胎儿宫内生长受限动物模型的研究
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摘要
胎儿宫内生长受限(IUGR)是围产期胎儿发病率和死亡率的主要原因之一。胎儿宫内生长发育与母体及宫内环境等多种因素都密切相关,且IUGR的病因和发病机制未完全揭示。因此,建立与人类临床病理特征相似的IUGR动物模型是研究其发病机制及寻求有效治疗方法的有效途径。通过介绍啮齿类、灵长类、家养类等不同动物的IUGR模型,并综述自然选择法、子宫动脉结扎法、营养限饲法等IUGR动物模型的构建方法,为选择复制IUGR的动物以及复制模型的方法提供新的依据。
IUGR is a serious complication in obstetrics and important cause of perinatal mortality. Fetal growth and development are closely related to many factors,such as maternal and intrauterine environment. The etiological factors and mechanism of IUGR is not fully revealed. Therefore,establishing IUGR animal models is an effective way to study the pathological characteristics and treatment methods of human IUGR. In this article,the authors review several kinds of experimental animal models of IUGR,including rodents,primate,domesticated animals,and compare the natural selection,uterine artery ligation,nutritional feed restriction for building IUGR models. Further study of these mechanisms could support evidence for choosing the experimental animals and the modeling methods of IUGR.
IUGR is a serious complication in obstetrics and important cause of perinatal mortality. Fetal growth and development are closely related to many factors,such as maternal and intrauterine environment. The etiological factors and mechanism of IUGR is not fully revealed. Therefore,establishing IUGR animal models is an effective way to study the pathological characteristics and treatment methods of human IUGR. In this article,the authors review several kinds of experimental animal models of IUGR,including rodents,primate,domesticated animals,and compare the natural selection,uterine artery ligation,nutritional feed restriction for building IUGR models. Further study of these mechanisms could support evidence for choosing the experimental animals and the modeling methods of IUGR.
引文
[1]DAVIS M A,MACKO A R,STEYN L V,et al.Intrauterine growth restriction[J].Nutrients,2015,7(1):500-516.
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[3]HUNTER D S,HAZEL S J,KIND K L,et al.Programming the brain:Common outcomes and gaps in knowledge from animal studies of IUGR.[J].Physiol Behav,2016,164(Part A):233-248.
[4]孙玲伟.RP-Arg和NCG对妊娠期营养限饲湖羊胎儿和胎盘发育的影响[D].南京:南京农业大学,2017.
[5]MALISZEWSKI-HALL A M,ALEXANDER M,,et al.Differentialeffects of intrauterine growth restriction on the regional neurochemical profile of the developing rat brain[J].Neurochem Res,2017,42(1):133-140.
[6]苏畅.孕晚期内毒素暴露对不同性别子代体重和糖脂代谢的影响[D].合肥:安徽医科大学,2017.
[7]LOPEZ-TELLO J,ARIAS-ALVAREZ M,JIMENEZ-MARTINEZ M A,et al.Competition for materno-fetal resource partitioning in a rabbit model of undernourished pregnancy[J].Plos One,2017,12(1):e0169194.
[8]LI C,SHU Z J,LEE S,et al.Effects of maternal nutrient restriction,intrauterine growth restriction,and glucocorticoid exposure on phosphoenolpyruvate carboxykinase-1 expression in fetal baboon hepatocytes in vitro[J].J Med Primatol,2013,42(4):211-219.
[9]LI C,RAMAHI E,NIJLAND M J,et al.Up-regulation of the fetal baboon hypothalamo-pituitary-adrenal axis in intrauterine growth restriction:coincidence with hypothalamic glucocorticoid receptor insensitivity and leptin receptor down-regulation[J].Endocrinology,2013,154(7):2365-2373.
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[11]SUN L W,GUO Y X,FAN Y X,et al.Metabolic profiling of stages of healthy pregnancy in Hu sheep using nuclear magnetic resonance(NMR)[J].Theriogenology,2017,92:121.
[12]SUN L W,ZHANG H,FAN Y X,et al.Metabolomic profiling in umbilical venous plasma reveals effects of dietary rumen-protected arginine or N-carbamylglutamate supplementation in nutrient-restricted Hu sheep during pregnancy.[J].Reprod Domest Anim.2017,52(3):376-388.
[13]ZHANG H,SUN L W,WANG Z Y,et al.N-carbamylglutamate and l-arginine improved maternal and placental development in underfed ewes[J].Reproduction,2016,151(6):623-635.
[14]SUN L W,ZHANG H,WANG Z Y,et al.Dietary rumen-protected arginine and N-carbamylglutamate supplementation enhances fetal growth in underfed ewes[J].Reprod Fertil Dev,2018,30(8):1116-1127.
[15]金慧慧,赵永聚.胎儿宫内发育迟缓(IUGR)动物模型研究进展[J].中国比较医学杂志,2013,23(10):71-75.
