长链非编码RNA尿路上皮癌胚抗原1在实体瘤中的作用和机制
|
摘要
近年来大量研究显示许多长链非编码RNA(lncRNAs)在恶性肿瘤的发生发展过程中占有举足轻重的地位,其中尿路上皮癌胚抗原1(UCA1)最先被鉴定为膀胱癌致癌lncRNA,随后陆续在多种恶性肿瘤中发现异常高表达,并参与肿瘤细胞的增殖、迁移、侵袭等各种过程。本文就UCA1在泌尿系统肿瘤、消化系统肿瘤、肺癌、胶质瘤等其它人类恶性肿瘤中的作用和机制进行综述。
Long noncoding RNAs( lncRNAs) plays a pivotal role in the occurrence and development of malignant tumors. Urothelial cancer associated 1( UCA1) has been identified as bladder cancer carcinogenic lncRNA and it shows abnormal high expression in many cancers; it can be involved in various processes such as proliferation,migration and invasion of tumor cells. This paper reviewed the functions and mechanisms of UCA1 in urological tumors,digestive system tumors,lung tumor,glioma and other human malignancies.
Long noncoding RNAs( lncRNAs) plays a pivotal role in the occurrence and development of malignant tumors. Urothelial cancer associated 1( UCA1) has been identified as bladder cancer carcinogenic lncRNA and it shows abnormal high expression in many cancers; it can be involved in various processes such as proliferation,migration and invasion of tumor cells. This paper reviewed the functions and mechanisms of UCA1 in urological tumors,digestive system tumors,lung tumor,glioma and other human malignancies.
引文
[1] Siegel RL,Miller KD,Jemal A. Cancer statistics,2018[J]. CA Cancer J Clin,2018,68(1):7-30. DOI:10. 3322/caac. 21442.
[2] Mercer TR,Dinger ME,Mattick JS. Long non-coding RNAs:insights into functions[J]. Nat Rev Genet,2009,10(3):155-159. DOI:10. 1038/nrg2521.
[3] Linger RM,Keating AK,Earp HS,et al. TAM receptor tyrosine kinases:biologic functions,signaling,and potential therapeutic targeting in human cancer[J]. Adv Cancer Res,2008,100:35-83. DOI:10. 1016/S0065-230X(08)00002-X.
[4] Lian Y,Cai Z,Gong H,et al. HOTTIP:a critical oncogenic long non-coding RNA in human cancers[J]. Mol Biosyst,2016,12(11):3247-3253. DOI:10. 1039/c6mb00475j.
[5] Wang XS,Zhang Z,Wang HC,et al. Rapid identification of UCA1 as a very sensitive and specific unique marker for human bladder carcinoma[J]. Clin Cancer Res,2006,12(16):4851-4858. DOI:10. 1158/1078-0432. CCR-06-0134.
[6] Xue M,Li X,Li Z,et al. Urothelial carcinoma associated 1 is a hypoxia-inducible factor-1alpha-targeted long noncoding RNA that enhances hypoxic bladder cancer cell proliferation,migration,and invasion[J]. Tumour Biol,2014,35(7):6901-6912. DOI:10.1007/s13277-014-1925-x.
[7] Xue M,Li X,Wu W,et al. Upregulation of long non-coding RNA urothelial carcinoma associated 1 by CCAAT/enhancer binding proteinαcontributes to bladder cancer cell growth and reduced apoptosis[J]. Oncol Rep,2014,31(5):1993-2000. DOI:10.3892/or. 2014. 3092.
[8] Xue M,Pang H,Li X,et al. Long non-coding RNA urothelial cancer-associated 1 promotes bladder cancer cell migration and invasion by way of the hsa-miR-145-ZEB1/2-FSCN1 pathway[J].Cancer Sci,2016,107(1):18-27. DOI:10. 1111/cas. 12844.
[9] Li HJ,Sun XM,Li ZK,et al. LncRNA UCA1 promotes mitochondrial function of bladder cancer via the MiR-195/ARL2 signaling pathway[J]. Cell Physiol Biochem,2017,43(6):2548-2561.DOI:10. 1159/000484507.
[10] Luo J,Chen J,Li H,et al. LncRNA UCA1 promotes the invasion and EMT of bladder cancer cells by regulating the miR-143/HMGB1 pathway[J]. Oncol Lett,2017,14(5):5556-5562.DOI:10. 3892/ol. 2017. 6886.
