医药治疗男性不育症思路和方法的研究进展[J].中华中医药学刊,2010,28(11):2258-2260.
[5]刘燕,邹小娟,陈家旭,等.基于内容分析法的不孕症中医证候文献研究[J].中华中医药杂志,2015,30(7):2345-2348.
[6]崔阳阳,孙伟伟,赵瑞华,等.子宫内膜异位症动物模型研究进展[J].中国实验动物学报,2013,21(5):87-88.
[7]伊家嘉,夏炜.子宫移植的研究现状[J].中国美容医学,2012,21(11):2083-2084.
[8]刘丹彤,马小娜,王庆国,等.子宫内膜异位症气滞血瘀证大鼠模型的建立及评价[J].中医药学报,2012,40(2):31-34.
[9]王芳军,吕江,王晓东,等.多模式输卵管性不孕症模型制作与初步应用研究[J].中华临床医师杂志,2015,9(10):1975-1976.
[10]张丽娟,陶仕英,赵丕文,等.顺铂建立大鼠卵巢早衰动物模型的实验研究[J].世界中医药,2015,10(10):1563-1569.
[11]姚莉娟,徐晓娟.体现中医病因病机的多囊卵巢综合征动物模型评价及筛选[J].世界科学技术——中医药现代化,2014,16(10):2137-3139.
[12]陈晶晶.免疫性不孕症的中医临床研究进展[J].中医药通报,2011,10(5):64-66.
[13]曾静,黄桂晓,黄树声,等.精索静脉曲张Marmar术式的解剖学基础研究[J].热带医学杂志,2012,12(6):747-749.
[14]金济云,夏亲华.子宫内膜异位症动物模型研究进展[J].中国医药导报,2016,13(5):28-30.
[15]成杰,丁利军,胡娅莉,等.卵巢早衰动物模型制备研究进展[J].中国比较医学杂志,2013,23(4):66-69.
[16]Jagarlamudi K,Reddy P,Adhikari D,et al.Genetically modified mouse models for premature ovarian failure(POF)[J].Mol Cell Endocrinol,2010,315(1-2):1-10.
[17]Yu JJ,Xu YM,Tao Y.The comparison of two experimental rat varicocele models and their effect on sperm quality[J].Urol Int,2011,86(3):325-329.
[18]赵少英,许二平.中医药防治多囊卵巢综合征研究述评[J].中医学报,2016,31(3):419-422.
[19]李巍巍,侯丽辉,郝松莉,等.多囊卵巢综合征动物模型构建与评价[J].世界中西医结合杂志,2011,6(10):913-915.
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