代谢性谷氨酸受体5参与吗啡耐受及其机制
摘要
<正>长期使用吗啡将造成吗啡耐受,表现为吗啡镇痛效应减弱,需加大药物剂量才能达到相同的效果。吗啡耐受现象大大限制了阿片类药物在临床的应用,也成为疼痛治疗中的难题。其发生机制至今仍不明确。谷氨酸是中枢神经系统一种主要的兴奋性神经递质,对脑功能整合和神经元细胞生长起重要作用。谷氨酸与谷氨酸受体结合后
引文
[1]PIN J P,DUVOISIN R.The metabotropic glutamate receptors:structure and functions[J].Neuropharmacology,1995,34(1):1-26.
[2]刘金变,江伟.Ⅰ组代谢型谷氨酸受体拮抗剂对吗啡耐受大鼠热痛阈的影响[J].上海医学,2010,33(4):316-318.
[3]TAKAHASHI T,FORSYTHE I D,TSUJIMOTO T,et al.Presynaptic calcium current modulation by a metabotropic glutamate receptor[J].Science,1996,274(5287):594-597.
[4]JOLY C,GOMEZA J,BRABET I,et al.Molecular,functional,and pharmacological characterization of the metabotropic glutamate receptor type 5splice variants:comparison with mGluR1[J].J Neurosci,1995,15(5Pt 2):3970-3981.
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[6]SMITH F L,SMITH P A,DEWEY W L,et al.Effects of mGlu1and mGlu5 metabotropic glutamate antagonists to reverse morphine tolerance in mice[J].Eur J Pharmacol,2004,492(2-3):137-142.
[7]XU T,CHEN M,ZHOU Q,et al.Antisense oligonucleotide knockdown of mGlu5receptor attenuates the antinociceptive tolerance and up-regulated expression of spinal protein kinase C associated with chronic morphine treatment[J].Eur J Pharmacol,2012,683(1-3):78-85.
[8]BORDI F,UGOLINI A.Group I metabotropic glutamate receptors:implications for brain diseases[J].Prog Neurobiol,1999,59(1):55-79.
[9]MAO J,PRICE D D,MAYER D J.Mechanisms of hyperalgesia and morphine tolerance:a current view of their possible interactions[J].Pain,1995,62(3):259-274.
[10]WELCH S P,BASS P P.Modulation of free intracellular calcium levels[(Ca++)i]in brain and spinal cord of morphine-tolerant rats and mice[J].Pharmacol Biochem Behav,1995,51(1):57-63.
[11]MESTEK A,HURLEY J H,BYE L S,et al.The human mu opioid receptor:modulation of functional desensitization by calcium/calmodulin-dependent protein kinase and protein kinase C[J].J Neurosci,1995,15(3Pt 2):2396-2406.
[12]WANG Z,ARDEN J,SADE W.Basal phosphorylation of mu opioid receptor is agonist modulated and Ca2+-dependent[J].FEBS Lett,1996,387(1):53-57.
[13]MAYER D J,MAO J,PRICE D D.The development of morphine tolerance and dependence is associated with translocation of protein kinase C[J].Pain,1995,61(3):365-374.
[14]KOZELA E,PILC A,POPIK P.Inhibitory effects of MPEP,an mGluR5 antagonist,and memantine,an Nmethyl-D-aspartate receptor antagonist,on morphine antinociceptive tolerance in mice[J].Psychopharmacology(Berl),2003,165(3):245-251.
[15]CHEN Y,GEIS C,SOMMER C.Activation of TRPV1contributes to morphine tolerance:involvement of the mitogen-activated protein kinase signaling pathway[J].J Neurosci,2008,28(22):5836-5845.
[16]SCHULZ R,EISINGER D A,WEHMEYER A.Opioid control of MAP kinase cascade[J].Eur J Pharmacol,2004,500(1-3):487-497.
[17]CHEN Y,SOMMER C.The role of mitogen-activated protein kinase(MAPK)in morphine tolerance and dependence[J].Mol Neurobiol,2009,40(2):101-107.
[18]WANG J Q,FIBUCH E E,MAO L.Regulation of mitogen-activated protein kinases by glutamate receptors[J].J Neurochem,2007,100(1):1-11.
[19]WANG Q,CHANG L,ROWAN M J,et al.Developmental dependence,the role of the kinases p38 MAPK and PKC,and the involvement of tumor necrosis factor-R1in the induction of mGlu-5 LTD in the dentate gyrus[J].Neuroscience,2007,144(1):110-118.
[20]XU T,JIANG W,DU D,et al.Inhibition of MPEP on the development of morphine antinociceptive tolerance and the biosynthesis of neuronal nitric oxide synthase in rat spinal cord[J].Neurosci Lett,2008,436(2):214-218.