[11] Xue M,Chen W,Xiang A,et al. Hypoxic exosomes facilitate bladder tumor growth and development through transferring long non-coding RNA-UCA1[J]. Mol Cancer,2017,16(1):143.DOI:10. 1186/s12943-017-0714-8.
[12] Zhang S,Dong X,Ji T,et al. Long non-coding RNA UCA1promotes cell progression by acting as a competing endogenous RNA of ATF2 in prostate cancer[J]. Am J Transl Res,2017,9(2):366-375.
[13] Lu Y,Liu WG,Lu JH,et al. LncRNA UCA1 promotes renal cell carcinoma proliferation through epigenetically repressing p21expression and negatively regulating miR-495[J]. Tumour Biol,2017,39(5):1010428317701632. DOI:10. 1177/1010428317701632.
[14] Li JY,Ma X,Zhang CB. Overexpression of long non-coding RNA UCA1 predicts a poor prognosis in patients with esophageal squamous cell carcinoma[J]. Int J Clin Exp Pathol,2014,7(11):7938-7944.
[15] Nasrollahzadeh-Khakiani M, Emadi-Baygi M, Nikpour P.Augmented expression levels of lncRNAs ec CEBPA and UCA1 in gastric cancer tissues and their clinical significance[J]. Iran J Basic Med Sci,2017,20(10):1149-1158. DOI:10. 22038/IJBMS. 2017. 9448.
[16] El-Tawdi AH,Matboli M,El-Nakeep S,et al. Association of long noncoding RNA and c-JUN expression in hepatocellular carcinoma[J]. Expert Rev Gastroenterol Hepatol,2016,10(7):869-877. DOI:10. 1080/17474124. 2016. 1193003.
[17] Han Y,Yang YN,Yuan HH,et al. UCA1,a long non-coding RNA up-regulated in colorectal cancer influences cell proliferation,apoptosis and cell cycle distribution[J]. Pathology,2014,46(5):396-401. DOI:10. 1097/PAT. 0000000000000125.
[18] Jiao C,Song Z,Chen J,et al. lncRNA-UCA1 enhances cell proliferation through functioning as a ceRNA of Sox4 in esophageal cancer[J]. Oncol Rep,2016,36(5):2960-2966. DOI:10.3892/or. 2016. 5121.
[19] Zhang M,Zhao Y,Zhang Y,et al. LncRNA UCA1 promotes migration and invasion in pancreatic cancer cells via the Hippo pathway[J]. Biochim Biophys Acta Mol Basis Dis,2018,1864(5 Pt A):1770-1782. DOI:10. 1016/j. bbadis. 2018. 03. 005.
[20] Moroishi T,Hansen CG,Guan KL. The emerging roles of YAP and TAZ in cancer[J]. Nat Rev Cancer,2015,15(2):73-79.DOI:10. 1038/nrc3876.
[21] Zhang X,Gao F,Zhou L,et al. UCA1 regulates the growth and metastasis of pancreatic cancer by sponging miR-135a[J]. Oncol Res,2017,25(9):1529-1541. DOI:10. 3727/096504017X14888987683152.
[22] Zhou Y,Chen Y,Ding W,et al. LncRNA UCA1 impacts cell proliferation,invasion,and migration of pancreatic cancer through regulating miR-96/FOXO3[J]. IUBMB Life,2018,70(4):276-290. DOI:10. 1002/iub. 1699.
[23] Wang F,Ying HQ,He BS,et al. Upregulated lncRNA-UCA1contributes to progression of hepatocellular carcinoma through inhibition of miR-216b and activation of FGFR1/ERK signaling pathway[J]. Oncotarget,2015,6(10):7899-7917. DOI:10.18632/oncotarget. 3219.
[24] Hu JJ,Song W,Zhang SD,et al. HBx-upregulated lncRNA UCA1 promotes cell growth and tumorigenesis by recruiting EZH2and repressing p27Kip1/CDK2 signaling[J]. Sci Rep,2016(6):23521. DOI:10. 1038/srep23521.
