循环外泌体在酮病奶牛肝脏脂代谢紊乱中的生理作用
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摘要
奶牛酮病是由能量负平衡引起的,是围产期常见代谢紊乱性疾病。外泌体是含有膜蛋白、封闭胞质蛋白和RNA的磷脂双分子层的膜泡,可以传递信息并调节机体细胞的生理状态。本文就循环外泌体对奶牛肝脏脂代谢的影响、对腺苷酸活化蛋白激酶α/沉默信息调节因子1(AMPKα/SIRT1)通路的调节作用,以及作为酮病奶牛肝脏脂代谢紊乱诊断标志物的研究现状进行综述,有助于探究奶牛循环外泌体对酮病奶牛肝脏脂代谢紊乱的修复效果和作用机制,为寻找合适的酮病靶向治疗药物提供理论和实践依据。
Dairy cows ketosis is caused by negative energy balance and is a common metabolic disorder in perinatal period. The exosomes are a class of vesicles containing membrane proteins,blocked cytoplasmic proteins and RNA,which can transmit information to regulate the physiological state of the body cells. This article reviewed that circulating exosomes exert an influence on liver lipid metabolism in dairy cows,regulate adenosine5'-monophosphate-activated protein kinase α/silencing signal regulator 1( AMPKα-SIRT1) pathway,and act as diagnostic markers for hepatic lipid metabolism disorders in ketosis cows. To sum up,this reviewof the current research status is helpful to explore the repairing effect and mechanism of circulating exosomes on hepatic lipid metabolism disorder in ketosis cows,and provides theoretical and practical basis for finding suitable targeted drugs for ketosis.[Chinese Journal of Animal Nutrition,2019,31(7):3004-3008]
Dairy cows ketosis is caused by negative energy balance and is a common metabolic disorder in perinatal period. The exosomes are a class of vesicles containing membrane proteins,blocked cytoplasmic proteins and RNA,which can transmit information to regulate the physiological state of the body cells. This article reviewed that circulating exosomes exert an influence on liver lipid metabolism in dairy cows,regulate adenosine5'-monophosphate-activated protein kinase α/silencing signal regulator 1( AMPKα-SIRT1) pathway,and act as diagnostic markers for hepatic lipid metabolism disorders in ketosis cows. To sum up,this reviewof the current research status is helpful to explore the repairing effect and mechanism of circulating exosomes on hepatic lipid metabolism disorder in ketosis cows,and provides theoretical and practical basis for finding suitable targeted drugs for ketosis.[Chinese Journal of Animal Nutrition,2019,31(7):3004-3008]
引文
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[12] LEWIS A P,JOPLING C L.Regulation and biological function of the liver-specific miR-122[J].Biochemical Society Transactions,2010,38(6):1553-1557.
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[14] ZHANG Y,YU M,TIAN W D. Physiological and pathological impact of exosomes of adipose tissue[J].Cell Proliferation,2016,49(1):3-13.
[15] HARDIE D G.The AMP-activated protein kinase cascade:the key sensor of cellular energy status[J]. Endocrinology,2003,144(12):5179-5183.
[16] VIOLLET B,FORETZ M,GUIGAS B,et al. Activation of AMP-activated protein kinase in the liver:a newstrategy for the management of metabolic hepatic disorders[J]. The Journal of Physiology,2006,574(1):41-53.
[17] LONG Y C,ZIERATH J R.AMP-activated protein kinase signaling in metabolic regulation[J]. The Journal of Clinical Investigation,2006,116(7):1776-1783.
[18] CANTC,GERHART-HINES Z,FEIGE J N,et al.AMPK regulates energy expenditure by modulating NAD+metabolism and SIRT1 activity[J]. Nature,2009,458(7241):1056-1060.
[19] LIU L,JIN X,HU C F,et al.Exosomes derived from mesenchymal stem cells rescue myocardial ischaemia/reperfusion injury by inducing cardiomyocyte autophagy via AMPK and Akt pathways[J]. Cellular Physiology and Biochemistry,2017,43(1):52-68.
[20] SARAKUL O,VATTANAVIBOON P,TANAKA Y,et al.Enhanced erythroid cell differentiation in hypoxic condition is in part contributed by miR-210[J]. Blood Cells,Molecules,and Diseases,2013,51(2):98-103.