[16]高琳琳,王军,李子英,等.不同方法制备大鼠宫内发育迟缓模型的比较[J].中国比较医学杂志,2018,28(1):1-7.
[17]RUFF C A,FAULKNER S D,RUMAJOGEE P,et al.The extent of intrauterine growth restriction determines the severity of cerebral injury and neurobehavioural deficits in rodents[J].Plos One,2017,12(9):e0184653.
[18]谭星宇,何权瀛.母体妊娠期营养不良对SD仔鼠肺功能的影响[J].中国比较医学杂志,2006,16(7):398-401.
[19]周根来,陈才勇,王恬.胎儿宫内发育迟缓的实验动物模型[J].中国比较医学杂志,2003,13(2):117-120.
[20]增振山,王瑜,刘福英.动物实验机构与动物福利关系研究[J].医学动物防制,2013(1):35-39.
[2]ADITYA I,TAT V,SAWANA A,et al.Use of Doppler velocimetry in diagnosis and prognosis of intrauterine growth restriction(IUGR):a review[J].J Neonatal Perinatal Med,2016,9(2):117-126.
[3]HUNTER D S,HAZEL S J,KIND K L,et al.Programming the brain:Common outcomes and gaps in knowledge from animal studies of IUGR.[J].Physiol Behav,2016,164(Part A):233-248.
[4]孙玲伟.RP-Arg和NCG对妊娠期营养限饲湖羊胎儿和胎盘发育的影响[D].南京:南京农业大学,2017.
[5]MALISZEWSKI-HALL A M,ALEXANDER M,,et al.Differentialeffects of intrauterine growth restriction on the regional neurochemical profile of the developing rat brain[J].Neurochem Res,2017,42(1):133-140.
[6]苏畅.孕晚期内毒素暴露对不同性别子代体重和糖脂代谢的影响[D].合肥:安徽医科大学,2017.
[7]LOPEZ-TELLO J,ARIAS-ALVAREZ M,JIMENEZ-MARTINEZ M A,et al.Competition for materno-fetal resource partitioning in a rabbit model of undernourished pregnancy[J].Plos One,2017,12(1):e0169194.
[8]LI C,SHU Z J,LEE S,et al.Effects of maternal nutrient restriction,intrauterine growth restriction,and glucocorticoid exposure on phosphoenolpyruvate carboxykinase-1 expression in fetal baboon hepatocytes in vitro[J].J Med Primatol,2013,42(4):211-219.
[9]LI C,RAMAHI E,NIJLAND M J,et al.Up-regulation of the fetal baboon hypothalamo-pituitary-adrenal axis in intrauterine growth restriction:coincidence with hypothalamic glucocorticoid receptor insensitivity and leptin receptor down-regulation[J].Endocrinology,2013,154(7):2365-2373.
[10]FERENC K,,SKRZYPEK T,et al.Structure and function of enterocyte in intrauterine growth retarded pig neonates[J].Dis Markers,2017,2017:1-9.
[11]SUN L W,GUO Y X,FAN Y X,et al.Metabolic profiling of stages of healthy pregnancy in Hu sheep using nuclear magnetic resonance(NMR)[J].Theriogenology,2017,92:121.
[12]SUN L W,ZHANG H,FAN Y X,et al.Metabolomic profiling in umbilical venous plasma reveals effects of dietary rumen-protected arginine or N-carbamylglutamate supplementation in nutrient-restricted Hu sheep during pregnancy.[J].Reprod Domest Anim.2017,52(3):376-388.
[13]ZHANG H,SUN L W,WANG Z Y,et al.N-carbamylglutamate and l-arginine improved maternal and placental development in underfed ewes[J].Reproduction,2016,151(6):623-635.
[14]SUN L W,ZHANG H,WANG Z Y,et al.Dietary rumen-protected arginine and N-carbamylglutamate supplementation enhances fetal growth in underfed ewes[J].Reprod Fertil Dev,2018,30(8):1116-1127.
[15]金慧慧,赵永聚.胎儿宫内发育迟缓(IUGR)动物模型研究进展[J].中国比较医学杂志,2013,23(10):71-75.
[16]高琳琳,王军,李子英,等.不同方法制备大鼠宫内发育迟缓模型的比较[J].中国比较医学杂志,2018,28(1):1-7.
[17]RUFF C A,FAULKNER S D,RUMAJOGEE P,et al.The extent of intrauterine growth restriction determines the severity of cerebral injury and neurobehavioural deficits in rodents[J].Plos One,2017,12(9):e0184653.
[18]谭星宇,何权瀛.母体妊娠期营养不良对SD仔鼠肺功能的影响[J].中国比较医学杂志,2006,16(7):398-401.
[19]周根来,陈才勇,王恬.胎儿宫内发育迟缓的实验动物模型[J].中国比较医学杂志,2003,13(2):117-120.
[20]增振山,王瑜,刘福英.动物实验机构与动物福利关系研究[J].医学动物防制,2013(1):35-39.