[25] Shang C,Guo Y,Zhang J,et al. Silence of long noncoding RNA UCA1 inhibits malignant proliferation and chemotherapy resistance to adriamycin in gastric cancer[J]. Cancer Chemother Pharmacol,2016,77(5):1061-1067. DOI:10. 1007/s00280-016-3029-3.
[26] Wang ZQ,He CY,Hu L,et al. Long noncoding RNA UCA1promotes tumour metastasis by inducing GRK2 degradation in gastric cancer[J]. Cancer Lett,2017(408):10-21. DOI:10.1016/j. canlet. 2017. 08. 013.
[27] Li C,Liang G,Yang S,et al. Dysregulated lncRNA-UCA1contributes to the progression of gastric cancer through regulation of the PI3K-Akt-mTOR signaling pathway[J]. Oncotarget,2017,8(55):93476-93491. DOI:10. 18632/oncotarget. 19281.
[28] Bian Z,Jin L,Zhang J,et al. LncRNA-UCA1 enhances cell proliferation and 5-fluorouracil resistance in colorectal cancer by inhibiting miR-204-5p[J]. Sci Rep,2016(6):23892. DOI:10.1038/srep23892.
[29] Cheng N,Cai W,Ren S,et al. Long non-coding RNA UCA1induces non-T790M acquired resistance to EGFR-TKIs by activating the AKT/m TOR pathway in EGFR-mutant non-small cell lung cancer[J]. Oncotarget,2015,6(27):23582-23593. DOI:10.18632/oncotarget. 4361.
[30] Li D,Li H,Yang Y,et al. Long noncoding RNA urothelial carcinoma associated 1 promotes the proliferation and metastasis of human lung tumor cells by regulating microRNA-144[J]. Oncol Res,2018,26(4):537-546. DOI:10. 3727/096504017X15009792179602.
[31] Wu H,Zhou C. Long non-coding RNA UCA1 promotes lung cancer cell proliferation and migration via microRNA-193a/HMGB1 axis[J].Biochem Biophys Res Commun,2018,496(2):738-745. DOI:10.1016/j. bbrc. 2018. 01. 097.
[32] Zhao W,Sun C,Cui Z. A long noncoding RNA UCA1 promotes proliferation and predicts poor prognosis in glioma[J]. Clin Transl Oncol,2017,19(6):735-741. DOI:10. 1007/s12094-016-1597-7.
[33] He Z,Wang Y,Huang G,et al. The lncRNA UCA1 interacts with miR-182 to modulate glioma proliferation and migration by targeting i ASPP[J]. Arch Biochem Biophys,2017,623-624:1-8. DOI:10. 1016/j. abb. 2017. 01. 013.
[34] He Z,You C,Zhao D. Long non-coding RNA UCA1/miR-182/PFKFB2 axis modulates glioblastoma-associated stromal cells-mediated glycolysis and invasion of glioma cells[J]. Biochem Biophys Res Commun,2018,500(3):569-576. DOI:10. 1016/j. bbrc. 2018.04. 091.
[35] Sun Y,Jin JG,Mi WY,et al. Long noncoding RNA UCA1 targets miR-122 to promote proliferation, migration, and invasion of glioma cells[J]. Oncol Res,2018,26(1):103-110. DOI:10.3727/096504017X14934860122864.
[36] Zhang ZS,Wang J,Zhu BQ,et al. Long noncoding RNA UCA1promotes multiple myeloma cell growth by targeting TGF-beta[J].Eur Rev Med Pharmacol Sci,2018,22(5):1374-1379. DOI:10.26355/eurrev_201803_14481.
[37] Li W,Xie P,Ruan WH. Overexpression of lncRNA UCA1 promotes osteosarcoma progression and correlates with poor prognosis[J]. J Bone Oncol,2016,5(2):80-85. DOI:10. 1016/j. jbo. 2016.05. 003.
[38] Wen JJ,Ma YD,Yang GS,et al. Analysis of circulating long non-coding RNA UCA1 as potential biomarkers for diagnosis and prognosis of osteosarcoma[J]. Eur Rev Med Pharmacol Sci,2017,21(3):498-503.
[39] Li T,Xiao Y,Huang T. HIF-1α-induced upregulation of lncRNA UCA1 promotes cell growth in osteosarcoma by inactivating the PTEN/AKT signaling pathway[J]. Oncol Rep,2018,39(3):1072-1080. DOI:10. 3892/or. 2018. 6182.