[21]明鹏飞,黄莹莹,董妍丽,等. LKB1-AMPKα-SIRT1信号通路在奶牛脂肪组织脂代谢中的调控作用[J].生物技术通报,2019,35(2):176-181.
[22] CROOKENDEN MA,WALKER C G,PEIRIS H,et al. Short communication:proteins from circulating exosomes represent metabolic state in transition dairy cows[J]. Journal of Dairy Science,2016,99(9):7661-7668.
[23] MITCHELL MD,SCHOLZ-ROMERO K,REED S,et al. Plasma exosome profiles from dairy cows with divergent fertility phenotypes[J].Journal of Dairy Science,2016,99(9):7590-7601.
[24] KORNEK M,SCHUPPAN D.Microparticles:modulators and biomarkers of liver disease[J]. Journal of Hepatology,2012,57(5):1144-1146.
[25] LEMOINNE S,THABUT D,HOUSSET C,et al.The emerging roles of microvesicles in liver diseases[J].Nature Reviews Gastroenterology&Hepatology,2014,11(6):350-361.
[26] BALA S,PETRASEK J,MUNDKUR S,et al. Circulating microRNAs in exosomes indicate hepatocyte injury and inflammation in alcoholic,drug-induced,and inflammatory liver diseases[J]. Hepatology,2012,56(5):1946-1957.
[27] MOMEN-HERAVI F,BALA S,KODYS K,et al.Exosomes derived from alcohol-treated hepatocytes horizontally transfer liver specific miRNA-122 and sensitize monocytes to LPS[J].Scientific Reports,2015,5:9991.
[28] POVERO D,EGUCHI A,LI H Y,et al. Circulating extracellular vesicles with specific proteome and liver microRNAs are potential biomarkers for liver injury in experimental fatty liver disease[J].PLoS One,2014,9(12):e113651.
[29] ZHAO K,LIANG G X,SUN X,et al. Comparative miRNAome analysis revealed different miRNA expression profiles in bovine sera and exosomes[J].BMC Genomics,2016,17(1):630.
[30] LIU Y N,LOU G H,LI A C,et al.AMSC-derived exosomes alleviate lipopolysaccharide/D-galactosamineinduced acute liver failure by miR-17-mediated reduction of TXNIP/NLRP3 inflammasome activation in macrophages[J].EBioMedicine,2018,36:140-150.
[2] MARQUS-GARCA F,ISIDORO-GARCA M. Protocols for exosome isolation and RNA profiling[J].Methods in Molecular Biology,2016,1434:153-167.
[3] TKACH M,THRY C.Communication by extracellular vesicles:where we are and where we need to go[J].Cell,2016,164(6):1226-1232.
[4] THRY C,ZITVOGEL L,AMIGORENA S. Exosomes:composition,biogenesis and function[J]. Nature Reviews Immunology,2002,2(8):569-579.
[5] KOECK E S,IORDANSKAIA T,SEVILLA S,et al.Adipocyte exosomes induce transforming growth factor beta pathway dysregulation in hepatocytes:a novel paradigm for obesity-related liver disease[J]. Journal of Surgical Research,2014,192(2):268-275.
[6] NOJIMA H,FREEMAN C M,SCHUSTER R M,et al. Hepatocyte exosomes mediate liver repair and regeneration via sphingosine-1-phosphate[J]. Journal of Hepatology,2016,64(1):60-68.
[7] ZHOU Y,WANG X,SUN L,et al. Toll-like receptor3-activated macrophages confer anti-HCV activity to hepatocytes through exosomes[J]. The FASEB Journal,2016,30(12):4132-4140.
[8] HUBER H J,HOLVOET P.Exosomes:emerging roles in communication between blood cells and vascular tissues during atherosclerosis[J]. Current Opinion in Lipidology,2015,26(5):412-419.
[9] DENG Z B,POLIAKOV A,HARDY R W,et al.Adipose tissue exosome-like vesicles mediate activation of macrophage-induced insulin resistance[J]. Diabetes,2009,58(11):2498-2505.
[10] FERRANTE S C,NADLER E P,PILLAI D K,et al.Adipocyte-derived exosomal miRNAs:a novel mechanism for obesity-related disease[J]. Pediatric Research,2015,77(3):447-454.
[11] LEE Y S,KIMS Y,KO E,et al. Exosomes derived from palmitic acid-treated hepatocytes induce fibrotic activation of hepatic stellate cells[J]. Scientific Reports,2017,7(1):3710.
