亚甲基四氢叶酸还原酶基因多态性与妇科疾病相关性的研究进展
摘要
亚甲基四氢叶酸还原酶(MTHFR)是机体叶酸代谢过程中的关键酶,参与机体许多生理生化过程。MTHFR基因多态性导致的酶活性降低可导致叶酸代谢障碍,进而导致与该遗传特征相关的疾病易感。随着叶酸的研究关注度逐年提高,近年来有研究表明MTHFR基因多态性与妇科疾病的发生也有一定相关性,叶酸的补充对于普通妇女预防妇科疾病同样有重要的临床意义。
引文
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[9] MOHAMMADPOUR-GHAREHBAGH A,TEIMOORI B,NAROOEI-NEJAD M,et al. The association of the placental MTHFR 3′-UTR polymorphisms,promoter methylation,and MTHFR expression with preeclampsia[J]. J Cell Biochem,2018,119(2):1346-1354.
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[14] WANG L,XU W,WANG C,et al. Methylenetetrahydrofolate reductase C677T polymorphism and the risks of polycystic ovary syndrome:an updated meta-analysis of 14 studies[J]. Oncotarget,2017,8(35):59509-59517.
[15] YU L,CHANG K,HAN J,et al. Association between Methylenetetrahydrofolate Reductase C677T Polymorphism and Susceptibility to Cervical Cancer:A Meta-Analysis[J]. Plos One,2013,8(2):1-9.
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[17] YI K,YANG L,LAN Z,et al. The association between MTHFR polymorphisms and cervical cancer risk:a system review and meta analysis[J]. Arch Gynecol Obstet,2016,294(3):579-588.
[18] CHEN H,ZHU J. C677T polymorphism of methylenetetrahydrofolate reductase may contribute to cervical cancer risk in complete over-dominant model[J]. Med Hypotheses,2013,80(5):679-683.
[19] GONZáLEZ-HERRERA L,RODRíGUEZ-MORALES P,DEL REFUGIO GONZáLEZ-LOSA M,et al. MTHFR/p53 polymorphisms as genetic factors for cervical intraepithelial neoplasia and cervical cancer in HPV-infected Mexican women[J]. Int J Biol Markers,2014,29(2):142-149.
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[23] ROUSSOTTE F F,HUA X,NARR K L,et al. The C677T variant in MTHFR modulates associations between brain integrity,mood,and cognitive functioning in old age[J]. Biol Psychiatry Cogn Neurosci Neuroimaging,2017,2(3):280-288.
[24] RóZYCKA A,S?OPIEN R,S?OPIEN A,et al. The MAOA,COMT,MTHFR and ESR1 gene polymorphisms are associated with the risk of depression in menopausal women[J]. Maturitas,2016,84(10):42-54.
[25] YAN J,LIU Y,CAO L,et al. Association between duration of folic acid supplementation during pregnancy and risk of postpartum depression[J]. Nutrients,2017,9(11):1206.
[26] ZHANG L,LIU W,HAO Q,et al. Folate intake and methylenetetrahydrofolate reductase gene polymorphisms as predictive and prognostic biomarkers for ovarian cancer risk[J]. Int J Mol Sci,2012,13(4):4009-4020.
[27] HE L,SHEN Y. MTHFR C677T polymorphism and breast,ovarian cancer risk:a meta-analysis of 19,260 patients and 26,364 controls[J]. Onco Targets Ther,2017,10:227-238.
[28] LIU W,LI Y,LI R,et al. Association of mthfr a1298c polymorphism with breast cancer and/or ovarian cancer risk:an updated meta-analysis[J]. Afr J Tradit Complement Altern Med,2016,13(5):72-86.
[29] SHI X Y,SHEN Q. MTHFR A1298C polymorphism and ovarian cancer risk:a meta-analysis[J]. Genet Mol Res,2015,14(3):8211.
[30] LUONG D,KESHARWANI P,ALSAAB H O,et al. Folic acid conjugated polymeric micelles loaded with a curcumin difluorinated analog for targeting cervical and ovarian cancers[J]. Colloids Surf B Biointerfaces,2017,157:490-502.
[2] OZEK M A,KARAAGAOGLU E,ORGUL G,et al. Comparison of different types of twin pregnancies in terms of obstetric and perinatal outcomes:association of vanished twins with methylenetetrahydrofolate reductase(MTHFR)polymorphism(s)[J]. J Assist Reprod Gen,2018,35(12):2149-2154.
[3] MOUSSA H N,HOSSEINI N S,HAIDAR Z A,et al. Folic acid supplementation:what is new? Fetal,obstetric,long-term benefits and risks[J]. Future Sci OA,2016,2(2):O116.
[4] AOUN A,FADDOUL L,EL JABBOUR F,et al. Are the level of knowledge and practices of pregnant women regarding folic acid supplementation still inadequate? A cross-sectional study in a middle eastern urban setting[J]. J Diet Suppl,2018,15(5):692-703.
[5] GONG J,SHEN Y,SHAN W,et al. The association between MTHFR polymorphism and cervical cancer[J]. Sci Rep,2018,8(1).
[6] ACHOUR O,ELMTAOUA S,ZELLAMA D,et al. The C677T MTHFR genotypes influence the efficacy of B9 and B12 vitamins supplementation to lowering plasma total homocysteine in hemodialysis[J]. J Nephrol,2016,29(5):691-698.
[7] CETIN O,KARAMAN E,CIM N,et al. The impact of low molecular weight heparin on obstetric outcomes among unexplained recurrent miscarriages complicated with methylenetetrahydrofolate reductase gene polymorphism[J]. Ginekol Pol,2017,88(5):260-265.
