Ⅲ型干扰素抵抗寨卡病毒感染导致不良妊娠的机制
|
摘要
寨卡病毒是一种蚊媒黄病毒,妊娠早期妇女感染寨卡病毒可引起新生儿小头畸形、胎儿宫内发育迟缓及胎儿自发性流产等不良妊娠。人胎盘原代滋养细胞分泌的Ⅲ型干扰素及Ⅲ型干扰素诱导产生的干扰素刺激基因可在细胞中建立抗病毒状态,保护胎儿免受寨卡病毒的感染。Ⅲ型干扰素对寨卡病毒导致的不良妊娠保护作用具有阶段特异性,对妊娠早期没有保护作用。本文就寨卡病毒导致不良妊娠和Ⅲ型干扰素抵抗寨卡病毒感染等方面的机制研究进行综述,为深入了解寨卡病毒致病机制和免疫预防提供参考。
Zika virus(ZIKV) is a mosquito-borne flavivirus which can cause neonatal microcephaly, intrauterine growth retardation and fetal spontaneous abortion. Interferon λ(IFN-λ) released from placenta primary human trophoblast cells and interferon-stimulated genes(ISGs) induced by IFN-λ can establish antiviral status in cells and protect fetuses from Zika virus infection. Besides, the protection of IFN-λ is gestational stage-dependent, and it does not work during early pregnancy. In this paper, the study on mechanism of IFN-λ resistance against Zika virus are reviewed in order to provide references for further understanding of the pathogenic mechanism and immune prevention of Zika virus.
Zika virus(ZIKV) is a mosquito-borne flavivirus which can cause neonatal microcephaly, intrauterine growth retardation and fetal spontaneous abortion. Interferon λ(IFN-λ) released from placenta primary human trophoblast cells and interferon-stimulated genes(ISGs) induced by IFN-λ can establish antiviral status in cells and protect fetuses from Zika virus infection. Besides, the protection of IFN-λ is gestational stage-dependent, and it does not work during early pregnancy. In this paper, the study on mechanism of IFN-λ resistance against Zika virus are reviewed in order to provide references for further understanding of the pathogenic mechanism and immune prevention of Zika virus.
引文
[1] Zhou P, Wang J, Zheng Y, et al. Zika virus may affect the universal two-child policy: a new challenge for China[J]. PLoS Negl Trop Dis, 2016, 10(11):e0004984. DOI:10.1371/journal.pntd.0004984
[2] Rubin EJ, Greene M F,Baden LR. Zika virus and microcephaly[J]. N Engl J Med, 2016, 374(10): 984-985. DOI:10.1056/NEJMe1601862
[3] Schuler-Faccini L, Ribeiro EM, Feitosa IM, et al. Possible association between Zika virus infection and microcephaly - Brazil, 2015[J]. MMWR, 2016, 65(3):59-62. DOI: 10.15585/mmwr.mm6503e2
[4] Oliveira Melo AS, Malinger G, Ximenes R, et al. Zika virus intrauterine infection causes fetal brain abnormality and microcephaly: tip of the iceberg[J]. Ultrasound Obstet Gynecol, 2016, 47(1): 6-7. DOI:10.1002/uog.15831
[5] Martines RB, Bhatnagar J, Keating MK, et al. Notes from the field: evidence of Zika virus infection in Brain and placental tissues from two congenitally infected newborns and two fetal losses-Brazil, 2015[J]. MMWR, 2016, 65(6):159-160. DOI:10.15585/mmwr.mm6506e1
[6] Xiang B, Gao P, Kang Y, et al. Importation of Zika virus in China: a significant risk in southern China[J]. J Infect, 2017, 74(3): 328-330. DOI:10.1016/j.jinf.2017.01.004
