迁移侵袭抑制蛋白MIIP与肿瘤的研究进展
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摘要
迁移侵袭抑制蛋白(MIIP)基因是近年来新发现的一种抑癌基因,与多种人类肿瘤发生进展关系密切。它主要通过与胰岛素样生长因子结合蛋白2 (IGFBP2)、组蛋白去乙酰化酶6(HDAC6)结合调控肿瘤细胞的迁移、侵袭。本文主要围绕MIIP与肿瘤的关系,及其作用机制进行归纳总结。目的在全面了解MIIP对肿瘤影响的基础上,为抗肿瘤治疗提供新思路辅助临床治疗。
The migration and invasion inhibitory protein(MIIP) gene is a newly identified tumor suppressor gene in recent years, and it is closely associated with the tumorigenesis of various human tumors. MIIP mainly regulates the migration and invasion of tumor cell by interacting with insulin-like growth factor binding protein 2(IGFBP-2) and histone deacetylase 6(HDAC6). This article focuses on the relationship between MIIP and tumor, and summarizes its mechanism of action. It attempts to provide a novel ideal for anti-tumor treatment to assist clinical therapy based on a comprehensive analysis of the effects of MIIP on tumors.
The migration and invasion inhibitory protein(MIIP) gene is a newly identified tumor suppressor gene in recent years, and it is closely associated with the tumorigenesis of various human tumors. MIIP mainly regulates the migration and invasion of tumor cell by interacting with insulin-like growth factor binding protein 2(IGFBP-2) and histone deacetylase 6(HDAC6). This article focuses on the relationship between MIIP and tumor, and summarizes its mechanism of action. It attempts to provide a novel ideal for anti-tumor treatment to assist clinical therapy based on a comprehensive analysis of the effects of MIIP on tumors.
引文
[1] SONG F, ZHANG L, JI P, et al. Altered expression and loss of heterozygosity of the migration and invasion inhibitory protein(MIIP)gene in breast cancer[J]. Oncol Rep, 2015, 33(6):2771-2778.
[2] ZHOU HP, QIAN LX, ZHANG N, et al. MIIP gene expression is associated with radiosensitivity in human nasopharyngeal carcinoma cells[J]. Oncol Lett, 2018, 15(6):9471-9479.
[3] SONG SW, FULLER GN, KHAN A, et al. IIp45, an insulin-like growth factor binding protein 2(IGFBP-2)binding protein, antagonizes IGFBP-2 stimulation of glioma cell invasion[J]. Proc Natl Acad Sci USA, 2003, 100(24):13970-13975.
[4] GIBBS M, STANFORD JL, MCINDOE RA, et al. Evidence for a rare prostate cancer-susceptibility locus at chromosome 1p36[J].Am J Hum Genet, 1999, 64(3):776-787.
[5] CHOMA MK, LUMB J, KOZIK P, et al. A genome-wide screen for machinery involved in downregulation of MHC class I by HIV-1Nef[J]. PLoS One, 2015, 10(10):e0140404.
[6] FUJITA T, IGARASHI J, OKAWA ER, et al. CHD5, a tumor suppressor gene deleted from 1p36. 31 in neuroblastomas[J]. J Natl Cancer Institute, 2008, 100(13):940-949.
[7] SHAO JY, WANG HY, HUANG XM, et al. Genome-wide allelotype analysis of sporadic primary nasopharyngeal carcinoma from southern China[J]. Int J Oncol, 2000, 17(6):1267-1275.
[8]黄必军,张林杰,鄢践,等.鼻咽癌染色体1pter-p36. 11杂合性缺失[J].中华病理学杂志, 2001, 30(2):110-113.
[9] SHAO JY, HUANG XM, YU XJ, et al. Loss of heterozygosity and its correlation with clinical outcome and Epstein-Barr virus infection in nasopharyngeal carcinoma[J]. Anticancer Res, 2001, 21(4B):3021-3029.
[10] WANG Y, WEN J, ZHANG W. MIIP, a cytoskeleton regulator that blocks cell migration and invasion, delays mitosis, and suppresses tumorogenesis[J]. Curr Protein Pept Sci, 2011, 12(1):68-73.
[11] WU Y, SONG SW, SUN J, et al. IIp45 inhibits cell migration through inhibition of HDAC6[J]. J Biol Chem, 2010, 285(6):3554-3560.
