白首乌的研究进展
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摘要
白首乌是传统补益类中药材,具有补益肝肾、养血益精、强筋壮骨、乌须生发、抗衰老之功效,被历代医家奉为延年防老的珍品。近年来,国内学者对不同品种的白首乌进行了药理活性及物质基础的相关研究。现将白首乌近年来的研究新进展进行综述,通过对不同品种白首乌C21甾体总苷、苯酮类化合物结构和含量的差异,不同品种白首乌多糖类成分和营养物质含量的差异,以及不同化学成分的药理活性进行系统归纳,为进一步合理利用白首乌提供科学依据。
Cynanchi Bungei Radix is a traditional Chinese herbal medicine which has been used as a tonic agent owing to its primary abilities of tonifying liver and kidney, nourishing blood and replenishing semen, strengthening tendons and bones, promoting hair growth, and prolonging life. Pharmacological effects and material basis of Cynanchi Bungei Radix have been extensively investigated.This paper reviews the recent research progress of Cynanchi Bungei Radix based on the difference in the pharmacological effects and content of different chemical constituents in different species of Cynanchi Bungei Radix. It provides a scientific basis for further rational application of the medicinal value of different varieties of Cynanchi Bungei Radix.
Cynanchi Bungei Radix is a traditional Chinese herbal medicine which has been used as a tonic agent owing to its primary abilities of tonifying liver and kidney, nourishing blood and replenishing semen, strengthening tendons and bones, promoting hair growth, and prolonging life. Pharmacological effects and material basis of Cynanchi Bungei Radix have been extensively investigated.This paper reviews the recent research progress of Cynanchi Bungei Radix based on the difference in the pharmacological effects and content of different chemical constituents in different species of Cynanchi Bungei Radix. It provides a scientific basis for further rational application of the medicinal value of different varieties of Cynanchi Bungei Radix.
引文
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[29]陈蒋丽,张玲,李艳芳,等.白首乌苷B抗结肠癌作用的研究[J].中华中医药学刊,2015(10):2370-2374.
[30]吕伟红,张爱香,徐姗,等.江苏地产白首乌总苷对大鼠肝纤维化作用的研究[J].中国中药杂志,2009,34(19):2508-2511.
[31]王冬艳,华欣,叶记林,等.江苏地产白首乌C21甾体苷对高血脂大鼠血脂调节和肝脏保护作用研究[J].安徽医药,2015(8):1454-1457.
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[33]Qian X,Li B,Li P,et al.C21 Steroidal glycosides from Cynanchum auriculatum and their neuroprotective effects against H2O2-induced damage in PC12 cells[J].Phytochemistry,2017,140(2):1-15.
[34]惠勇.白首乌C21甾苷对慢性心力衰竭大鼠心肌的保护作用[J].中国药物经济学,2016,10(2):12-15.
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[36]Qin J J,Chen X,Lin Z M,et al.C21-steroidal glycosides and sesquiterpenes from the roots of Cynanchum bungei and their inhibitory activities against the proliferation of B and T lymphocytes[J].Fitoterapia,2018,124(6):193-199.
[37]徐凌川,张华,许昌盛.白首乌化学成分与药理现代研究述评[J].中华中医药学刊,2003,21(11):1893-1895.
[38]林爱群.泰山白首乌化学成分的提取、分离与鉴定[D].济南:山东中医药大学,2005.
[39]孙得峰.泰山白首乌化学成分及生物活性研究[D].济南:济南大学,2015.
[40]徐凌川,马凤英,郭素,等.泰山白首乌药材质量标准初步研究[J].食品与药品,2006,8(1):41-43.
[41]侯彩婷.泰山白首乌新品种生物学特性研究及其主要活性成分的含量测定[D].济南:山东中医药大学,2013.
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[44]吴红雁,陈磊,卞庆亚,等.一测多评法测定白首乌中苯乙酮成分的含量[J].中药材,2015,38(11):2339-2341.
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[2]陈东伟,胡明哲,李克明,等.泰山白首乌的药理作用和临床应用[J].临床医药文献电子杂志,2017,4(54):10666-10667.
[3]张宁,闫滨,徐星航,等.不同来源白首乌r DNAITS序列分析[J].中国中药杂志,2010,35(12):1537-1540.
[4]陈艳.民族药隔山消的化学成分的研究[D].贵阳:贵州大学,2008.
[5]赵家文.泰山白首乌中C21甾体化合物的分离鉴定及其抑制Hedgehog信号通路活性的研究[D].杭州:浙江省医学科学院,2017.
[6]印敏,冯煦,董云发,等.白首乌化学成分与药理活性研究进展[J].中国野生植物资源,2004,23(2):8-11.
[7]龚树生.白首乌的系统研究[J].中华中医药杂志,1987,2(2):23-25.
[8]宋康,张锋,杜方岭.不同提取工艺下白首乌C21甾苷含量研究[J].中国食物与营养,2010,15(10):46-49.
[9]郭娜,李晓鹏,许枬,等.耳叶牛皮消中C21甾类化学成分的分离与鉴定[J].沈阳药科大学学报,2016,(1):28-33.
[10]费洪荣,梁天娇,王玲爱,等.白首乌中的C21甾体苷的提取及纯化工艺研究[J].时珍国医国药,2015,26(5):1091-1093.
[11]陈纪军,张壮鑫,周俊.白首乌的化学成分[J].植物分类与资源学报,1989,11(3):358-360.
[12]费洪荣.白首乌中告达庭的制备及其抗肿瘤活性研究[D].济南:山东中医药大学,2015.