[7] Wells MF, Salick MR, Wiskow O, et al. Genetic ablation of AXL does not protect human neural progenitor cells and cerebral organoids from Zika virus infection[J]. Cell Stem Cell, 2016, 19(6): 703-708. DOI:10.1016/j.stem.2016.11.011
[8] Hamel R, Dejarnac O, Wichit S, et al. Biology of Zika virus infection in human skin cells[J]. J Virol, 2015, 89(17): 8880-8896. DOI:10.1128/JVI.00354-15
[9] Kotenko SV, Gallagher G, Baurin VV, et al. IFN-lambdas mediate antiviral protection through a distinct class II cytokine receptor complex[J]. Nat Immunol, 2003, 4(1): 69-77. DOI:10.1038/ni875
[10] Hamming OJ, Terczynska-Dyla E, Vieyres G, et al. Interferon lambda 4 signals via the IFNlambda receptor to regulate antiviral activity against HCV and coronaviruses[J]. EMBO J, 2013, 32(23): 3055-3065. DOI:10.1038/emboj.2013.232
[11] Hernandez PP, Mahlakoiv T, Yang I, et al. Interferon-lambda and interleukin 22 act synergistically for the induction of interferon-stimulated genes and control of rotavirus infection[J]. Nat Immunol, 2015, 16(7): 698-707. DOI:10.1038/ni.3180
[12] Kane M, Yadav SS, Bitzegeio J, et al. MX2 is an interferon-induced inhibitor of HIV-1 infection[J]. Nature, 2013, 502(7472): 563-566. DOI:10.1038/nature12653
[13] Liu SY, Aliyari R, Chikere K, et al. Interferon-inducible cholesterol-25-hydroxylase broadly inhibits viralentry by production of 25-hydroxycholesterol[J]. Immunity, 2013, 38(1): 92-105. DOI:10.1016/j.immuni.2012.11.005
[14] Chen J, Liang Y, Yi P, et al. Outcomes of congenital Zika disease depend on timing of infection and maternal-fetal interferon action[J]. Cell Rep, 2017, 21(6):1588-1599. DOI:10.1016/j.celrep.2017.10.059
[15] Bayer A, Lennemann NJ, Ouyang Y, et al. Type III interferons produced by human placental trophoblasts confer protection against Zika virus infection[J]. Cell Host Microbe, 2016, 19(5): 705-712. DOI:10.1016/j.chom.2016.03.008
[16] Mahlakoiv T, Hernandez P, Gronke K, et al. Leukocyte-derived IFN-alpha/beta and epithelial IFN-lambda constitute a compartmentalized mucosal defense system that restricts enteric virus infections[J]. PLoS Pathog, 2015, 11(4): e1004782. DOI:10.1371/journal.ppat.1004782
[17] Mordstein M, Neugebauer E, Ditt V, et al. Lambda interferon renders epithelial cells of the respiratory and gastrointestinal tracts resistant to viral infections[J]. J Virol, 2010, 84(11): 5670-5677. DOI:10.1128/JVI.00272-10
[18] Pott J, Mahlakoiv T, Mordstein M, et al. IFN-lambda determines the intestinal epithelial antiviral host defense[J]. Proc Natl Acad Sci U S A, 2011, 108(19): 7944-7949. DOI:10.1073/pnas.1100552108
[19] Lazear HM, Daniels BP, Pinto AK, et al. Interferon-lambda restricts West Nile virus neuroinvasion by tightening the blood-brain barrier[J]. Sci Transl Med, 2015, 7(284): 284ra59. DOI:10.1126/scitranslmed.aaa4304
[20] Jurado KA, Simoni MK, Tang Z, et al. Zika virus productively infects primary human placenta-specific macrophages[J]. JCI Insight, 2016, 1(13): e88461. DOI:10.1172/jci.insight.88461
