空气污染物对哮喘相关基因DNA甲基化调控的研究进展
摘要
<正>新近大量研究证实,空气污染物与儿童哮喘发生、发展关系密切。空气污染物包括颗粒物(PM),O_3、SO_2、NO_x、CO、苯等。其中,颗粒物指生物颗粒(花粉、真菌孢子、细菌等)、土壤颗粒和烟雾颗粒等混合物;主要分为可吸入颗粒物(PM10,空气动力学直径<10μm)以及细颗粒物(PM2.5,空气动力学
引文
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[25]Daskalos A,Nikolaidis G,G,Savvari P,et al.Hypomethylation of retrotransposable elements correlates with genomic instability in non-small cell lung cancer[J].International Journal of Cancer,2010,124(1):81.
[26]付艳云,梁戈玉.环境颗粒物的表观遗传学研究进展[J].东南大学学报(医学版),2014,33(1):90.
[27]Breton CV,Hyang-Min B,Made W,et al.Prenatal tobacco smoke exposure affects global and gene-specific DNA methylation[J].American journal of respiratory and critical care medicine,2009,180(5):462.
[2]王莹,宋磊,丁会.环境PM2.5暴露与支气管哮喘的研究进展[J].中国实验诊断学,2017,21(7):1269.
[3]Lee A,Leon Hsu HH,Mathilda Chiu YH,et al.Prenatal fine particulate exposure and early childhood asthma:Effect of maternal stress and fetal gender[J].Journal of Allergy&Clinical Immunology,2018,141(5):1880.
[4]Ji H,Myers JMB,Brandt EB,et al.Air pollution,epigenetics,and asthma[J].Allergy Asthma&Clinical Immunology Official Journal of the Canadian Society of Allergy&Clinical Immunology,2016,12(1):51.
[5]陈冉,孟玲,武伟华,等.基因甲基化对哮喘Th1/Th2相关细胞因子表达的影响研究[J].中国地方病防治杂志,2016(3):322.
[6]Marie-Abele B,Johanna L,Antonella Z,et al.Air pollution and gene-specific methylation in the normative aging study:Association,effect modification,and mediation analysis[J].Epigenetics,2014,9(3):448.
[7]Brand S,Kesper DA,Teich R,et al.DNA methylation of t h 1/t h2cytokine genes affects sensitization and progress of experimental asthma[J].Journal of Allergy&Clinical Immunology,2012,129(6):1602.
[8]Cole E,Brown TA,Pinkerton KE,et al.Perinatal exposure to environmental tobacco smoke is associated with changes in DNAmethylation that precede the adult onset of lung disease in a mouse model[J].Inhalation Toxicology,2017,29(10):435.
[9]Torrone DZ,Kuriakose J S,Moors K,et al..Reproducibility and intraindividual variation over days in buccal cell DNA methylation of two asthma genes,interferonγ(ifnγ)and inducible nitric oxide synthase(inos)[J].Clinical epigenetics,2012,4(1):3.
[10]Yue H,Yan W,Ji X,et al.Maternal exposure of balb/c mice to indoor no2and allergic asthma syndrome in offspring at adulthood with evaluation of DNA methylation associated th2polarization[J].Environmental Health Perspectives,2017,125(9):097011.
[11]Liu J,Ballaney M,Alalem U,et al.Combined inhaled diesel exhaust particles and allergen exposure alter methylation of t helper genes and ige production in vivo[J].Toxicological Sciences,2008,102(1):76.
[12]Prunicki M,Stell L,Dinakarpandian D,et al.Exposure to no 2,co,and pm 2.5is linked to regional DNA methylation differences in asthma[J].Clinical epigenetics,2018,10(1):2.
[13]Yu Y,Wang L,Gu G.The correlation between runx3and bronchial asthma[J].Clinica chimica acta,2018,487:75.
[14]郑鑫,张志红.空气污染物对哮喘相关基因DNA甲基化影响的研究进展[J].环境与职业医学,2016,33(8):795.
[15]Brandt EB,Kovacic MB,Lee GB,et al.Diesel exhaust particle induction of il-17acontributes tosevere asthma[J].J Allergy Clin Immunol,2013,132(5):1194.
[16]Castaneda AR,Vogel CFA,Bein KJ,et al.Ambient particulate matter enhances the pulmonary allergic immune response to house dust mite in a balb/c mouse model by augmenting th2-and th17-immune responses[J].Physiological Reports,2018,6(18):e13827.
[17]Martin EM,Fry RC.Environmental influences on the epigenome:Exposure-associated DNA methylation in human populations[J].Annu Rev Public Health,2018,39:309.
[18]Somineni HK,Zhang X,Biagini Myers JM,et al.Ten-eleven translocation 1(tet1)methylation is associated with childhood asthma and traffic-related air pollution[J].Journal of Allergy&Clinical Immunology,2016,137(3):797.
[19]Tarantini L,Bonzini M,Apostoli P,et al.Effects of particulate matter on genomic DNA methylation content and inos promoter methylation[J].Environmental Health Perspectives,2009,117(2):217.
[20]Ding R,Jin Y,Liu X,et al.Dose-and time-effect responses of DNA methylation and histone h3k9acetylation changes induced by traffic-related air pollution[J].Scientific Reports,2017,7:43737.
[21]Frederica P,Wan-Yee T,Julie H,et al.Relation of DNA methylation of 5'-cpg island of acsl3to transplacental exposure to airborne polycyclic aromatic hydrocarbons and childhood asthma[J].Plos One,2009,4(2):e4488.
[22]Gao L,Millstein J,Siegmund KD,et al.Epigenetic regulation of axl and risk of childhood asthma symptoms[J].Clinical epigenetics,2017,9:121.
[23]Breton CV,Salam MT,Gilliland FD.Heritability and role for the environment in DNA methylation in axl receptor tyrosine kinase[J].Epigenetics,2011,6(7):895.
[24]Salam MT,Ying Z,Kohinoor B.Epigenetics and childhood asthma:Current evidence and future research directions[J].Epigenomics,2012,4(4):415.
[25]Daskalos A,Nikolaidis G,G,Savvari P,et al.Hypomethylation of retrotransposable elements correlates with genomic instability in non-small cell lung cancer[J].International Journal of Cancer,2010,124(1):81.
[26]付艳云,梁戈玉.环境颗粒物的表观遗传学研究进展[J].东南大学学报(医学版),2014,33(1):90.
[27]Breton CV,Hyang-Min B,Made W,et al.Prenatal tobacco smoke exposure affects global and gene-specific DNA methylation[J].American journal of respiratory and critical care medicine,2009,180(5):462.