山腊梅叶健脾汤治疗慢性阻塞性肺疾病急性加重期对肺功能、血清氧化应激指标的影响
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摘要
目的:探讨山腊梅叶健脾汤治疗慢性阻塞性肺疾病急性加重期(AECOPD)患者对肺功能、血清氧化应激指标的影响。方法:选取医院(2016年1月—2017年9月)收集的140例AECOPD患者,采用随机数字表法分为中西医组和西医组各70例,两组患者均给予抗感染、祛痰、吸氧等基础治疗,中西医组同时服用山腊梅叶健脾汤治疗,对比两组的治疗效果。结果:治疗前,两组患者的血清MDA、8-OHdG、PC、TAC水平差异不具有统计学意义(P>0.05);治疗后,中西医组的TAC水平显著的高于西医组(P<0.05),中西医组的MDA、8-OHdG、PC水平显著的低于西医组(P<0.05);治疗前,两组患者的PaO_2、PaCO_2差异不具有统计学意义(P>0.05);治疗后,中西医组的PaO_2显著的高于西医组(P<0.05),中西医组的PaCO2显著的低于西医组(P<0.05);治疗前,两组患者的FEV1、FEV1%、PEFR差异不具有统计学意义(P>0.05);治疗后,中西医组的FEV1、FEV1%、PEFR显著的高于西医组(P<0.05)。结论:山腊梅叶健脾汤辅助治疗AECOPD患者效果较好,能显著的降低氧化应激水平,改善肺功能。
Objective: To investigate the effect of Sanla Meiye Jianpi Decoction on pulmonary function and serum oxidative stress in patients with acute exacerbation of chronic obstructive pulmonary disease( AECOPD). Methods: A total of140 patients with AECOPD collected in our hospital( 2016. 1-2017. 9) were randomly divided into Chinese and Western medicine group and western medicine group. The two groups were given basic treatment such as anti-infection,sputum and oxygen. The Chinese and Western medicine group took Shanla Meijian Jianpi Decoction at the same time and compared the treatment effects of the two groups. Results: Before treatment,serum MDA,8-OHdG,PC and TAC levels were not statistically different between the two groups( P > 0. 05). After treatment,TAC levels in Chinese and Western medicine groups were significantly higher than those in Western medicine group( P < 0. 05). The levels of MDA,8-OHdG and PC in the Chinese and Western medicine groups were significantly lower than those in the Western medicine group( P < 0. 05). Before treatment,the PaO 2 and PaC O2 levels of the two groups were not statistically different( P >0. 05). The PaO 2 of the Chinese and Western medicine group was significantly higher than that of the Western medicine group( P < 0. 05). The PaC O2 of the Chinese and Western medicine group was significantly lower than that of the Western medicine group( P < 0. 05). Before treatment,the differences in FEV1,FEV1% and PEFR between the two groups did not exist( P > 0. 05). After treatment,FEV1,FEV1% and PEFR in the Chinese and Western medicine groups were significantly higher than those in the Western medicine group( P < 0. 05). Conclusion: The treatment of patients with AECOPD with Shanla Meiye Jianpi Decoction can significantly improve the patients' antioxidant and lung function.