[12] LEWIS A P,JOPLING C L.Regulation and biological function of the liver-specific miR-122[J].Biochemical Society Transactions,2010,38(6):1553-1557.
[13] BARANOVA A,MALTSEVA D,TONEVITSKY A.Adipose may actively delay progression of NAFLD by releasing tumor-suppressing,anti-fibrotic miR-122 into circulation[J]. Obesity Reviews,2019,20(1):108-118.
[14] ZHANG Y,YU M,TIAN W D. Physiological and pathological impact of exosomes of adipose tissue[J].Cell Proliferation,2016,49(1):3-13.
[15] HARDIE D G.The AMP-activated protein kinase cascade:the key sensor of cellular energy status[J]. Endocrinology,2003,144(12):5179-5183.
[16] VIOLLET B,FORETZ M,GUIGAS B,et al. Activation of AMP-activated protein kinase in the liver:a newstrategy for the management of metabolic hepatic disorders[J]. The Journal of Physiology,2006,574(1):41-53.
[17] LONG Y C,ZIERATH J R.AMP-activated protein kinase signaling in metabolic regulation[J]. The Journal of Clinical Investigation,2006,116(7):1776-1783.
[18] CANTC,GERHART-HINES Z,FEIGE J N,et al.AMPK regulates energy expenditure by modulating NAD+metabolism and SIRT1 activity[J]. Nature,2009,458(7241):1056-1060.
[19] LIU L,JIN X,HU C F,et al.Exosomes derived from mesenchymal stem cells rescue myocardial ischaemia/reperfusion injury by inducing cardiomyocyte autophagy via AMPK and Akt pathways[J]. Cellular Physiology and Biochemistry,2017,43(1):52-68.
[20] SARAKUL O,VATTANAVIBOON P,TANAKA Y,et al.Enhanced erythroid cell differentiation in hypoxic condition is in part contributed by miR-210[J]. Blood Cells,Molecules,and Diseases,2013,51(2):98-103.
[21]明鹏飞,黄莹莹,董妍丽,等. LKB1-AMPKα-SIRT1信号通路在奶牛脂肪组织脂代谢中的调控作用[J].生物技术通报,2019,35(2):176-181.
[22] CROOKENDEN MA,WALKER C G,PEIRIS H,et al. Short communication:proteins from circulating exosomes represent metabolic state in transition dairy cows[J]. Journal of Dairy Science,2016,99(9):7661-7668.
[23] MITCHELL MD,SCHOLZ-ROMERO K,REED S,et al. Plasma exosome profiles from dairy cows with divergent fertility phenotypes[J].Journal of Dairy Science,2016,99(9):7590-7601.
[24] KORNEK M,SCHUPPAN D.Microparticles:modulators and biomarkers of liver disease[J]. Journal of Hepatology,2012,57(5):1144-1146.
[25] LEMOINNE S,THABUT D,HOUSSET C,et al.The emerging roles of microvesicles in liver diseases[J].Nature Reviews Gastroenterology&Hepatology,2014,11(6):350-361.
[26] BALA S,PETRASEK J,MUNDKUR S,et al. Circulating microRNAs in exosomes indicate hepatocyte injury and inflammation in alcoholic,drug-induced,and inflammatory liver diseases[J]. Hepatology,2012,56(5):1946-1957.
[27] MOMEN-HERAVI F,BALA S,KODYS K,et al.Exosomes derived from alcohol-treated hepatocytes horizontally transfer liver specific miRNA-122 and sensitize monocytes to LPS[J].Scientific Reports,2015,5:9991.
[28] POVERO D,EGUCHI A,LI H Y,et al. Circulating extracellular vesicles with specific proteome and liver microRNAs are potential biomarkers for liver injury in experimental fatty liver disease[J].PLoS One,2014,9(12):e113651.
[29] ZHAO K,LIANG G X,SUN X,et al. Comparative miRNAome analysis revealed different miRNA expression profiles in bovine sera and exosomes[J].BMC Genomics,2016,17(1):630.
[30] LIU Y N,LOU G H,LI A C,et al.AMSC-derived exosomes alleviate lipopolysaccharide/D-galactosamineinduced acute liver failure by miR-17-mediated reduction of TXNIP/NLRP3 inflammasome activation in macrophages[J].EBioMedicine,2018,36:140-150.
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