[21]SUZUKI M,NARITA M,NARITA M,et al.Chronic morphine treatment increases the expression of the neural cell adhesion molecule in the dorsal horn of the mouse spinal cord[J].Neurosci Lett,2006,399(3):202-205.
[22]MARTIN G,PRZEWLOCKI R,SIGGINS G R.Chronic morphine treatment selectively augments metabotropic glutamate receptor-induced inhibition of N-methyl-D-aspartate receptormediated neurotransmission in nucleus accumbens[J].J Pharmacol Exp Ther,1999,288(1):30-35.
[23]MAO J.NMDA and opioid receptors:their interactions in antinociception,tolerance and neuroplasticity[J].Brain Res Brain Res Rev,1999,30(3):289-304.
[24]FUNDYTUS M E,CODERRE T J.Effect of activity at metabotropic,as well as ionotropic(NMDA),glutamate receptors on morphine dependence[J].Br J Pharmacol,1994,113(4):1215-1220.
[25]DOHERTY A J,PALMER M J,HENLEY J M,et al.(RS)-2-chloro-5-hydroxyphenylglycine(CHPG)activates mGlu5,but no mGlu1,receptors expressed in CHO cells and potentiates NMDA responses in the hippocampus[J].Neuropharmacology,1997,36(2):265-267.
[26]PISANI A,GUBELLINI P,BONSI P,et al.Metabotropic glutamate receptor 5mediates the potentiation of N-methylD-aspartate responses in medium spiny striatal neurons[J].Neuroscience,2001,106(3):579-587.
[27]CHEN L,HUANG L Y.Protein kinase C reduces Mg2+block of NMDA-receptor channels as a mechanism of modulation[J].Nature,1992,356(6369):521-523.
[28]THOMAS L S,JANE D E,HARRIS J R,et al.Metabotropic glutamate autoreceptors of the mGlu(5)subtype positively modulate neuronal glutamate release in the rat forebrain in vitro[J].Neuropharmacology,2000,39(9):1554-1566.
[29]THOMAS L S,JANE D E,GASPARINI F,et al.Glutamate release inhibiting properties of the novel mGlu(5)receptor antagonist 2-methyl-6-(phenylethynyl)-pyridine(MPEP):complementary in vitro and in vivo evidence[J].Neuropharmacology,2001,41(4):523-527.
[30]SCHOEPP D D.Unveiling the functions of presynaptic metabotropic glutamate receptors in the central nervous system[J].J Pharmacol Exp Ther,2001,299(1):12-20.
[31]PICKER M J,DAUGHERTY D,HENRY F E,et al.Metabotropic glutamate antagonists alone and in combination with morphine:comparison across two models of acute pain and a model of persistent,inflammatory pain[J].Behav Pharmacol,2011,22(8):785-793.
[2]刘金变,江伟.Ⅰ组代谢型谷氨酸受体拮抗剂对吗啡耐受大鼠热痛阈的影响[J].上海医学,2010,33(4):316-318.
[3]TAKAHASHI T,FORSYTHE I D,TSUJIMOTO T,et al.Presynaptic calcium current modulation by a metabotropic glutamate receptor[J].Science,1996,274(5287):594-597.
[4]JOLY C,GOMEZA J,BRABET I,et al.Molecular,functional,and pharmacological characterization of the metabotropic glutamate receptor type 5splice variants:comparison with mGluR1[J].J Neurosci,1995,15(5Pt 2):3970-3981.
[5]LSCHER W.Pharmacology of glutamate receptor antagonists in the kindling model of epilepsy[J].Prog Neurobiol,1998,54(6):721-741.
[6]SMITH F L,SMITH P A,DEWEY W L,et al.Effects of mGlu1and mGlu5 metabotropic glutamate antagonists to reverse morphine tolerance in mice[J].Eur J Pharmacol,2004,492(2-3):137-142.
[7]XU T,CHEN M,ZHOU Q,et al.Antisense oligonucleotide knockdown of mGlu5receptor attenuates the antinociceptive tolerance and up-regulated expression of spinal protein kinase C associated with chronic morphine treatment[J].Eur J Pharmacol,2012,683(1-3):78-85.
[8]BORDI F,UGOLINI A.Group I metabotropic glutamate receptors:implications for brain diseases[J].Prog Neurobiol,1999,59(1):55-79.
[9]MAO J,PRICE D D,MAYER D J.Mechanisms of hyperalgesia and morphine tolerance:a current view of their possible interactions[J].Pain,1995,62(3):259-274.
[10]WELCH S P,BASS P P.Modulation of free intracellular calcium levels[(Ca++)i]in brain and spinal cord of morphine-tolerant rats and mice[J].Pharmacol Biochem Behav,1995,51(1):57-63.
[11]MESTEK A,HURLEY J H,BYE L S,et al.The human mu opioid receptor:modulation of functional desensitization by calcium/calmodulin-dependent protein kinase and protein kinase C[J].J Neurosci,1995,15(3Pt 2):2396-2406.