[21] Simoni MK, Jurado KA, Abrahams VM, et al. Zika virus infection of Hofbauer cells[J]. Am J Reprod Immunol, 2017, 77(2): e12613. DOI:10.1111/aji.12613
[22] Ritter JM, Martines RB,Zaki S R. Zika virus: pathology from the pandemic[J]. Arch Pathol Lab Med, 2017, 141(1): 49-59. DOI:10.5858/arpa.2016-0397-SA
[23] Iwasaki A,Pillai PS. Innate immunity to influenza virus infection[J]. Nat Rev Immunol, 2014, 14(5): 315-328. DOI:10.1038/nri3665nri3665
[24] Andrade D, Kim M, Blanco LP, et al. Interferon-alpha and angiogenic dysregulation in pregnant lupus patients who develop preeclampsia[J]. Arthritis Rheumatol, 2015, 67(4): 977-987. DOI:10.1002/art.39029
[25] Lazear HM, Nice TJ,Diamond MS. Interferon-lambda: immune functions at barrier surfaces and beyond[J]. Immunity, 2015, 43(1): 15-28. DOI:10.1016/j.immuni.2015.07.001
[26] Rossi SL, Tesh RB, Azar SR, et al. Characterization of a novel murine model to study Zika virus[J]. Am J Trop Med Hyg, 2016, 94(6): 1362-1369. DOI:10.4269/ajtmh.16-0111
[27] Cugola FR, Fernandes IR, Russo FB, et al. The Brazilian Zika virus strain causes birth defects in experimental models[J]. Nature, 2016, 534(7606): 267-271. DOI:10.1038/nature18296
[28] Dowall SD, Graham VA, Rayner E, et al. A susceptible mouse model for Zika virus infection[J]. PLoS Negl Trop Dis, 2016, 10(5): e0004658. DOI:10.1371/journal.pntd.0004658
[29] Jagger BW, Miner JJ, Cao B, et al. Gestational stage and IFN-lambda signaling regulate ZIKV infection in Utero[J]. Cell Host Microbe, 2017, 22(3): 366-376.e3. DOI:10.1016/j.chom.2017.08.012
[30] Coyne CB,Lazear HM. Zika virus - reigniting the TORCH[J]. Nat Rev Microbiol, 2016, 14(11): 707-715. DOI:10.1038/nrmicro.2016.125
[31] Honein MA, Dawson AL, Petersen EE, et al. Birth defects among fetuses and infants of US women with evidence of possible Zika virus infection during pregnancy[J]. JAMA, 2017, 317(1): 59-68. DOI:10.1001/jama.2016.19006
[32] Kleber de Oliveira W, Cortez-Escalante J, De Oliveira WT, et al. Increase in reported prevalence of microcephaly in infants born to women living in areas with confirmed Zika virus transmission during the first trimester of pregnancy - Brazil, 2015[J]. MMWR, 2016, 65(9): 242-247. DOI:10.15585/mmwr.mm6509e2
[33] Arora N, Sadovsky Y, Dermody TS, et al. Microbial vertical transmission during human pregnancy[J]. Cell Host Microbe, 2017, 21(5): 561-567. DOI:10.1016/j.chom.2017.04.007
[34] Anson-Cartwright L, Dawson K, Holmyard D, et al. The glial cells missing-1 protein is essential for branching morphogenesis in the chorioallantoic placenta[J]. Nat Genet, 2000, 25(3): 311-314. DOI:10.1038/77076
[35] Tscherning-Casper C, Papadogiannakis N, Anvret M, et al. The trophoblastic epithelial barrier is not infected in full-term placentae of human immunodeficiency virus-seropositive mothers undergoing antiretroviral therapy[J]. J Virol, 1999, 73(11): 9673-9678.
