药用真菌桑黄的研究进展
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摘要
桑黄是一类珍贵的药用真菌,具有很好的抗癌功效。本文综述了桑黄的菌种资源、药用价值、人工栽培技术等方面的研究进展,并对桑黄的应用前景和现阶段研究中存在的主要问题进行了讨论,以期为桑黄的开发利用及相关研究提供思路与参考。
Sanghuang is a kind of precious medicinal fungus with excellent anti-cancer effect. In this paper, we reviewed the research progress of medicinal fungus Sanghuang on the species resources, medicinal value, cultivation technology, etc. Moreover, application prospect of Sanghuang and its major research problems at present were also discussed to provide references for the development and utilization of Sanghuang as well as its related studies.
Sanghuang is a kind of precious medicinal fungus with excellent anti-cancer effect. In this paper, we reviewed the research progress of medicinal fungus Sanghuang on the species resources, medicinal value, cultivation technology, etc. Moreover, application prospect of Sanghuang and its major research problems at present were also discussed to provide references for the development and utilization of Sanghuang as well as its related studies.
引文
[1] 张维博,王家国,李正阔,等.药用真菌桑黄的研究进展[J].中国中药杂志,2014,15(39):2838-2845
[2] 甄权,尚志均.药性论[M].合肥:安徽科学技术出版社,2006:9
[3] 秦俊哲,王雪莲.桑黄菌的研究进展[J].食用菌,2007,29(6):3-4
[4] 王华林,温万芬.桑黄的药用价值研究进展[J].时珍国医国药,2015,11(26):2747-2750
[5] 宋力,孙焙龙,徐双阳,等.珍稀药用真菌桑黄的国内外研究进展[J].微生物学通报,2006,33(2):119
[6] 陈柳荫,肖婧,李菁,等.桑黄菌的研究进展[J].江西农业学报,2007,19(5):88-90
[7] HSIEH P W,WU J B,WU Y C.Chemistry and biology of Phellinus linteus[J].Bio Med,2013,3(3):106-113
[8] 刘正南,郑淑芳.中国药用真菌的现状和种质资源[J].中国食用菌,2001,20(4):22-24
[9] 戴玉成.药用担子菌:鲍氏层孔菌(桑黄)的新认识[J].中草药,2003,34(1):94-95
[10] 王波.生长在桑树上的真菌:桑黄[C]//中国菌物协会.2012年中国菌物学会学术年会会议摘要.北京:中国菌物协会,2012
[11] 骆冬青,郑红鹰,汪维云.珍稀药用真菌桑黄的研究进展[J].药物生物技术,2008,15(1):76-78
[12] 谢丽源,张勇,彭金华,等.桑黄真菌分子鉴定及遗传多样性分析[J].菌物学报,2010,29(3):347-356
[13] WU S H,DAI Y C,HATTORI T,et al.Species clarification for the medicinally valuable ‘sanghuang' mushroom[J].Bot Stud,2012,53(1):135-149
[14] 吴声华.珍贵药用菌“桑黄”物种正名[J].食药用菌,2012,20(3):177-179
[15] TIAN X M,YU H Y,ZHOU L W,et al.Phylogeny and taxonomy of the Inonotus linteus complex[J].Fungal Divers,2013,58(1):159-169
[16] 回晶,李辉,朱春玉,等.桑黄子实体与菌丝体营养成分的比较分析[J].特产研究,2009,31(2):59-61
[17] 齐欣,张峻,陈颖,等.六种不同树种桑黄有效成分的比较[J].食品科学,2010,31(6):199-201
[18] 朱琳,崔宝凯.药用真菌桑黄的研究进展[J].菌物研究,2016,14(4):201-209
[19] 夏国华.桑黄黄酮类成分及制剂研究[D].镇江:江苏大学,2011
[20] 莫顺燕,杨永春,石建功.桑黄化学成分研究[J].中国中药杂志,2003,28(4):339-341
[21] 吴长生.药用真菌桑黄成分的研究[D].济南:山东大学,2011
[22] 程鑫颖,包海鹰,丁燕,等.瓦宁木层孔菌中多酚和黄酮类成分分离及清除自由基活性的研究[J].菌物学报,2011,30(2):281-287
[23] 韦巍,李雪华.多糖的研究进展[J].国外医学药学分册,2005,32(3):179-184