[12]WANG Z,ARDEN J,SADE W.Basal phosphorylation of mu opioid receptor is agonist modulated and Ca2+-dependent[J].FEBS Lett,1996,387(1):53-57.
[13]MAYER D J,MAO J,PRICE D D.The development of morphine tolerance and dependence is associated with translocation of protein kinase C[J].Pain,1995,61(3):365-374.
[14]KOZELA E,PILC A,POPIK P.Inhibitory effects of MPEP,an mGluR5 antagonist,and memantine,an Nmethyl-D-aspartate receptor antagonist,on morphine antinociceptive tolerance in mice[J].Psychopharmacology(Berl),2003,165(3):245-251.
[15]CHEN Y,GEIS C,SOMMER C.Activation of TRPV1contributes to morphine tolerance:involvement of the mitogen-activated protein kinase signaling pathway[J].J Neurosci,2008,28(22):5836-5845.
[16]SCHULZ R,EISINGER D A,WEHMEYER A.Opioid control of MAP kinase cascade[J].Eur J Pharmacol,2004,500(1-3):487-497.
[17]CHEN Y,SOMMER C.The role of mitogen-activated protein kinase(MAPK)in morphine tolerance and dependence[J].Mol Neurobiol,2009,40(2):101-107.
[18]WANG J Q,FIBUCH E E,MAO L.Regulation of mitogen-activated protein kinases by glutamate receptors[J].J Neurochem,2007,100(1):1-11.
[19]WANG Q,CHANG L,ROWAN M J,et al.Developmental dependence,the role of the kinases p38 MAPK and PKC,and the involvement of tumor necrosis factor-R1in the induction of mGlu-5 LTD in the dentate gyrus[J].Neuroscience,2007,144(1):110-118.
[20]XU T,JIANG W,DU D,et al.Inhibition of MPEP on the development of morphine antinociceptive tolerance and the biosynthesis of neuronal nitric oxide synthase in rat spinal cord[J].Neurosci Lett,2008,436(2):214-218.
[21]SUZUKI M,NARITA M,NARITA M,et al.Chronic morphine treatment increases the expression of the neural cell adhesion molecule in the dorsal horn of the mouse spinal cord[J].Neurosci Lett,2006,399(3):202-205.
[22]MARTIN G,PRZEWLOCKI R,SIGGINS G R.Chronic morphine treatment selectively augments metabotropic glutamate receptor-induced inhibition of N-methyl-D-aspartate receptormediated neurotransmission in nucleus accumbens[J].J Pharmacol Exp Ther,1999,288(1):30-35.
[23]MAO J.NMDA and opioid receptors:their interactions in antinociception,tolerance and neuroplasticity[J].Brain Res Brain Res Rev,1999,30(3):289-304.
[24]FUNDYTUS M E,CODERRE T J.Effect of activity at metabotropic,as well as ionotropic(NMDA),glutamate receptors on morphine dependence[J].Br J Pharmacol,1994,113(4):1215-1220.
[25]DOHERTY A J,PALMER M J,HENLEY J M,et al.(RS)-2-chloro-5-hydroxyphenylglycine(CHPG)activates mGlu5,but no mGlu1,receptors expressed in CHO cells and potentiates NMDA responses in the hippocampus[J].Neuropharmacology,1997,36(2):265-267.
[26]PISANI A,GUBELLINI P,BONSI P,et al.Metabotropic glutamate receptor 5mediates the potentiation of N-methylD-aspartate responses in medium spiny striatal neurons[J].Neuroscience,2001,106(3):579-587.
[27]CHEN L,HUANG L Y.Protein kinase C reduces Mg2+block of NMDA-receptor channels as a mechanism of modulation[J].Nature,1992,356(6369):521-523.
[28]THOMAS L S,JANE D E,HARRIS J R,et al.Metabotropic glutamate autoreceptors of the mGlu(5)subtype positively modulate neuronal glutamate release in the rat forebrain in vitro[J].Neuropharmacology,2000,39(9):1554-1566.
[29]THOMAS L S,JANE D E,GASPARINI F,et al.Glutamate release inhibiting properties of the novel mGlu(5)receptor antagonist 2-methyl-6-(phenylethynyl)-pyridine(MPEP):complementary in vitro and in vivo evidence[J].Neuropharmacology,2001,41(4):523-527.
[30]SCHOEPP D D.Unveiling the functions of presynaptic metabotropic glutamate receptors in the central nervous system[J].J Pharmacol Exp Ther,2001,299(1):12-20.
[31]PICKER M J,DAUGHERTY D,HENRY F E,et al.Metabotropic glutamate antagonists alone and in combination with morphine:comparison across two models of acute pain and a model of persistent,inflammatory pain[J].Behav Pharmacol,2011,22(8):785-793.