[8] FANG Q,JIANG Y,LIU Z,et al. Systematic review and metaanalysis of the associations between maternal methylenetetrahydrofolate reductase polymorphisms and preterm delivery[J]. J Obstet Gynaecol Res,2018,44(4):663-672.
[9] MOHAMMADPOUR-GHAREHBAGH A,TEIMOORI B,NAROOEI-NEJAD M,et al. The association of the placental MTHFR 3′-UTR polymorphisms,promoter methylation,and MTHFR expression with preeclampsia[J]. J Cell Biochem,2018,119(2):1346-1354.
[10] MENG Y,CHEN X,PENG Z,et al. Association between high serum homocysteine levels and biochemical characteristics in Women with Polycystic Ovarian Syndrome:A Systematic Review and Meta-Analysis[J]. Plos One,2016,11(6):e157389.
[11] WOLF W,WATTICK R,KINKADE O,et al. Geographical prevalence of polycystic ovary syndrome as determined by region and race/ethnicity[J]. Int J Environ Res Public Health,2018,15(11):2589.
[12] FU L,DAI L,LI X,et al. Association of methylenetetrahydrofolate reductase gene C677T polymorphism with polycystic ovary syndrome risk:a systematic review and meta-analysis update[J]. Eur J Obstet Gynecol Reprod Biol,2014,172:56-61.
[13] JIAO X,CHEN W,ZHANG J,et al. Variant alleles of the ESR1,PPARG,HMGA2,and MTHFR genes are associated with polycystic ovary syndrome risk in a Chinese population:A Case-Control Study[J]. Front Endocrinol,2018,9(54):1-15.
[14] WANG L,XU W,WANG C,et al. Methylenetetrahydrofolate reductase C677T polymorphism and the risks of polycystic ovary syndrome:an updated meta-analysis of 14 studies[J]. Oncotarget,2017,8(35):59509-59517.
[15] YU L,CHANG K,HAN J,et al. Association between Methylenetetrahydrofolate Reductase C677T Polymorphism and Susceptibility to Cervical Cancer:A Meta-Analysis[J]. Plos One,2013,8(2):1-9.
[16] HAJIESMAEIL M,TAFVIZI F,SARMADI S. The effect of methylenetetrahydrofolate reductase polymorphisms on susceptibility to human papilloma virus infection and cervical cancer[J]. Infect Genet Evol,2016,46:1-6.
[17] YI K,YANG L,LAN Z,et al. The association between MTHFR polymorphisms and cervical cancer risk:a system review and meta analysis[J]. Arch Gynecol Obstet,2016,294(3):579-588.
[18] CHEN H,ZHU J. C677T polymorphism of methylenetetrahydrofolate reductase may contribute to cervical cancer risk in complete over-dominant model[J]. Med Hypotheses,2013,80(5):679-683.
[19] GONZáLEZ-HERRERA L,RODRíGUEZ-MORALES P,DEL REFUGIO GONZáLEZ-LOSA M,et al. MTHFR/p53 polymorphisms as genetic factors for cervical intraepithelial neoplasia and cervical cancer in HPV-infected Mexican women[J]. Int J Biol Markers,2014,29(2):142-149.
[20] ALSBEIH G A,AL-HARBI N M,BIN JUDIA S S,et al. Reduced rate of human papillomavirus infection and genetic overtransmission ofTP53 72C polymorphic variant lower cervical cancer incidence[J]. Cancer,2017,123(13):2459-2466.
[21] WEINSTOCK N I,WRABETZ L,FELTRI M L,et al. Metabolic profiling reveals biochemical pathways and potential biomarkers associated with the pathogenesis of Krabbe disease[J]. J Neurosci Res,2016,94(11):1094-1107.
[22] WAN L,LI Y,ZHANG Z,et al. Methylenetetrahydrofolate reductase and psychiatric diseases[J]. Transl Psychiat,2018,8(1).
[23] ROUSSOTTE F F,HUA X,NARR K L,et al. The C677T variant in MTHFR modulates associations between brain integrity,mood,and cognitive functioning in old age[J]. Biol Psychiatry Cogn Neurosci Neuroimaging,2017,2(3):280-288.
[24] RóZYCKA A,S?OPIEN R,S?OPIEN A,et al. The MAOA,COMT,MTHFR and ESR1 gene polymorphisms are associated with the risk of depression in menopausal women[J]. Maturitas,2016,84(10):42-54.
[25] YAN J,LIU Y,CAO L,et al. Association between duration of folic acid supplementation during pregnancy and risk of postpartum depression[J]. Nutrients,2017,9(11):1206.
[26] ZHANG L,LIU W,HAO Q,et al. Folate intake and methylenetetrahydrofolate reductase gene polymorphisms as predictive and prognostic biomarkers for ovarian cancer risk[J]. Int J Mol Sci,2012,13(4):4009-4020.
[27] HE L,SHEN Y. MTHFR C677T polymorphism and breast,ovarian cancer risk:a meta-analysis of 19,260 patients and 26,364 controls[J]. Onco Targets Ther,2017,10:227-238.
[28] LIU W,LI Y,LI R,et al. Association of mthfr a1298c polymorphism with breast cancer and/or ovarian cancer risk:an updated meta-analysis[J]. Afr J Tradit Complement Altern Med,2016,13(5):72-86.
[29] SHI X Y,SHEN Q. MTHFR A1298C polymorphism and ovarian cancer risk:a meta-analysis[J]. Genet Mol Res,2015,14(3):8211.
[30] LUONG D,KESHARWANI P,ALSAAB H O,et al. Folic acid conjugated polymeric micelles loaded with a curcumin difluorinated analog for targeting cervical and ovarian cancers[J]. Colloids Surf B Biointerfaces,2017,157:490-502.