百令胶囊联合优甲乐治疗自身免疫性甲状腺炎疗效分析
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摘要
目的探究百令胶囊联合优甲乐治疗自身免疫性甲状腺炎的临床疗效。方法选取128例自身免疫性甲状腺炎患者,随机分为观察组(64例)与对照组(64例)。对照组口服优甲乐治疗,观察组口服百令胶囊+优甲乐治疗,对比两组临床疗效和甲状腺功能变化。结果治疗前两组促甲状腺素(TSH)、血清游离三碘甲腺原氨酸(FT3)及游离甲状腺素(FT4)与抗甲状腺过氧化物酶抗体(TPO Ab)及甲状腺球蛋白抗体(TG Ab)比较均无显著性差异(P>0.05);连续用药3个月后,两组FT3、FT4水平较治疗前显著升高(P<0.05),而TSH、TPO Ab及TG Ab水平较治疗前显著降低(P<0.05)。观察组总有效率和显效率(68.75%、26.56%)均显著高于对照组(45.32%、10.94%)(P<0.05);两组不良反应发生率比较无显著差异(P>0.05)。结论百令胶囊联合优甲乐治疗自身免疫性甲状腺炎可显著改善甲状腺功能,提高治疗效果,可作为首选辅助治疗手段应用于临床。
Objective To explore the clinical efficacy of Bailing capsule combined with Euthyrox in the treatment of autoimmune thyroiditis. Methods A total of 128 patients with autoimmune thyroiditis were randomly divided into an observation group and a control group(n =64, respectively). The control group was treated with Euthyrox orally, and the observation group was treated with Bailing capsule plus Euthyrox orally. The clinical efficacy and thyroid function were compared between the two groups.Results Before the treatment, there were no significant differences between the two groups in thyroid-stimulating hormone(TSH),serum free triiodothyronine(FT3) and free thyroxine(FT4), thyroid peroxidase antibody(TPO Ab) and thyroid globulin antibody(TG Ab). After three months of treatment, the levels of FT3 and FT4 in the two groups were significantly higher than those before the treatment(P < 0.05), while TSH, TPO Ab and TG Ab levels were significantly lower than those before the treatment(P < 0.05). The total effective rate and effective rate(68.75% and 26.56%) of the observation group were significantly higher than those in the control group(45.32% and 10.94%)(P < 0.05), and there was no significant difference in the incidence of adverse reactions between the two groups(P > 0.05). Conclusion Bailing capsule combined with Euthyrox in the treatment of autoimmune thyroiditis can significantly improve the thyroid function and improve the clinical efficacy. It can be used as the first choice for clinical treatment.
Objective To explore the clinical efficacy of Bailing capsule combined with Euthyrox in the treatment of autoimmune thyroiditis. Methods A total of 128 patients with autoimmune thyroiditis were randomly divided into an observation group and a control group(n =64, respectively). The control group was treated with Euthyrox orally, and the observation group was treated with Bailing capsule plus Euthyrox orally. The clinical efficacy and thyroid function were compared between the two groups.Results Before the treatment, there were no significant differences between the two groups in thyroid-stimulating hormone(TSH),serum free triiodothyronine(FT3) and free thyroxine(FT4), thyroid peroxidase antibody(TPO Ab) and thyroid globulin antibody(TG Ab). After three months of treatment, the levels of FT3 and FT4 in the two groups were significantly higher than those before the treatment(P < 0.05), while TSH, TPO Ab and TG Ab levels were significantly lower than those before the treatment(P < 0.05). The total effective rate and effective rate(68.75% and 26.56%) of the observation group were significantly higher than those in the control group(45.32% and 10.94%)(P < 0.05), and there was no significant difference in the incidence of adverse reactions between the two groups(P > 0.05). Conclusion Bailing capsule combined with Euthyrox in the treatment of autoimmune thyroiditis can significantly improve the thyroid function and improve the clinical efficacy. It can be used as the first choice for clinical treatment.
引文
[1]方永碧,何德全.地塞米松联合甲巯咪唑治疗慢性自身免疫性甲状腺炎的临床研究[J].中国临床药理学杂志,2017,33(22):2250-2253.
[2]Baser H,Can U,Baser S,et al.Assesment of oxidative status and its association with thyroid autoantibodies in patients with euthyroid autoimmune thyroiditis[J].Endocrine,2015,48(3):1-8.
[3]陈专心.自拟消瘿方联合优甲乐治疗自身免疫性甲状腺炎合并甲状腺功能减退33例[J].浙江中西医结合杂志,2015,25(12):1116-1118.
[4]Cai DM,Wang HY,Yong J,et al.Primary follicular thyroid carcinoma metastasis to the kidney and widespread dissemination:a case report[J].Oncology Letters,2016,11(5):3293-3297.
[5]李继华,曹淑芝.免疫因子联合疗法治疗自身免疫性甲状腺疾病116例患者临床分析[J].中医临床研究,2015,7(27):40-42.
[6]中华医学会内分泌学分会《中国甲状腺疾病诊治指南》编写组.中国甲状腺疾病诊治指南——甲状腺炎[J].中华内科杂志,2008,47(9):867-868.
[7]Parameswaran A,Attwood K,Sato R,et al.Identification of a new disease cluster of pemphigus vulgaris with autoimmune thyroid disease,rheumatoid arthritis and type I diabetes[J].Br J Dermatol,2015,172(3):729-738.