Objective: To investigate the effect of Sanla Meiye Jianpi Decoction on pulmonary function and serum oxidative stress in patients with acute exacerbation of chronic obstructive pulmonary disease( AECOPD). Methods: A total of140 patients with AECOPD collected in our hospital( 2016. 1-2017. 9) were randomly divided into Chinese and Western medicine group and western medicine group. The two groups were given basic treatment such as anti-infection,sputum and oxygen. The Chinese and Western medicine group took Shanla Meijian Jianpi Decoction at the same time and compared the treatment effects of the two groups. Results: Before treatment,serum MDA,8-OHdG,PC and TAC levels were not statistically different between the two groups( P > 0. 05). After treatment,TAC levels in Chinese and Western medicine groups were significantly higher than those in Western medicine group( P < 0. 05). The levels of MDA,8-OHdG and PC in the Chinese and Western medicine groups were significantly lower than those in the Western medicine group( P < 0. 05). Before treatment,the PaO 2 and PaC O2 levels of the two groups were not statistically different( P >0. 05). The PaO 2 of the Chinese and Western medicine group was significantly higher than that of the Western medicine group( P < 0. 05). The PaC O2 of the Chinese and Western medicine group was significantly lower than that of the Western medicine group( P < 0. 05). Before treatment,the differences in FEV1,FEV1% and PEFR between the two groups did not exist( P > 0. 05). After treatment,FEV1,FEV1% and PEFR in the Chinese and Western medicine groups were significantly higher than those in the Western medicine group( P < 0. 05). Conclusion: The treatment of patients with AECOPD with Shanla Meiye Jianpi Decoction can significantly improve the patients' antioxidant and lung function.
引文
[1] 杨彦斌, 黄文睿. 肺肠同治法对慢性阻塞性肺疾病急性加重期炎症及相关生化指标的影响[J]. 吉林中医药, 2018(3):293-296.
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[9] 黄文华, 徐英妹, 蒋凌飞, 等. 温阳定喘方联合西药治疗慢性阻塞性肺疾病急性加重期疗效观察[J]. 广西中医药, 2018(1):6-8.
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[11] 李诗国, 戴圣伟, 吕艳叶, 等. 山腊梅叶健脾汤对急性加重期慢性阻塞性肺疾病T淋巴细胞亚群的影响[J]. 中华中医药学刊, 2016,34(11):2811-2814.
[12] 柳智龙. 小陷胸汤合苇茎汤加味治疗慢性阻塞性肺疾病急性加重期疗效观察[J]. 亚太传统医药, 2018(3):171-172.
[13] 李姗姗, 王胜. 益肺健脾法治疗慢性阻塞性肺疾病研究进展[J]. 中医药临床杂志, 2018(1):31-34.
[14] 李诗国, 李武峰. 山腊梅叶煎剂治疗慢性萎缩性胃炎癌前病变48例临床观察[J]. 浙江中医杂志, 2017(6):415.
[15] 张福娴. 中医综合治疗慢性阻塞性肺疾病稳定期60例[J]. 中医研究, 2018(2):14-16.
[16] 张鸿雁, 古春颖, 李霞. 三子养亲汤加味治疗慢性阻塞性肺疾病稳定期临床研究[J]. 世界中医药, 2017,12(3):558-561.
[17] 徐福松, 赵伟, 章茂森. 从痰论治男科疾病钩玄[J]. 江苏中医药, 2018(2):1-4.
[18] 李梦頔, 黄世敬. 培元通滞法治疗双心疾病探讨[J]. 中医学报, 2018(1):80-83.
[19] 马啸, 吕福全. 《丹溪心法》对经络证治的学术贡献[J]. 天津中医药大学学报, 2017,36(3):178-179.
[20] 杨昌邦, 高博, 高兴亮, 等. 慢性阻塞性肺疾病中西医结合治疗研究进展[J]. 湖北民族学院学报(医学版), 2018(1):191-193.
[21] 王海宇, 王胜. 中医药治疗慢性阻塞性肺疾病研究进展[J]. 中医药临床杂志, 2018(2):201-204.
[22] 刘佳玉, 石克华. 中医药治疗慢性阻塞性肺疾病急性加重期研究进展[J]. 河北中医, 2018(1):146-151.
[23] Barreiro E, Gea J, Matar G, et al. Expression and Carbonylation of Creatine Kinase in the Quadriceps Femoris Muscles of Patients with Chronic Obstructive Pulmonary Disease[J]. American Journal of Respiratory Cell & Molecular Biology, 2005,33(6):636.
[2] 胡亚洁, 赵晓锦. 中西医结合治疗痰热壅肺型慢性阻塞性肺疾病急性加重期临床观察[J]. 山东中医药大学学报, 2018(1):58-60.
