细胞周期检测点激酶1在结直肠癌中的表达及其预后意义
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摘要
<正>结直肠癌是消化系统常见的恶性肿瘤,由于其发病较为隐匿,多数患者在就诊时已经到了中晚期,其死亡率仅次于肝癌和肺癌。结直肠癌的发生发展是多基因多因素共同作用的结果,其中细胞周期的调控对细胞的增殖起着重要的作用,细胞周期检测点激酶1(CHK1)是细胞周期检测中关键的蛋白激酶,主要在S期和G2/M期进行调控,是保证细胞周期正常运行和基因蛋白完整性的重要调节因子,与DNA损伤修复、凋亡及转录等有关~([1])。抑癌基因NPRL2也称肿瘤抑制候选基因4,广泛存在于人类组织中,NPRL2基因具有DNA错配修饰、调控细胞周期及诱导细胞凋亡的功能~([2,3])。本文通过检测结直肠癌中CHK1和NPRL2蛋白的表达情况,探讨
引文
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[3]马燕凌,孙建海,晏菲,等.肝细胞癌组织中抑癌基因NPRL2的表达及其意义[J].中华肝脏病杂志,2012,20(5):390-391.
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[5]姚磊,吴德全,唐志强.抑癌基因NPRL2的研究进展[J].肿瘤,2010,30(2):160-163.
[2] Otani S,Takeda S,Yamada S,et al. The tumor suppressor NPRL2 in hepatocellular carcinoma plays an important role in progression and can be served as an indepent prognostic factor[J]. J Surg Oncol,2009,100:358-363.
[3]马燕凌,孙建海,晏菲,等.肝细胞癌组织中抑癌基因NPRL2的表达及其意义[J].中华肝脏病杂志,2012,20(5):390-391.
[4] Lerman MI,Minna JD. The 630-kb lung cancer homozygous deletion region on human chromosolne 3p21.3:identification and evaluation of the resident candidate tumor suppressor gene[J].Cancer Res,2000,60(21):6116-6133.
[5]姚磊,吴德全,唐志强.抑癌基因NPRL2的研究进展[J].肿瘤,2010,30(2):160-163.