[12] WANG Y, HU L, JI P, et al. MIIP remodels Rac1-mediated cytoskeleton structure in suppression of endometrial cancer metastasis[J]. J Hematol Oncol, 2016, 9(1):112.
[13] JI P, SMITH SM, WANG Y, et al. Inhibition of gliomagenesis and attenuation of mitotic transition by MIIP[J]. Oncogene, 2010, 29(24):3501-3508.
[14] SELVARAJAH J, ELIA A, CARROLL VA, et al. DNA damage-induced S and G2/M cell cycle arrest requires mTORC2-dependent regulation of Chk1[J]. Oncotarget, 2015, 6(1):427-440.
[15] KASTAN MB, BARTEK J. Cell-cycle checkpoints and cancer[J].Nature, 2004, 432(7015):316-323.
[16]张楠. MIIP对鼻咽癌恶性生物学行为的影响及机制研究[D].南京:南京医科大学, 2017.
[17] WANG X, LIU H, AN Y. Clinical significance of migration and invasion inhibitor protein expression in non-small-cell lung cancer[J].Oncol Lett, 2014, 8(6):2417-2422.
[18] WEN J, FU J, LING Y, et al. MIIP accelerates epidermal growth factor receptor protein turnover and attenuates proliferation in non-small cell lung cancer[J]. Oncotarget, 2016, 7(8):9118-9134.
[19] SONG F, JI P, ZHENG H, et al. Definition of a functional single nucleotide polymorphism in the cell migration inhibitory gene MIIP that affects the risk of breast cancer[J]. Cancer Res, 2010, 70(3):1024-1032.
[20] VAN HEEMST D, MOOIJAART SP, BEEKMAN M, et al. Variation in the human TP53 gene affects old age survival and cancer mortality[J]. Exp Gerontol, 2005, 40(1-2):11-15.
[21] NEUHAUSEN SL, BRUMMEL S, DING YC, et al. Genetic variation in insulin-like growth factor signaling genes and breast cancer risk among BRCA1 and BRCA2 carriers[J]. Breast Cancer Res,2009, 11(5):R76.
[22] WEN J, LIU QW, LUO KJ, et al. MIIP expression predicts outcomes of surgically resected esophageal squamous cell carcinomas[J]. Tumour Biol, 2016, 37(8):10141-10148.
[23] SONG SW, FULLER GN, ZHENG H, et al. Inactivation of the invasion inhibitory gene IIp45 by alternative splicing in gliomas[J]. Cancer Res, 2005, 65(9):3562-3567.
[24] NIU Y, JIN Y, DENG SC, et al. MiRNA-646-mediated reciprocal repression between HIF-1αand MIIP contributes to tumorigenesis of pancreatic cancer[J]. Oncogene, 2018, 37(13):1743-1758.
[25] SUN Y, JI P, CHEN T, et al. MIIP haploinsufficiency induces chromosomal instability and promotes tumor progression in colorectal cancer[J]. J Pathol, 2017, 241(1):67-79.
[26] CHEN T, LI J, XU M, et al. PKCεphosphorylates MIIP and promotes colorectal cancer metastasis through inhibition of RelA deacetylation[J]. Nat Commun, 2017, 8(1):939.
[27]姜素,田文艳,闫晔,等.迁移侵袭抑制蛋白和p21活化激酶1在子宫内膜癌中的表达及其临床意义[J].中华肿瘤杂志, 2018, 40(5):359-364.
[28] ALEKTIAR KM, MCKEE A, LIN O, et al. Is there a difference in outcome between stage I~II endometrial cancer of papillary serous/clear cell and endometrioid FIGO Grade 3 cancer?[J]. Int J Radiat Oncol Biol Phys, 2002, 54(1):79-85.
[29] IRVIN WP, RICE LW, BERKOWITZ RS. Advances in the management of endometrial adenocarcinoma. A review[J]. Reprod Med,2002, 47(3):173-189.
[30] TENG F, TIAN WY, WANG YM, et al. Cancer-associated fibroblasts promote the progression of endometrial cancer via the SDF-1/CXCR4 axis[J]. Hematol Oncol, 2016, 9:8.
[31] BOWSER JL, BLACKBURN MR, Shipley GL, et al. Loss of CD73-mediated actin polymerization promotes endometrial tumor progression[J]. Clin Invest, 2016, 126(1):220-238.
[32] WANG GK, HU L, FULLER GN, et al. An interaction between insulin-like growth factor-binding protein 2(IGFBP2)and integrin alpha5 is essential for IGFBP2-induced cell mobility[J]. Biol Chem,2006, 281(20):14085-14091.
