基于多指标权重分析和正交设计法优选复方必清颗粒的提取工艺
|
摘要
目的确定指标权重,优选复方必清颗粒提取工艺,为其工业化生产提供参考。方法以薯蓣皂苷元、秋水仙碱、槲皮素含量和出膏率为评价指标,采用层次分析法(analytichierarchyprocess,AHP)、CRITIC法及AHP-CRITIC混合加权法确定各指标权重系数,结合正交试验结果优化复方必清颗粒提取工艺参数。结果 AHP-CRITIC混合加权法较AHP法和CRITIC法科学、合理、稳定,按照其确定的权重系数进行综合评价,确定复方必清颗粒的最佳提取工艺条件:加8倍量70%乙醇,提取2次,每次1.0 h。结论 AHP-CRITIC混合加权法确定的权重系数客观、真实,可以反映复方必清颗粒配伍信息,优选得到的工艺稳定可行,重复性好,可用于工业化生产。
OBJECTIVE To provide a reference for the industrial production of the extraction process of Compound Biqing granules by exploring the optional extraction process parameters based on determing the index weight. METHODS With the extraction capacity of diosgenin, colchicine, quercetin and ratio of extraction as comprehensive evaluation indexes, the weighting coefficient in four synthetic evaluation indexes was determined by analytic hierarchy process(AHP), criteria importance through intercriteria correlation(CRITIC) method, and mixed weighted AHP-CRITIC. And ethanol-extracting process was optimized by orthogonal test. RESULTS Mixed weighted AHP-CRITIC was more scientific, reasonable, and stable than AHP and CRITIC. The optimal process parameters were confirmed to be decocting for twice with 1.0 h in each by eight times the amount of 70% ethanol, according to the weight coefficient determined by comprehensive evaluation. CONCLUSION The weight coefficient determined by mixed weighted AHP-CRITIC is objective, real and can reflect the compound compatibility information. The optimized technology is stable, feasible, and suitable for standardized production of Compound Biqing granules.
OBJECTIVE To provide a reference for the industrial production of the extraction process of Compound Biqing granules by exploring the optional extraction process parameters based on determing the index weight. METHODS With the extraction capacity of diosgenin, colchicine, quercetin and ratio of extraction as comprehensive evaluation indexes, the weighting coefficient in four synthetic evaluation indexes was determined by analytic hierarchy process(AHP), criteria importance through intercriteria correlation(CRITIC) method, and mixed weighted AHP-CRITIC. And ethanol-extracting process was optimized by orthogonal test. RESULTS Mixed weighted AHP-CRITIC was more scientific, reasonable, and stable than AHP and CRITIC. The optimal process parameters were confirmed to be decocting for twice with 1.0 h in each by eight times the amount of 70% ethanol, according to the weight coefficient determined by comprehensive evaluation. CONCLUSION The weight coefficient determined by mixed weighted AHP-CRITIC is objective, real and can reflect the compound compatibility information. The optimized technology is stable, feasible, and suitable for standardized production of Compound Biqing granules.
引文
[1]LU Y N,CHEN D S,FU L,et al.Study on the pharmacological action of the extracts from Smilax china.L.on promoting blood circulation to remove blood stasis[J].JChina Pharm Univ(中国药科大学学报),2001,32(6):448-450.
[2]LI Z J,DAW U T,XIAO W,et al.AIBAI·Silafu2,3Antifungi of Euphorbia humifusa extract and its effect on ultrastructure of dermatophytes[J].Chin Tradit Herb Drugs(中草药),2009,40(5):758-763.
[3]LIU Y,LI Z C,CHEN J B.Therapeutic efficacy of small doses of colchicine combined with glucocorticoid for acute gouty arthritis[J].Med J Chin PLA(解放军医学杂志),2015,40(8):652-655.
[4]REN A N,LU A Q,TIAN Y Z,et al.AHP application to study of weighted coefficient on multicriteria optimization of extraction technology about Chinese traditional compound drugs[J].China J Chin Mater Med(中国中药杂志),2008,33(4):372-375.
[5]XIA P F,MA X,WANG J,et al.Evaluating the quality of Gentiana officinalis H.Smith with fuzzy matter-element model based on variation coefficient weight[J].Chin J Mod Appl Pharm(中国现代应用药学),2018,35(4):461-466.
[6]YANG M,ZHOU X,XIE R F,et al.Application of analytic hierarchy process(AHP)combined with CRITIC to studying weighted coefficient of multiple criteria for optimization of extraction technology of Compound Zishenqing granules[J].Pharm Care Res(药学服务与研究),2009,9(1):36-40.
[7]LIU G H,XUE G P,XING J G,et al.Study on extraction process of Compound Surunjiang Dripping Pill[J].Chin JMod Appl Pharm(中国现代应用药学),2013,30(4):399-403.
[8]LU W J,CHENG X M,TENG L,et al.Optimization of extraction process of total flavonoids from Anchusa italica Retz.by multi-index comprehensive score method[J].Shanghai J Tradit Chin Med(上海中医药杂志),2016,50(12):89-93.
[9]LI L,CHENG H Y,ZHU Y Y,et al.Optimal extraction of Zhizi Baipi Decoction by multi-index comprehensive scoring[J].Chin Tradit Pat Med(中成药),2015,37(2):306-310.
[10]HE J,GAO E S,LOU C H.Study on weight and standardization methods in comprehensive evaluation[J].China Public Health(中国公共卫生),2001,17(11):1048-1050.
[2]LI Z J,DAW U T,XIAO W,et al.AIBAI·Silafu2,3Antifungi of Euphorbia humifusa extract and its effect on ultrastructure of dermatophytes[J].Chin Tradit Herb Drugs(中草药),2009,40(5):758-763.
[3]LIU Y,LI Z C,CHEN J B.Therapeutic efficacy of small doses of colchicine combined with glucocorticoid for acute gouty arthritis[J].Med J Chin PLA(解放军医学杂志),2015,40(8):652-655.
[4]REN A N,LU A Q,TIAN Y Z,et al.AHP application to study of weighted coefficient on multicriteria optimization of extraction technology about Chinese traditional compound drugs[J].China J Chin Mater Med(中国中药杂志),2008,33(4):372-375.
[5]XIA P F,MA X,WANG J,et al.Evaluating the quality of Gentiana officinalis H.Smith with fuzzy matter-element model based on variation coefficient weight[J].Chin J Mod Appl Pharm(中国现代应用药学),2018,35(4):461-466.
[6]YANG M,ZHOU X,XIE R F,et al.Application of analytic hierarchy process(AHP)combined with CRITIC to studying weighted coefficient of multiple criteria for optimization of extraction technology of Compound Zishenqing granules[J].Pharm Care Res(药学服务与研究),2009,9(1):36-40.
[7]LIU G H,XUE G P,XING J G,et al.Study on extraction process of Compound Surunjiang Dripping Pill[J].Chin JMod Appl Pharm(中国现代应用药学),2013,30(4):399-403.
[8]LU W J,CHENG X M,TENG L,et al.Optimization of extraction process of total flavonoids from Anchusa italica Retz.by multi-index comprehensive score method[J].Shanghai J Tradit Chin Med(上海中医药杂志),2016,50(12):89-93.
[9]LI L,CHENG H Y,ZHU Y Y,et al.Optimal extraction of Zhizi Baipi Decoction by multi-index comprehensive scoring[J].Chin Tradit Pat Med(中成药),2015,37(2):306-310.
[10]HE J,GAO E S,LOU C H.Study on weight and standardization methods in comprehensive evaluation[J].China Public Health(中国公共卫生),2001,17(11):1048-1050.