[8]Hoermann R,Midgley JEM,Larisch R,et al.Relational stability of thyroid hormones in euthyroid subjects and patients with autoimmune thyroid disease[J].European Thyroid Journal,2016,5(3):171-179.
[9]袁永红.替米沙坦与百灵胶囊联合应用方案治疗51例早期Ⅱ型糖尿病肾病的临床疗效观察[J].航空航天医学杂志,2017,28(3):270-272.
[10]赵淞,苏苹,何宇梅,等.百令胶囊配合舒利迭治疗慢性阻塞性肺疾病的效果观察[J].中国老年保健医学,2014,12(2):43-44.
[11]Chaudhary S,Dutta D,Kumar M,et al.Vitamin D supplementation reduces thyroid peroxidase antibody levels in patients with autoimmune thyroid disease:an open-labeled randomized controlled trial[J].Indian Journal of Endocrinology&Metabolism,2016,20(3):391-398.
[12]高瑛,刘胜凤,张成华.碘对自身免疫性甲状腺疾病大鼠血清与甲状腺组织IP-10 m RNA表达的影响[J].中国老年学杂志,2017,37(13):3135-3137.
[13]Wang J,Lv S,Chen G,et al.Meta-analysis of the association between vitamin D and autoimmune thyroid disease[J].Nutrients,2015,7(4):2485-2498.
[14]李晓雯,廖春分,陈思思,等.百令胶囊口服联合曲安奈德局部注射治疗桥本氏甲状腺炎的疗效观察[J].中南医学科学杂志,2016,44(3):319-322.
[15]张玮.百令胶囊对桥本甲状腺炎患者过氧化物酶抗体的影响[J].实用临床医学,2015,16(4):23-24.
[16]Degner D,Haust M,Meller J,et al.Association between autoimmune thyroiditis and depressive disorder in psychiatric outpatients[J].European Archives of Psychiatry&Clinical Neuroscience,2015,265(1):67-72.
[17]韩家凯,苏冬月,庞妩燕,等.百令胶囊辅助治疗对Graves病的疗效观察[J].中医临床研究,2017,9(19):21-23.
[2]Baser H,Can U,Baser S,et al.Assesment of oxidative status and its association with thyroid autoantibodies in patients with euthyroid autoimmune thyroiditis[J].Endocrine,2015,48(3):1-8.
[3]陈专心.自拟消瘿方联合优甲乐治疗自身免疫性甲状腺炎合并甲状腺功能减退33例[J].浙江中西医结合杂志,2015,25(12):1116-1118.
[4]Cai DM,Wang HY,Yong J,et al.Primary follicular thyroid carcinoma metastasis to the kidney and widespread dissemination:a case report[J].Oncology Letters,2016,11(5):3293-3297.
[5]李继华,曹淑芝.免疫因子联合疗法治疗自身免疫性甲状腺疾病116例患者临床分析[J].中医临床研究,2015,7(27):40-42.
[6]中华医学会内分泌学分会《中国甲状腺疾病诊治指南》编写组.中国甲状腺疾病诊治指南——甲状腺炎[J].中华内科杂志,2008,47(9):867-868.
[7]Parameswaran A,Attwood K,Sato R,et al.Identification of a new disease cluster of pemphigus vulgaris with autoimmune thyroid disease,rheumatoid arthritis and type I diabetes[J].Br J Dermatol,2015,172(3):729-738.
[8]Hoermann R,Midgley JEM,Larisch R,et al.Relational stability of thyroid hormones in euthyroid subjects and patients with autoimmune thyroid disease[J].European Thyroid Journal,2016,5(3):171-179.
[9]袁永红.替米沙坦与百灵胶囊联合应用方案治疗51例早期Ⅱ型糖尿病肾病的临床疗效观察[J].航空航天医学杂志,2017,28(3):270-272.
[10]赵淞,苏苹,何宇梅,等.百令胶囊配合舒利迭治疗慢性阻塞性肺疾病的效果观察[J].中国老年保健医学,2014,12(2):43-44.
[11]Chaudhary S,Dutta D,Kumar M,et al.Vitamin D supplementation reduces thyroid peroxidase antibody levels in patients with autoimmune thyroid disease:an open-labeled randomized controlled trial[J].Indian Journal of Endocrinology&Metabolism,2016,20(3):391-398.
[12]高瑛,刘胜凤,张成华.碘对自身免疫性甲状腺疾病大鼠血清与甲状腺组织IP-10 m RNA表达的影响[J].中国老年学杂志,2017,37(13):3135-3137.
[13]Wang J,Lv S,Chen G,et al.Meta-analysis of the association between vitamin D and autoimmune thyroid disease[J].Nutrients,2015,7(4):2485-2498.
[14]李晓雯,廖春分,陈思思,等.百令胶囊口服联合曲安奈德局部注射治疗桥本氏甲状腺炎的疗效观察[J].中南医学科学杂志,2016,44(3):319-322.
[15]张玮.百令胶囊对桥本甲状腺炎患者过氧化物酶抗体的影响[J].实用临床医学,2015,16(4):23-24.
[16]Degner D,Haust M,Meller J,et al.Association between autoimmune thyroiditis and depressive disorder in psychiatric outpatients[J].European Archives of Psychiatry&Clinical Neuroscience,2015,265(1):67-72.
[17]韩家凯,苏冬月,庞妩燕,等.百令胶囊辅助治疗对Graves病的疗效观察[J].中医临床研究,2017,9(19):21-23.