[2] Rubin EJ, Greene M F,Baden LR. Zika virus and microcephaly[J]. N Engl J Med, 2016, 374(10): 984-985. DOI:10.1056/NEJMe1601862
[3] Schuler-Faccini L, Ribeiro EM, Feitosa IM, et al. Possible association between Zika virus infection and microcephaly - Brazil, 2015[J]. MMWR, 2016, 65(3):59-62. DOI: 10.15585/mmwr.mm6503e2
[4] Oliveira Melo AS, Malinger G, Ximenes R, et al. Zika virus intrauterine infection causes fetal brain abnormality and microcephaly: tip of the iceberg[J]. Ultrasound Obstet Gynecol, 2016, 47(1): 6-7. DOI:10.1002/uog.15831
[5] Martines RB, Bhatnagar J, Keating MK, et al. Notes from the field: evidence of Zika virus infection in Brain and placental tissues from two congenitally infected newborns and two fetal losses-Brazil, 2015[J]. MMWR, 2016, 65(6):159-160. DOI:10.15585/mmwr.mm6506e1
[6] Xiang B, Gao P, Kang Y, et al. Importation of Zika virus in China: a significant risk in southern China[J]. J Infect, 2017, 74(3): 328-330. DOI:10.1016/j.jinf.2017.01.004
[7] Wells MF, Salick MR, Wiskow O, et al. Genetic ablation of AXL does not protect human neural progenitor cells and cerebral organoids from Zika virus infection[J]. Cell Stem Cell, 2016, 19(6): 703-708. DOI:10.1016/j.stem.2016.11.011
[8] Hamel R, Dejarnac O, Wichit S, et al. Biology of Zika virus infection in human skin cells[J]. J Virol, 2015, 89(17): 8880-8896. DOI:10.1128/JVI.00354-15
[9] Kotenko SV, Gallagher G, Baurin VV, et al. IFN-lambdas mediate antiviral protection through a distinct class II cytokine receptor complex[J]. Nat Immunol, 2003, 4(1): 69-77. DOI:10.1038/ni875
[10] Hamming OJ, Terczynska-Dyla E, Vieyres G, et al. Interferon lambda 4 signals via the IFNlambda receptor to regulate antiviral activity against HCV and coronaviruses[J]. EMBO J, 2013, 32(23): 3055-3065. DOI:10.1038/emboj.2013.232
[11] Hernandez PP, Mahlakoiv T, Yang I, et al. Interferon-lambda and interleukin 22 act synergistically for the induction of interferon-stimulated genes and control of rotavirus infection[J]. Nat Immunol, 2015, 16(7): 698-707. DOI:10.1038/ni.3180
[12] Kane M, Yadav SS, Bitzegeio J, et al. MX2 is an interferon-induced inhibitor of HIV-1 infection[J]. Nature, 2013, 502(7472): 563-566. DOI:10.1038/nature12653
[13] Liu SY, Aliyari R, Chikere K, et al. Interferon-inducible cholesterol-25-hydroxylase broadly inhibits viralentry by production of 25-hydroxycholesterol[J]. Immunity, 2013, 38(1): 92-105. DOI:10.1016/j.immuni.2012.11.005
[14] Chen J, Liang Y, Yi P, et al. Outcomes of congenital Zika disease depend on timing of infection and maternal-fetal interferon action[J]. Cell Rep, 2017, 21(6):1588-1599. DOI:10.1016/j.celrep.2017.10.059
[15] Bayer A, Lennemann NJ, Ouyang Y, et al. Type III interferons produced by human placental trophoblasts confer protection against Zika virus infection[J]. Cell Host Microbe, 2016, 19(5): 705-712. DOI:10.1016/j.chom.2016.03.008
[16] Mahlakoiv T, Hernandez P, Gronke K, et al. Leukocyte-derived IFN-alpha/beta and epithelial IFN-lambda constitute a compartmentalized mucosal defense system that restricts enteric virus infections[J]. PLoS Pathog, 2015, 11(4): e1004782. DOI:10.1371/journal.ppat.1004782
[17] Mordstein M, Neugebauer E, Ditt V, et al. Lambda interferon renders epithelial cells of the respiratory and gastrointestinal tracts resistant to viral infections[J]. J Virol, 2010, 84(11): 5670-5677. DOI:10.1128/JVI.00272-10