[40] Yan Q,Tian Y,Hao F. Downregulation of lncRNA UCA1 inhibits proliferation and invasion of cervical cancer cells through miR-206expression[J]. Oncol Res,2018. DOI:10. 3727/096504018X15185714083446.[Epub ahead of print]
[41] Wang B,Huang Z,Gao R,et al. Expression of long noncoding RNA urothelial cancer associated 1 promotes cisplatin resistance in cervical cancer[J]. Cancer Biother Radiopharm,2017,32(3):101-110. DOI:10. 1089/cbr. 2016. 2156.
[42] Wei Y,Sun Q,Zhao L,et al. LncRNA UCA1-miR-507-FOXM1axis is involved in cell proliferation,invasion and G0/G1 cell cycle arrest in melanoma[J]. Med Oncol,2016,33(8):88. DOI:10.1007/s12032-016-0804-2.
[2] Mercer TR,Dinger ME,Mattick JS. Long non-coding RNAs:insights into functions[J]. Nat Rev Genet,2009,10(3):155-159. DOI:10. 1038/nrg2521.
[3] Linger RM,Keating AK,Earp HS,et al. TAM receptor tyrosine kinases:biologic functions,signaling,and potential therapeutic targeting in human cancer[J]. Adv Cancer Res,2008,100:35-83. DOI:10. 1016/S0065-230X(08)00002-X.
[4] Lian Y,Cai Z,Gong H,et al. HOTTIP:a critical oncogenic long non-coding RNA in human cancers[J]. Mol Biosyst,2016,12(11):3247-3253. DOI:10. 1039/c6mb00475j.
[5] Wang XS,Zhang Z,Wang HC,et al. Rapid identification of UCA1 as a very sensitive and specific unique marker for human bladder carcinoma[J]. Clin Cancer Res,2006,12(16):4851-4858. DOI:10. 1158/1078-0432. CCR-06-0134.
[6] Xue M,Li X,Li Z,et al. Urothelial carcinoma associated 1 is a hypoxia-inducible factor-1alpha-targeted long noncoding RNA that enhances hypoxic bladder cancer cell proliferation,migration,and invasion[J]. Tumour Biol,2014,35(7):6901-6912. DOI:10.1007/s13277-014-1925-x.
[7] Xue M,Li X,Wu W,et al. Upregulation of long non-coding RNA urothelial carcinoma associated 1 by CCAAT/enhancer binding proteinαcontributes to bladder cancer cell growth and reduced apoptosis[J]. Oncol Rep,2014,31(5):1993-2000. DOI:10.3892/or. 2014. 3092.
[8] Xue M,Pang H,Li X,et al. Long non-coding RNA urothelial cancer-associated 1 promotes bladder cancer cell migration and invasion by way of the hsa-miR-145-ZEB1/2-FSCN1 pathway[J].Cancer Sci,2016,107(1):18-27. DOI:10. 1111/cas. 12844.
[9] Li HJ,Sun XM,Li ZK,et al. LncRNA UCA1 promotes mitochondrial function of bladder cancer via the MiR-195/ARL2 signaling pathway[J]. Cell Physiol Biochem,2017,43(6):2548-2561.DOI:10. 1159/000484507.
[10] Luo J,Chen J,Li H,et al. LncRNA UCA1 promotes the invasion and EMT of bladder cancer cells by regulating the miR-143/HMGB1 pathway[J]. Oncol Lett,2017,14(5):5556-5562.DOI:10. 3892/ol. 2017. 6886.
[11] Xue M,Chen W,Xiang A,et al. Hypoxic exosomes facilitate bladder tumor growth and development through transferring long non-coding RNA-UCA1[J]. Mol Cancer,2017,16(1):143.DOI:10. 1186/s12943-017-0714-8.
[12] Zhang S,Dong X,Ji T,et al. Long non-coding RNA UCA1promotes cell progression by acting as a competing endogenous RNA of ATF2 in prostate cancer[J]. Am J Transl Res,2017,9(2):366-375.
[13] Lu Y,Liu WG,Lu JH,et al. LncRNA UCA1 promotes renal cell carcinoma proliferation through epigenetically repressing p21expression and negatively regulating miR-495[J]. Tumour Biol,2017,39(5):1010428317701632. DOI:10. 1177/1010428317701632.