[24] SAKALAUSKIENE J,AKRAMAS L,GLEIZNYS A,et al.Effects of β-1.3/1.6 glucan on cytokines production by leukocytes in vitro[J].Cent Eur J Med,2012,7(6):800-807
[25] YANG Y,YE L,ZHANG J,et al.Structural analysis of a bioactive polysaccharide,PISP1,from the medicinal mushroom Phellinus igniarius[J].Biosci Biotechnol Biochem,2009,73(1):134-139
[26] YANG Y,ZHANG J,LIU Y,et al.Structural elucidation of a 3-O-methyl-D-galactose-containing neutral polysaccharide from the fruiting bodies of Phellinus igniarius[J].Carbohydr Res,2007,342(8):1063-1070
[27] 葛青,毛建卫,张安强,等.桑黄子实体多糖的分离纯化及结构鉴定[J].菌食品科技,2013,38(3):168-175
[28] 江湖大川,揭晓,吴丹麦,等.桑黄活性成分的药理作用研究进展[J].浙江中西医结合杂志,2018,28(3):251-254
[29] 莫顺燕.药用真菌桑黄化学成分研究[D].北京:中国协和医科大学,2003
[30] WANG G J,TSAI T H,CHANG T T,et al.Lanostanes from Phellinus igniarius and their iNOS inhibitory activities[J].Planta Med,2009,75(15):1602-1607
[31] 梁佳,孙梦伊,张腾,等.响应曲面法优化桑黄菌丝中三萜的微波提取工艺[J].中国农学通报,2011,27(10):235-238
[32] LEE I K,HAN M S,LEE M S,et al.Styrylpyrones from the medicinal fungus Phellinus baumii and their antioxidant properties[J].Bioorg Med Chem Lett,2010,20(18):5459-5461
[33] MO S,WANG S,ZHOU G,et al.Phelligridins C-F:cytotoxic pyrano[4,3-c]benzopyran-1,6-dione and furo[3,2-c]pyran-4-dione derivatives from the fungus Phellinus igniarius[J].J Nat Prod,2004,67(5):823-828
[34] HWANG B S,LEE I K,CHOI H J,et al.Anti-influenza activities of polyphenols from the medicinal mushroom Phellinus baumii[J].Bioorg Med Chem Lett,2015,25(16):3256-3260
[35] 温克,陈劲,李红,等.桑黄等四种抗癌药物抗癌活性比较[J].吉林大学学报(医学版),2002,283(3):247-249
[36] 吴声华,黄冠中,陈愉萍,等.桑黄的分类及开发前景[J].菌物研究,2016,14(4):187-200
[37] 张林芳,孙婷婷,邹莉.鲍姆纤孔菌总三萜的提取及其体外抗乳腺癌细胞MCF-7活性[J].药物评价研究,2015,38(5):497-502
[38] LI Y G,JI D F,ZHONG S,et al.Anti-tumor effects of proteoglycan from Phellinus linteus by immunomodulating and inhibiting Reg IV/EGFR/Akt signaling pathway in colorectal carcinoma[J].Int J Biol Macromol,2011,48(3):511-517
[39] XUE Q,SUN J,ZHAO M W,et al.Immunostimulatory and anti-tumor activity of a water-soluble polysaccharide from Phellinus baumii mycelia[J].World J Microbiol Biotechnol,2011,27(5):1017-1023
[40] SUN J,CHEN Q J,ZHU M J,et al.An extracellular laccase with antiproliferative activity from the sanghuang mushroom Inonotus baumii[J].J Mol Catal,B,2014,99(1):20-25
[41] 尚亚靖.酚类抗氧化剂的结构修饰及其细节性机制研究[D].兰州:兰州大学,2010
[42] YANG Y,HU J,LIU Y.Antioxidant and cytotoxic activities of ethanolic extracts and isolated fractions of species of the genus Phellinus Quel.(Aphyllophoromycetideae)[J].Int J Med Mushrooms,2011,13(2):145-152