[3] 胡大清, 罗秋红. 百令胶囊联合注射用细辛脑治疗慢性阻塞性肺疾病急性加重期的疗效观察[J]. 现代药物与临床, 2018(3):513-517.
[4] 陈荣昌. 慢性阻塞性肺疾病最新诊治和研究进展[J]. 华西医学, 2018(1):15-18.
[5] 陈冬, 高凌杰, 高畅, 等. 血必净注射液对AECOPD的炎症因子及超敏C反应蛋白的影响[J]. 淮海医药, 2018(2):200-202.
[6] 胡大清, 罗秋红. 百令胶囊联合注射用细辛脑治疗慢性阻塞性肺疾病急性加重期的疗效观察[J]. 现代药物与临床, 2018(3):513-517.
[7] 吴成明, 程玉峰, 赵园园. 桑白皮汤对慢性阻塞性肺疾病急性加重期(痰热郁肺证)患者氧化应激的影响[J]. 中国中医急症, 2018(2):212-215.
[8] 唐晓, 李泽庚. 中医药干预COPD大鼠模型实验研究进展[J]. 中医药临床杂志, 2017(11):1948-1951.
[9] 黄文华, 徐英妹, 蒋凌飞, 等. 温阳定喘方联合西药治疗慢性阻塞性肺疾病急性加重期疗效观察[J]. 广西中医药, 2018(1):6-8.
[10] 郭娜娜, 刘学军, 杜毓峰. 慢性阻塞性肺疾病的治疗进展[J]. 中华老年病研究电子杂志, 2017(4):28-32.
[11] 李诗国, 戴圣伟, 吕艳叶, 等. 山腊梅叶健脾汤对急性加重期慢性阻塞性肺疾病T淋巴细胞亚群的影响[J]. 中华中医药学刊, 2016,34(11):2811-2814.
[12] 柳智龙. 小陷胸汤合苇茎汤加味治疗慢性阻塞性肺疾病急性加重期疗效观察[J]. 亚太传统医药, 2018(3):171-172.
[13] 李姗姗, 王胜. 益肺健脾法治疗慢性阻塞性肺疾病研究进展[J]. 中医药临床杂志, 2018(1):31-34.
[14] 李诗国, 李武峰. 山腊梅叶煎剂治疗慢性萎缩性胃炎癌前病变48例临床观察[J]. 浙江中医杂志, 2017(6):415.
[15] 张福娴. 中医综合治疗慢性阻塞性肺疾病稳定期60例[J]. 中医研究, 2018(2):14-16.
[16] 张鸿雁, 古春颖, 李霞. 三子养亲汤加味治疗慢性阻塞性肺疾病稳定期临床研究[J]. 世界中医药, 2017,12(3):558-561.
[17] 徐福松, 赵伟, 章茂森. 从痰论治男科疾病钩玄[J]. 江苏中医药, 2018(2):1-4.
[18] 李梦頔, 黄世敬. 培元通滞法治疗双心疾病探讨[J]. 中医学报, 2018(1):80-83.
[19] 马啸, 吕福全. 《丹溪心法》对经络证治的学术贡献[J]. 天津中医药大学学报, 2017,36(3):178-179.
[20] 杨昌邦, 高博, 高兴亮, 等. 慢性阻塞性肺疾病中西医结合治疗研究进展[J]. 湖北民族学院学报(医学版), 2018(1):191-193.
[21] 王海宇, 王胜. 中医药治疗慢性阻塞性肺疾病研究进展[J]. 中医药临床杂志, 2018(2):201-204.
[22] 刘佳玉, 石克华. 中医药治疗慢性阻塞性肺疾病急性加重期研究进展[J]. 河北中医, 2018(1):146-151.
[23] Barreiro E, Gea J, Matar G, et al. Expression and Carbonylation of Creatine Kinase in the Quadriceps Femoris Muscles of Patients with Chronic Obstructive Pulmonary Disease[J]. American Journal of Respiratory Cell & Molecular Biology, 2005,33(6):636.