[14] Li JY,Ma X,Zhang CB. Overexpression of long non-coding RNA UCA1 predicts a poor prognosis in patients with esophageal squamous cell carcinoma[J]. Int J Clin Exp Pathol,2014,7(11):7938-7944.
[15] Nasrollahzadeh-Khakiani M, Emadi-Baygi M, Nikpour P.Augmented expression levels of lncRNAs ec CEBPA and UCA1 in gastric cancer tissues and their clinical significance[J]. Iran J Basic Med Sci,2017,20(10):1149-1158. DOI:10. 22038/IJBMS. 2017. 9448.
[16] El-Tawdi AH,Matboli M,El-Nakeep S,et al. Association of long noncoding RNA and c-JUN expression in hepatocellular carcinoma[J]. Expert Rev Gastroenterol Hepatol,2016,10(7):869-877. DOI:10. 1080/17474124. 2016. 1193003.
[17] Han Y,Yang YN,Yuan HH,et al. UCA1,a long non-coding RNA up-regulated in colorectal cancer influences cell proliferation,apoptosis and cell cycle distribution[J]. Pathology,2014,46(5):396-401. DOI:10. 1097/PAT. 0000000000000125.
[18] Jiao C,Song Z,Chen J,et al. lncRNA-UCA1 enhances cell proliferation through functioning as a ceRNA of Sox4 in esophageal cancer[J]. Oncol Rep,2016,36(5):2960-2966. DOI:10.3892/or. 2016. 5121.
[19] Zhang M,Zhao Y,Zhang Y,et al. LncRNA UCA1 promotes migration and invasion in pancreatic cancer cells via the Hippo pathway[J]. Biochim Biophys Acta Mol Basis Dis,2018,1864(5 Pt A):1770-1782. DOI:10. 1016/j. bbadis. 2018. 03. 005.
[20] Moroishi T,Hansen CG,Guan KL. The emerging roles of YAP and TAZ in cancer[J]. Nat Rev Cancer,2015,15(2):73-79.DOI:10. 1038/nrc3876.
[21] Zhang X,Gao F,Zhou L,et al. UCA1 regulates the growth and metastasis of pancreatic cancer by sponging miR-135a[J]. Oncol Res,2017,25(9):1529-1541. DOI:10. 3727/096504017X14888987683152.
[22] Zhou Y,Chen Y,Ding W,et al. LncRNA UCA1 impacts cell proliferation,invasion,and migration of pancreatic cancer through regulating miR-96/FOXO3[J]. IUBMB Life,2018,70(4):276-290. DOI:10. 1002/iub. 1699.
[23] Wang F,Ying HQ,He BS,et al. Upregulated lncRNA-UCA1contributes to progression of hepatocellular carcinoma through inhibition of miR-216b and activation of FGFR1/ERK signaling pathway[J]. Oncotarget,2015,6(10):7899-7917. DOI:10.18632/oncotarget. 3219.
[24] Hu JJ,Song W,Zhang SD,et al. HBx-upregulated lncRNA UCA1 promotes cell growth and tumorigenesis by recruiting EZH2and repressing p27Kip1/CDK2 signaling[J]. Sci Rep,2016(6):23521. DOI:10. 1038/srep23521.
[25] Shang C,Guo Y,Zhang J,et al. Silence of long noncoding RNA UCA1 inhibits malignant proliferation and chemotherapy resistance to adriamycin in gastric cancer[J]. Cancer Chemother Pharmacol,2016,77(5):1061-1067. DOI:10. 1007/s00280-016-3029-3.
[26] Wang ZQ,He CY,Hu L,et al. Long noncoding RNA UCA1promotes tumour metastasis by inducing GRK2 degradation in gastric cancer[J]. Cancer Lett,2017(408):10-21. DOI:10.1016/j. canlet. 2017. 08. 013.
[27] Li C,Liang G,Yang S,et al. Dysregulated lncRNA-UCA1contributes to the progression of gastric cancer through regulation of the PI3K-Akt-mTOR signaling pathway[J]. Oncotarget,2017,8(55):93476-93491. DOI:10. 18632/oncotarget. 19281.