[33] MORGAN MR, BYRON A, HUMPHRIES MJ, et al. Giving off mixed signals—distinct functions of alpha5beta1 and alphavbeta3 integrins in regulating cell behavior[J]. IUBMB Life, 2009, 61(7):731-738.
[34] MIIP通过负性调控EMT抑制前列腺癌的肿瘤生长及侵袭能力[A].王秦豪,严奉奇,茹懿,等.中国生物化学与分子生物学会2016全国学术会议论文集[C]. 2016.
[35]严奉奇,王秦豪,茹懿,等. MIIP对膀胱癌T24细胞增殖和迁移侵袭能力的抑制作用及其机制[J].现代肿瘤医学, 2016, 24(7):1021-1025.
[36]陶光晶.迁移侵袭抑制蛋白在肾癌中的表达及对肾癌细胞增殖、侵袭转移能力的影响研究[D].西安:第四军医大学, 2016.
[2] ZHOU HP, QIAN LX, ZHANG N, et al. MIIP gene expression is associated with radiosensitivity in human nasopharyngeal carcinoma cells[J]. Oncol Lett, 2018, 15(6):9471-9479.
[3] SONG SW, FULLER GN, KHAN A, et al. IIp45, an insulin-like growth factor binding protein 2(IGFBP-2)binding protein, antagonizes IGFBP-2 stimulation of glioma cell invasion[J]. Proc Natl Acad Sci USA, 2003, 100(24):13970-13975.
[4] GIBBS M, STANFORD JL, MCINDOE RA, et al. Evidence for a rare prostate cancer-susceptibility locus at chromosome 1p36[J].Am J Hum Genet, 1999, 64(3):776-787.
[5] CHOMA MK, LUMB J, KOZIK P, et al. A genome-wide screen for machinery involved in downregulation of MHC class I by HIV-1Nef[J]. PLoS One, 2015, 10(10):e0140404.
[6] FUJITA T, IGARASHI J, OKAWA ER, et al. CHD5, a tumor suppressor gene deleted from 1p36. 31 in neuroblastomas[J]. J Natl Cancer Institute, 2008, 100(13):940-949.
[7] SHAO JY, WANG HY, HUANG XM, et al. Genome-wide allelotype analysis of sporadic primary nasopharyngeal carcinoma from southern China[J]. Int J Oncol, 2000, 17(6):1267-1275.
[8]黄必军,张林杰,鄢践,等.鼻咽癌染色体1pter-p36. 11杂合性缺失[J].中华病理学杂志, 2001, 30(2):110-113.
[9] SHAO JY, HUANG XM, YU XJ, et al. Loss of heterozygosity and its correlation with clinical outcome and Epstein-Barr virus infection in nasopharyngeal carcinoma[J]. Anticancer Res, 2001, 21(4B):3021-3029.
[10] WANG Y, WEN J, ZHANG W. MIIP, a cytoskeleton regulator that blocks cell migration and invasion, delays mitosis, and suppresses tumorogenesis[J]. Curr Protein Pept Sci, 2011, 12(1):68-73.
[11] WU Y, SONG SW, SUN J, et al. IIp45 inhibits cell migration through inhibition of HDAC6[J]. J Biol Chem, 2010, 285(6):3554-3560.
[12] WANG Y, HU L, JI P, et al. MIIP remodels Rac1-mediated cytoskeleton structure in suppression of endometrial cancer metastasis[J]. J Hematol Oncol, 2016, 9(1):112.
[13] JI P, SMITH SM, WANG Y, et al. Inhibition of gliomagenesis and attenuation of mitotic transition by MIIP[J]. Oncogene, 2010, 29(24):3501-3508.
[14] SELVARAJAH J, ELIA A, CARROLL VA, et al. DNA damage-induced S and G2/M cell cycle arrest requires mTORC2-dependent regulation of Chk1[J]. Oncotarget, 2015, 6(1):427-440.
[15] KASTAN MB, BARTEK J. Cell-cycle checkpoints and cancer[J].Nature, 2004, 432(7015):316-323.
[16]张楠. MIIP对鼻咽癌恶性生物学行为的影响及机制研究[D].南京:南京医科大学, 2017.
[17] WANG X, LIU H, AN Y. Clinical significance of migration and invasion inhibitor protein expression in non-small-cell lung cancer[J].Oncol Lett, 2014, 8(6):2417-2422.