[13]Peng Y R,Ding Y F,Wei Y J,et al.Caudatin-2,6-dideoxy-3-O-methy-β-D-cymaropyranoside 1 induced apoptosis through caspase 3-dependent pathway in human hepatoma cell line SMMC7721[J].Phytother Res Ptr,2011,25(5):631-637.
[14]龚淑玲,白燕萍.白首乌化学成分研究[J].海峡药学,2009,21(11):84-89.
[15]宋俊梅,陶冠军,汤坚,等.白首乌中C21甾甙元的分离与结构鉴定[J].食品与生物技术学报,2002,21(2):176-178.
[16]Zhang R S,Ye Y P,Shen Y M,et al.Two new cytotoxic C-21 steroidal glycosides from the root of Cynanchum auriculatum[J].Tetrahedron,2000,56(24):3875-3879.
[17]张如松,叶益萍,刘雪莉.白首乌甾体总苷的体外抗肿瘤作用[J].中草药,2000,31(8):599-601.
[18]曾郁敏,顾立刚,王玥琦.白首乌甙体外抗肿瘤作用的实验研究[J].中国中医药信息杂志,2000,7(4):30-32.
[19]Lee D U,Shin U S,Huh K.Inhibitory effects of gagaminine,a steroidal alkaloid from Cynanchum wilfordi,on lipid peroxidation and aldehyde oxidase activity[J].Planta Medica,1996,62(6):485-487.
[20]谢凯强.隔山消化学成分及生物活性研究[D].贵阳:贵州大学,2017.
[21]谢凯强,苑春茂,蹇军友,等.隔山牛皮消、耳叶牛皮消和戟叶牛皮消中四个C21-甾体苷元含量比较研究[J].天然产物研究与开发,2018,30(2):261-267.
[22]Gu X J,Yao N,Qian S H,et al.Four new C21 steroidal glycosides from the roots of Cynanchum auriculatum[J].Helv Chim Acta,2010,92(1):88-97.
[23]Peng Y,Li Y,Wang D,et al.Determination of caudatin-2,6-dideoxy-3-O-methy-beta-D-cymaropyranosi de in rat plasma using liquid chromatography-tandem mass spectrometry[J].Biomed Chromatogr BMC,2010,22(6):575-580.
[24]Li Y,Zhang J,Gu X,et al.Two new cytotoxic pregnane glycosides from Cynanchum auriculatum[J].Planta Med,2008,74(5):551-554.
[25]赵鑫.白首乌C21甾总苷的化学降解及降解产物抗肿瘤活性研究[D].南京:南京中医药大学,2011.
[26]陈亚,徐晓燕.白首乌的药理作用及其开发利用[J].时珍国医国药,2013,24(4):936-937.
[27]贾翎,顾立刚,曾郁敏,等.白首乌苷对二乙基亚硝胺诱发实验性肝癌大鼠细胞因子产生的影响[J].中华中医药杂志,2012(10):2720-2722.
[28]Dong J,Peng X,Li L,et al.C21 steroidal glycosides with cytotoxic activities from Cynanchum otophyllum[J].Bioorg Med Chem Lett,2018(20):1520-1524.
[29]陈蒋丽,张玲,李艳芳,等.白首乌苷B抗结肠癌作用的研究[J].中华中医药学刊,2015(10):2370-2374.
[30]吕伟红,张爱香,徐姗,等.江苏地产白首乌总苷对大鼠肝纤维化作用的研究[J].中国中药杂志,2009,34(19):2508-2511.
[31]王冬艳,华欣,叶记林,等.江苏地产白首乌C21甾体苷对高血脂大鼠血脂调节和肝脏保护作用研究[J].安徽医药,2015(8):1454-1457.
[32]Wu Z Z,Wang Y Y,Meng X,et al.Total C-21 steroidal glycosides,isolated from the root tuber of Cynanchum auriculatum Royle ex Wight,attenuate hydrogen peroxide-induced oxidative injury and inflammation in L02 cells[J].Int J Mol Med,2018,42(9):3157-3170.
[33]Qian X,Li B,Li P,et al.C21 Steroidal glycosides from Cynanchum auriculatum and their neuroprotective effects against H2O2-induced damage in PC12 cells[J].Phytochemistry,2017,140(2):1-15.
[34]惠勇.白首乌C21甾苷对慢性心力衰竭大鼠心肌的保护作用[J].中国药物经济学,2016,10(2):12-15.
[35]惠勇,徐雷.白首乌C21甾苷对大鼠心肌缺血再灌注损伤的保护作用[J].中国食物与营养,2015,21(6):68-71.
[36]Qin J J,Chen X,Lin Z M,et al.C21-steroidal glycosides and sesquiterpenes from the roots of Cynanchum bungei and their inhibitory activities against the proliferation of B and T lymphocytes[J].Fitoterapia,2018,124(6):193-199.
[37]徐凌川,张华,许昌盛.白首乌化学成分与药理现代研究述评[J].中华中医药学刊,2003,21(11):1893-1895.
[38]林爱群.泰山白首乌化学成分的提取、分离与鉴定[D].济南:山东中医药大学,2005.
[39]孙得峰.泰山白首乌化学成分及生物活性研究[D].济南:济南大学,2015.
[40]徐凌川,马凤英,郭素,等.泰山白首乌药材质量标准初步研究[J].食品与药品,2006,8(1):41-43.
[41]侯彩婷.泰山白首乌新品种生物学特性研究及其主要活性成分的含量测定[D].济南:山东中医药大学,2013.
[42]陈炳阳,岳荣彩,刘芳,等.耳叶牛皮消中的苯乙酮类化合物及其抗氧化活性研究[J].药学实践杂志,2013,31(5):351-354.
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