[28] Bian Z,Jin L,Zhang J,et al. LncRNA-UCA1 enhances cell proliferation and 5-fluorouracil resistance in colorectal cancer by inhibiting miR-204-5p[J]. Sci Rep,2016(6):23892. DOI:10.1038/srep23892.
[29] Cheng N,Cai W,Ren S,et al. Long non-coding RNA UCA1induces non-T790M acquired resistance to EGFR-TKIs by activating the AKT/m TOR pathway in EGFR-mutant non-small cell lung cancer[J]. Oncotarget,2015,6(27):23582-23593. DOI:10.18632/oncotarget. 4361.
[30] Li D,Li H,Yang Y,et al. Long noncoding RNA urothelial carcinoma associated 1 promotes the proliferation and metastasis of human lung tumor cells by regulating microRNA-144[J]. Oncol Res,2018,26(4):537-546. DOI:10. 3727/096504017X15009792179602.
[31] Wu H,Zhou C. Long non-coding RNA UCA1 promotes lung cancer cell proliferation and migration via microRNA-193a/HMGB1 axis[J].Biochem Biophys Res Commun,2018,496(2):738-745. DOI:10.1016/j. bbrc. 2018. 01. 097.
[32] Zhao W,Sun C,Cui Z. A long noncoding RNA UCA1 promotes proliferation and predicts poor prognosis in glioma[J]. Clin Transl Oncol,2017,19(6):735-741. DOI:10. 1007/s12094-016-1597-7.
[33] He Z,Wang Y,Huang G,et al. The lncRNA UCA1 interacts with miR-182 to modulate glioma proliferation and migration by targeting i ASPP[J]. Arch Biochem Biophys,2017,623-624:1-8. DOI:10. 1016/j. abb. 2017. 01. 013.
[34] He Z,You C,Zhao D. Long non-coding RNA UCA1/miR-182/PFKFB2 axis modulates glioblastoma-associated stromal cells-mediated glycolysis and invasion of glioma cells[J]. Biochem Biophys Res Commun,2018,500(3):569-576. DOI:10. 1016/j. bbrc. 2018.04. 091.
[35] Sun Y,Jin JG,Mi WY,et al. Long noncoding RNA UCA1 targets miR-122 to promote proliferation, migration, and invasion of glioma cells[J]. Oncol Res,2018,26(1):103-110. DOI:10.3727/096504017X14934860122864.
[36] Zhang ZS,Wang J,Zhu BQ,et al. Long noncoding RNA UCA1promotes multiple myeloma cell growth by targeting TGF-beta[J].Eur Rev Med Pharmacol Sci,2018,22(5):1374-1379. DOI:10.26355/eurrev_201803_14481.
[37] Li W,Xie P,Ruan WH. Overexpression of lncRNA UCA1 promotes osteosarcoma progression and correlates with poor prognosis[J]. J Bone Oncol,2016,5(2):80-85. DOI:10. 1016/j. jbo. 2016.05. 003.
[38] Wen JJ,Ma YD,Yang GS,et al. Analysis of circulating long non-coding RNA UCA1 as potential biomarkers for diagnosis and prognosis of osteosarcoma[J]. Eur Rev Med Pharmacol Sci,2017,21(3):498-503.
[39] Li T,Xiao Y,Huang T. HIF-1α-induced upregulation of lncRNA UCA1 promotes cell growth in osteosarcoma by inactivating the PTEN/AKT signaling pathway[J]. Oncol Rep,2018,39(3):1072-1080. DOI:10. 3892/or. 2018. 6182.
[40] Yan Q,Tian Y,Hao F. Downregulation of lncRNA UCA1 inhibits proliferation and invasion of cervical cancer cells through miR-206expression[J]. Oncol Res,2018. DOI:10. 3727/096504018X15185714083446.[Epub ahead of print]
[41] Wang B,Huang Z,Gao R,et al. Expression of long noncoding RNA urothelial cancer associated 1 promotes cisplatin resistance in cervical cancer[J]. Cancer Biother Radiopharm,2017,32(3):101-110. DOI:10. 1089/cbr. 2016. 2156.
[42] Wei Y,Sun Q,Zhao L,et al. LncRNA UCA1-miR-507-FOXM1axis is involved in cell proliferation,invasion and G0/G1 cell cycle arrest in melanoma[J]. Med Oncol,2016,33(8):88. DOI:10.1007/s12032-016-0804-2.