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IL-6和SAA在原发性肾病综合征复发患儿合并感染中的诊断价值
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  • 英文篇名:DIAGNOSTIC VALUE OF IL-6 AND SAA IN RELAPSE OF PRIMARY NEPHROTIC SYNDROME COMBINED WITH INFECTION IN CHILDREN
  • 作者:郑志方 ; 陈国利 ; 孙鹏
  • 英文作者:ZHENG Zhi-fang;CHEN Guo-li;SUN Peng;the Affiliated Hospital of Chengde Medical College;
  • 关键词:白介素6 ; 血清淀粉样蛋白A ; 原发性肾病综合征 ; 复发
  • 英文关键词:Interleukin 6;;Serum amyloid protein A;;Primary nephrotic syndrome;;Relapse
  • 中文刊名:CDYX
  • 英文刊名:Journal of Chengde Medical College
  • 机构:承德医学院附属医院;
  • 出版日期:2019-04-01
  • 出版单位:承德医学院学报
  • 年:2019
  • 期:v.36;No.143
  • 语种:中文;
  • 页:CDYX201902008
  • 页数:3
  • CN:02
  • ISSN:13-1154/R
  • 分类号:26-28
摘要
目的:探讨白介素6(IL-6)和血清淀粉样蛋白A(SAA)对儿童原发性肾病综合征(PNS)复发合并感染的诊断价值。方法:78例PNS复发患儿分为三组,A组:PNS合并细菌感染42例,B组:PNS合并病毒感染24例,C组:非感染PNS复发患儿l2例。分别检测三组患儿的IL-6、SAA水平,并建立受试者工作曲线(ROC)评价IL-6和SAA对PNS合并细菌感染的诊断价值。结果:A组患儿IL-6、SAA阳性率(85.71%、71.43%)明显高于B组(0.00%、20.83%)和C组(16.67%、33.33%),差异有统计学意义(P<0.05)。IL-6的ROC曲线下面积(AUC)为0.899,SAA的AUC为0.56。IL-6截断点为10.71时,诊断PNS合并细菌感染的敏感度及特异性分别为85.7%和91.7%,Youden指数为0.774,阳性及阴性似然比分别为10.33和0.16。结论:检测SAA和IL-6可用于区分PNS合并细菌感染与PNS合并病毒感染和非感染;其中IL-6在PNS合并细菌感染时有较高的辅助诊断价值。
        Objective: To investigate the diagnostic value of interleukin 6(IL-6) and serum amyloid protein A(SAA in relapse of primary nephrotic syndrome combined with infection in children. Methods: 78 children with relapse of primary nephrotic syndrome were divided into 3 groups: group A, 42 children with relapse of primary nephrotic syndrome combined bacterial infection; group B, 24 children with relapse of primary nephrotic syndrome combined viral infection; group C,12 children with relapse of primary nephrotic syndrome with non infection. The serum IL-6 level and SAA of children in 3 groups were respectively detected, and ROC curve were established to evaluate the diagnostic value of IL-6 and SAA in relapse of primary nephrotic syndrome combined with bacterial infection. Results: The positive rate of IL-6 and SAA(85.71%,71.43%) of children in group A were significantly higher than group B(0.00%, 20.83%) and group C(16.67%, 33.33%, P<0.05).The AUC of IL-6 and SAA was respectively 0.899 and 0.56. When the cutoff point of IL-6 was 10.71, the sensitivity,specificity, Youden index, positive likelihood ratio and negative likelihood ratio of IL-6 in diagnosing primary nephrotic syndrome combined with bacterial infection were 85.7%, 91.7%, 0.774, 10.33 and 0.16. Conclusions: Detection of SAA and IL-6 can be used to distinguish primary nephrotic syndrome combined bacterial infection from with viral infection and non infection. Moreover, IL-6 has a higher diagnostic value in primary nephrotic syndrome combined with bacterial infection.
引文
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