黄体酮个体化治疗复发性流产的效果评价
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摘要
目的探讨黄体酮个体化治疗复发性流产的效果。方法 90例复发性流产患者,根据治疗方式不同分为对照组(43例)和观察组(47例)。对照组患者给予常规治疗,观察组患者给予黄体酮个体化治疗。观察对比两组患者的黄体酮注射时间、总用药量、流产、早产及围生儿不良结局发生情况。结果观察组的黄体酮注射时间(36.71±6.22)d短于对照组的(43.98±3.83)d,总用药量(1455.82±203.44)mg少于对照组的(1829.68±203.37)mg,差异具有统计学意义(P<0.05)。观察组的流产、早产及围生儿不良结局发生率分别为2.13%、4.26%、0,均明显低于对照组的13.95%、18.60%、13.95%,差异具有统计学意义(P<0.05)。结论采取黄体酮个体化治疗复发性流产,能有效降低患者流产、早产及围生儿不良结局发生率,值得临床推广应用。
Objective To discuss the effect of individualized progesterone therapy for the treatment of recurrent abortion. Methods A total of 90 patients with recurrent abortion were divided by different treatment methods into control group(43 cases) and observation group(47 cases). The control group received conventional therapy, and the observation group received individualized progesterone therapy. Observation and comparison were made on progesterone injection time, total dosage, occurrence of abortion, premature delivery and adverse perinatal outcomes between the two groups. Results The observation group had shorter progesterone injection time as(36.71±6.22) d than(43.98±3.83) d in the control group, and less total dosage as(1455.82±203.44) mg than(1829.68±203.37) mg in the control group. Their difference was statistically significant(P<0.05). The observation group had obviously lower incidence of abortion, premature delivery and adverse perinatal outcomes respectively as 2.13%, 4.26% and 0 than 13.95%, 18.60% and 13.95% in the control group, and their difference was statistically significant(P<0.05). Conclusion Individualized progesterone therapy for recurrent abortion can effectively lower the incidence of abortion, premature delivery and adverse perinatal outcomes, and it is worthy of clinical application.
Objective To discuss the effect of individualized progesterone therapy for the treatment of recurrent abortion. Methods A total of 90 patients with recurrent abortion were divided by different treatment methods into control group(43 cases) and observation group(47 cases). The control group received conventional therapy, and the observation group received individualized progesterone therapy. Observation and comparison were made on progesterone injection time, total dosage, occurrence of abortion, premature delivery and adverse perinatal outcomes between the two groups. Results The observation group had shorter progesterone injection time as(36.71±6.22) d than(43.98±3.83) d in the control group, and less total dosage as(1455.82±203.44) mg than(1829.68±203.37) mg in the control group. Their difference was statistically significant(P<0.05). The observation group had obviously lower incidence of abortion, premature delivery and adverse perinatal outcomes respectively as 2.13%, 4.26% and 0 than 13.95%, 18.60% and 13.95% in the control group, and their difference was statistically significant(P<0.05). Conclusion Individualized progesterone therapy for recurrent abortion can effectively lower the incidence of abortion, premature delivery and adverse perinatal outcomes, and it is worthy of clinical application.
引文
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[8]李维宏,牟晓玲.黄体酮保胎治疗对不明原因复发性流产患者外周血辅助性T淋巴细胞17/调节性T淋巴细胞免疫失衡的影响研究.中国全科医学, 2015, 18(36):4444-4449.
[9]王荣.黄体酮阴道凝胶联合地屈孕酮治疗不明原因早期复发性流产疗效观察.中国妇幼保健, 2016, 31(12):2518-2520.
[10]袁秀红,张媛媛.地屈孕酮联合黄体酮治疗复发性流产临床观察.延安大学学报(医学科学版), 2015, 13(3):55-57.
[11]高原,沈宇清,郑亮玉.淋巴细胞主动免疫联合黄体酮治疗原因不明复发性流产的疗效分析.中国当代医药, 2016, 23(10):114-116.
[2]尚艳梅.复发性流产应用黄体酮个体化治疗的临床观察.中国实用医药, 2014, 9(24):165-166.
[3]旷晓平.黄体酮个体化治疗复发性流产的效果观察.中国实用医药, 2014, 9(24):178-179.
[4]郑海珍,陈彩飞.宫腔镜手术联合黄体酮冶疗子宫内膜息肉的临床效果分析.现代实用医学, 2014, 26(7):849-851.
[5]杨晓静,王伟强.黄体酮个体化治疗复发性流产的疗效及安全性.临床医学研究与实践, 2017, 2(33):149-150.
[6]张秋月,邹健军.不明原因复发性流产使用黄体酮治疗的可行性研究.齐齐哈尔医学院学报, 2016, 37(29):33-34.
[7]曹井贺,杨爱军,位玲霞.黄体酮联合主动免疫治疗对复发流产相关因子的研究.中国妇幼健康研究, 2018, 29(4):491-494.
[8]李维宏,牟晓玲.黄体酮保胎治疗对不明原因复发性流产患者外周血辅助性T淋巴细胞17/调节性T淋巴细胞免疫失衡的影响研究.中国全科医学, 2015, 18(36):4444-4449.
[9]王荣.黄体酮阴道凝胶联合地屈孕酮治疗不明原因早期复发性流产疗效观察.中国妇幼保健, 2016, 31(12):2518-2520.
[10]袁秀红,张媛媛.地屈孕酮联合黄体酮治疗复发性流产临床观察.延安大学学报(医学科学版), 2015, 13(3):55-57.
[11]高原,沈宇清,郑亮玉.淋巴细胞主动免疫联合黄体酮治疗原因不明复发性流产的疗效分析.中国当代医药, 2016, 23(10):114-116.