[18] Pott J, Mahlakoiv T, Mordstein M, et al. IFN-lambda determines the intestinal epithelial antiviral host defense[J]. Proc Natl Acad Sci U S A, 2011, 108(19): 7944-7949. DOI:10.1073/pnas.1100552108
[19] Lazear HM, Daniels BP, Pinto AK, et al. Interferon-lambda restricts West Nile virus neuroinvasion by tightening the blood-brain barrier[J]. Sci Transl Med, 2015, 7(284): 284ra59. DOI:10.1126/scitranslmed.aaa4304
[20] Jurado KA, Simoni MK, Tang Z, et al. Zika virus productively infects primary human placenta-specific macrophages[J]. JCI Insight, 2016, 1(13): e88461. DOI:10.1172/jci.insight.88461
[21] Simoni MK, Jurado KA, Abrahams VM, et al. Zika virus infection of Hofbauer cells[J]. Am J Reprod Immunol, 2017, 77(2): e12613. DOI:10.1111/aji.12613
[22] Ritter JM, Martines RB,Zaki S R. Zika virus: pathology from the pandemic[J]. Arch Pathol Lab Med, 2017, 141(1): 49-59. DOI:10.5858/arpa.2016-0397-SA
[23] Iwasaki A,Pillai PS. Innate immunity to influenza virus infection[J]. Nat Rev Immunol, 2014, 14(5): 315-328. DOI:10.1038/nri3665nri3665
[24] Andrade D, Kim M, Blanco LP, et al. Interferon-alpha and angiogenic dysregulation in pregnant lupus patients who develop preeclampsia[J]. Arthritis Rheumatol, 2015, 67(4): 977-987. DOI:10.1002/art.39029
[25] Lazear HM, Nice TJ,Diamond MS. Interferon-lambda: immune functions at barrier surfaces and beyond[J]. Immunity, 2015, 43(1): 15-28. DOI:10.1016/j.immuni.2015.07.001
[26] Rossi SL, Tesh RB, Azar SR, et al. Characterization of a novel murine model to study Zika virus[J]. Am J Trop Med Hyg, 2016, 94(6): 1362-1369. DOI:10.4269/ajtmh.16-0111
[27] Cugola FR, Fernandes IR, Russo FB, et al. The Brazilian Zika virus strain causes birth defects in experimental models[J]. Nature, 2016, 534(7606): 267-271. DOI:10.1038/nature18296
[28] Dowall SD, Graham VA, Rayner E, et al. A susceptible mouse model for Zika virus infection[J]. PLoS Negl Trop Dis, 2016, 10(5): e0004658. DOI:10.1371/journal.pntd.0004658
[29] Jagger BW, Miner JJ, Cao B, et al. Gestational stage and IFN-lambda signaling regulate ZIKV infection in Utero[J]. Cell Host Microbe, 2017, 22(3): 366-376.e3. DOI:10.1016/j.chom.2017.08.012
[30] Coyne CB,Lazear HM. Zika virus - reigniting the TORCH[J]. Nat Rev Microbiol, 2016, 14(11): 707-715. DOI:10.1038/nrmicro.2016.125
[31] Honein MA, Dawson AL, Petersen EE, et al. Birth defects among fetuses and infants of US women with evidence of possible Zika virus infection during pregnancy[J]. JAMA, 2017, 317(1): 59-68. DOI:10.1001/jama.2016.19006
[32] Kleber de Oliveira W, Cortez-Escalante J, De Oliveira WT, et al. Increase in reported prevalence of microcephaly in infants born to women living in areas with confirmed Zika virus transmission during the first trimester of pregnancy - Brazil, 2015[J]. MMWR, 2016, 65(9): 242-247. DOI:10.15585/mmwr.mm6509e2
[33] Arora N, Sadovsky Y, Dermody TS, et al. Microbial vertical transmission during human pregnancy[J]. Cell Host Microbe, 2017, 21(5): 561-567. DOI:10.1016/j.chom.2017.04.007
[34] Anson-Cartwright L, Dawson K, Holmyard D, et al. The glial cells missing-1 protein is essential for branching morphogenesis in the chorioallantoic placenta[J]. Nat Genet, 2000, 25(3): 311-314. DOI:10.1038/77076
[35] Tscherning-Casper C, Papadogiannakis N, Anvret M, et al. The trophoblastic epithelial barrier is not infected in full-term placentae of human immunodeficiency virus-seropositive mothers undergoing antiretroviral therapy[J]. J Virol, 1999, 73(11): 9673-9678.