外泌体在白血病细胞增殖中的作用
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摘要
<正>外泌体又被称为胞外体,是活细胞分泌在体液中的一种纳米级的、膜包被小泡,直径约为30~120 nm,表面富含胆固醇、神经鞘磷脂、神经酰胺等脂类物质,携带亲本细胞来源的蛋白质、mRNA、microRNA、DNA等分子信息,是细胞间信息交流与的物质传递的载体~([1~3])。外泌体来源于活细胞胞质内、晚期内吞体的膜性囊泡,其融合为多囊体后与细胞质膜融合释放到细胞外~([4])。外泌体广泛存在于血液、唾液、尿液、脑脊液以及胸水、腹水等体液中,不
引文
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3 Simons M,Raposo G.Exosomes-vesicular carriers for intercellular communication[J].Curr Opin Cell Biol,2009;21(4):575-81.
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5 Lsser C,Alikhani VS,Ekstr9m K,et al.Human saliva,plasma and breast milk exosomes contain RNA:uptake by macrophages[J].J Transl Med,2011;9(1):1
6 Poliakov A,Spilman M,Dokland T,et al.Structural heterogeneity and protein composition of exosome‐like vesicles(prostasomes)in human semen[J].Prostate,2009;69(2):159-67.
7 Viola S,Traer E,Huan J,et al.Alterations in acute myeloid leukaemia bone marrow stromal cell exosome content coincide with gains in tyrosine kinase inhibitor resistance[J].Br J Haematol,2016;172(6):983-6。
8 Hornick NI,Doron B,Abdelhamed S,et al.AML suppresses hematopoiesis by releasing exosomes that contain microRNAs targeting c-MYB[J].Sci Signal,2016;9(444):ra88.
9 Katsuda T,Kosaka N,Ochiya T.The roles of extracellular vesicles in cancer biology:toward the development of novel cancer biomarkers[J].Proteomics,2014;14(4-5):412-25.
10 Hong CS,Muller L,Whiteside TL,et al.Plasma exosomes as markers of therapeutic response in patients with acute myeloid leukemia[J].Front Immunol,2014;5:160.
11 Corrado C,Flugy AM,Taverna S,et al.Carboxyamidotriazole-orotate inhibits the growth of imatinib-resistant chronic myeloid leukaemia cells and modulates exosomes-stimulated angiogenesis[J].PLo S One,2012;7(8):e42310.
12 Feng DQ,Huang B,Li J,et al.Selective miRNA expression profile in chronic myeloid leukemia K562 cell-derived exosomes[J].Asian Pac JCancer Prev,2013;14(12):7501-8.
13 Huan J,Hornick NI,Shurtleff M J,et al.RNA trafficking by acute myelogenous leukemia exosomes[J].Cancer Res,2013;73(2):918-29.
14 Hazan-Halevy I,Rosenblum D,Weinstein S,et al.Cell-specific uptake of mantle cell lymphoma-derived exosomes by malignant and non-malignant B-lymphocytes[J].Cancer Lett,2015;364(1):59-69.
15 Patel SJ,Darie CC,Clarkson BD.Exosome mediated growth effect on the non-growing pre-B acute lymphoblastic leukemia cells at low starting cell density[J].Am J Transl Res,2016;8(9):3614-29.
16 Yeh YY,Ozer HG,Lehman AM,et al.Characterization of CLL exosomes reveals a distinct microRNA signature and enhanced secretion by activation of BCR signaling[J].Blood,2015;125(21):3297-305.
17 Hornick NI,Huan J,Doron B,et al.Serum exosome MicroRNA as a minimally-invasive early biomarker of AML[J].Sci Rep,2015;5:11295.
18 Corrado C,Raimondo S,Saieva L,et al.Exosome-mediated crosstalk between chronic myelogenous leukemia cells and human bone marrow stromal cells triggers an interleukin 8-dependent survival of leukemia cells[J].Cancer Lett,2014;348(1):71-6.
19 Huan J,Hornick NI,Goloviznina NA,et al.Coordinate regulation of residual bone marrow function by paracrine trafficking of AML exosomes[J].Leukemia,2015;29(12):2285-95.
20 Jaworski E,Narayanan A,van Duyne R,et al.Human T-lymphotropic virus type 1-infected cells secrete exosomes that contain Tax protein[J].JBiol Chem,2014;289(32):22284-305.
21 Caivano A,Laurenzana I,De Luca L,et al.High serum levels of extracellular vesicles expressing malignancy-related markers are released in patients with various types of hematological neoplastic disorders[J].Tumour Biol,2015;36(12):9739-52.