[18] WEN J, FU J, LING Y, et al. MIIP accelerates epidermal growth factor receptor protein turnover and attenuates proliferation in non-small cell lung cancer[J]. Oncotarget, 2016, 7(8):9118-9134.
[19] SONG F, JI P, ZHENG H, et al. Definition of a functional single nucleotide polymorphism in the cell migration inhibitory gene MIIP that affects the risk of breast cancer[J]. Cancer Res, 2010, 70(3):1024-1032.
[20] VAN HEEMST D, MOOIJAART SP, BEEKMAN M, et al. Variation in the human TP53 gene affects old age survival and cancer mortality[J]. Exp Gerontol, 2005, 40(1-2):11-15.
[21] NEUHAUSEN SL, BRUMMEL S, DING YC, et al. Genetic variation in insulin-like growth factor signaling genes and breast cancer risk among BRCA1 and BRCA2 carriers[J]. Breast Cancer Res,2009, 11(5):R76.
[22] WEN J, LIU QW, LUO KJ, et al. MIIP expression predicts outcomes of surgically resected esophageal squamous cell carcinomas[J]. Tumour Biol, 2016, 37(8):10141-10148.
[23] SONG SW, FULLER GN, ZHENG H, et al. Inactivation of the invasion inhibitory gene IIp45 by alternative splicing in gliomas[J]. Cancer Res, 2005, 65(9):3562-3567.
[24] NIU Y, JIN Y, DENG SC, et al. MiRNA-646-mediated reciprocal repression between HIF-1αand MIIP contributes to tumorigenesis of pancreatic cancer[J]. Oncogene, 2018, 37(13):1743-1758.
[25] SUN Y, JI P, CHEN T, et al. MIIP haploinsufficiency induces chromosomal instability and promotes tumor progression in colorectal cancer[J]. J Pathol, 2017, 241(1):67-79.
[26] CHEN T, LI J, XU M, et al. PKCεphosphorylates MIIP and promotes colorectal cancer metastasis through inhibition of RelA deacetylation[J]. Nat Commun, 2017, 8(1):939.
[27]姜素,田文艳,闫晔,等.迁移侵袭抑制蛋白和p21活化激酶1在子宫内膜癌中的表达及其临床意义[J].中华肿瘤杂志, 2018, 40(5):359-364.
[28] ALEKTIAR KM, MCKEE A, LIN O, et al. Is there a difference in outcome between stage I~II endometrial cancer of papillary serous/clear cell and endometrioid FIGO Grade 3 cancer?[J]. Int J Radiat Oncol Biol Phys, 2002, 54(1):79-85.
[29] IRVIN WP, RICE LW, BERKOWITZ RS. Advances in the management of endometrial adenocarcinoma. A review[J]. Reprod Med,2002, 47(3):173-189.
[30] TENG F, TIAN WY, WANG YM, et al. Cancer-associated fibroblasts promote the progression of endometrial cancer via the SDF-1/CXCR4 axis[J]. Hematol Oncol, 2016, 9:8.
[31] BOWSER JL, BLACKBURN MR, Shipley GL, et al. Loss of CD73-mediated actin polymerization promotes endometrial tumor progression[J]. Clin Invest, 2016, 126(1):220-238.
[32] WANG GK, HU L, FULLER GN, et al. An interaction between insulin-like growth factor-binding protein 2(IGFBP2)and integrin alpha5 is essential for IGFBP2-induced cell mobility[J]. Biol Chem,2006, 281(20):14085-14091.
[33] MORGAN MR, BYRON A, HUMPHRIES MJ, et al. Giving off mixed signals—distinct functions of alpha5beta1 and alphavbeta3 integrins in regulating cell behavior[J]. IUBMB Life, 2009, 61(7):731-738.
[34] MIIP通过负性调控EMT抑制前列腺癌的肿瘤生长及侵袭能力[A].王秦豪,严奉奇,茹懿,等.中国生物化学与分子生物学会2016全国学术会议论文集[C]. 2016.
[35]严奉奇,王秦豪,茹懿,等. MIIP对膀胱癌T24细胞增殖和迁移侵袭能力的抑制作用及其机制[J].现代肿瘤医学, 2016, 24(7):1021-1025.
[36]陶光晶.迁移侵袭抑制蛋白在肾癌中的表达及对肾癌细胞增殖、侵袭转移能力的影响研究[D].西安:第四军医大学, 2016.