[43] KOZARSKI M,KLAUS A,NIKSIC M,et al.Antioxidative and immunomodulating activities of polysaccharide extracts of the medici-nal mushrooms Agaricus bisporus,Agaricus brasiliensis,Ganoderma lucidum and Phellinus linteus[J].Food Chem,2011,129(4):1667-1675
[44] 冯子旺.桑黄多酚的提取及其体外抗氧化、抗肿瘤活性研究[D].镇江:江苏大学,2012
[45] 张慧莹,吴海龙,姚德坤,等.桑黄素的研究进展[J].中国林副特产,2016(2):99-101
[46] KIM G Y,OH W K,SHIN B C,et al.Proteoglycan isolated from Phellinus linteus inhibits tumor growth through mechanisms leading to an activation of CD11c+CD8+DC and type Ⅰ helper T cell-dominant immune state[J].FEBS Lett,2004,576(3):391-400
[47] 傅海庆,陈绍军,陈汉清,等.桑黄口服液对小鼠免疫功能的影响[J].福建农业大学学报,2006,35(5):538-541
[48] KIM G Y,PARK S K,LEE M K,et al.Proteoglycan isolated from Phellinus linteus activates murine B lymphocytes via protein kinase C and protein tyrosine kinase[J].Int Immunopharmacol,2003,3(9):1281-1292
[49] 代荣,刘如明,肖建辉.菌类中药多糖降血糖效应机制研究进展[J].中国中药杂志,2015,40(2):174-179
[50] YAYEH T,LEE W M,KO D,et al.Phellinus baumii ethyl acetate extract alleviated collagen type Ⅱ induced arthritis in DBA/1 mice[J].J Nat Med,2013,67(4):807-813
[51] 李宜明,沈业寿,季俊虬,等.桑黄菌质多糖体外抑瘤及抗环磷酰胺致突变的作用[J].中国科学技术大学学报,2006,36(7):700-703
[52] CHO E J,HWANG H J,KIM S W,et al.Hypoglycemic effects of exopolysaccharides produced by mycelial cultures of two different mushrooms Tremella fuciformis and Phellinus baumic in ob/bo mice[J].Appl Microbiol Biot,2007,75(6):1257-1265
[53] WANG W H,WU F H,YANG Y,et al.Hypoglycemic effect of ethanol and ethyl acetate extract of Phellinus baumii fruiting body in streptozotocin-induced diabetic mice[J/OL].Evid Based Complement Alternat Med,2015,3:783460[2018-08-20].https://www.ncbi.nlm.nih.gov/pubmed/26221177.DOI:10.1155/2015/783460
[54] 刘红锦,蒋宁,张苏珍,等.桑黄人工培育研究进展[J].江西农业学报,2011,23(9):166-170
[55] 钟石,林天宝,吕志强,等.桑黄人工袋料栽培的初步研究[J].桑黄通报,2010,41(4):23;31
[56] 秦俊哲,李亚杰,帅斌.桑黄菌液体发酵工艺条件的研究[J].中国酿造,2010,29(11):92-95
[57] 王秋颖,陈邦国,秦绍新.桑黄菌人工栽培技术研究[J].食用菌,2005,27(5):32
[58] 杜萍,张春凤,崔宝凯,等.药用真菌桑黄的人工栽培技术研究[J].中国食用菌,2009,28(3):35-37
[59] 董宇,李洪玉,王娜妮,等.响应面法优化桑黄规模化人工栽培条件的研究[J].中药材,2015,38(12):2459-2463
[60] 唐丹,胡向南,王秋颖.人工种植“桑黄”最佳采收期的研究[J].中国农学通报,2013,29(31):211-214
[61] 胡文彬,马海乐,周存山.桑黄菌的研究与开发[J].食品研究与开发,2006,27(3):80-81
[62] 樊锦艳,王秋颖,薛梅,等.桑黄胞外多糖生产培养基的初步研究[J].食品科技,2004(2):93-95
[63] 何培新,吴双双,许春平.杨树桑黄胞外多糖发酵条件优化及形态学研究[J].食品研究与开发,2016,37(2):172-176
[64] 李朔,丁一新,许霁,等.桑黄胞内多糖液体发酵培养基的优化[J].食品科学,2006,27(11):236-240
[65] 田雪梅.桑黄类群真菌系统学及桑黄纤孔菌液体发酵研究[D].北京:北京林业大学,2014
[66] 蒋宁,刘红锦,张苏珍,等.桑黄菌丝固体培养基筛选研究[J].食用菌,2013,35(1):26-28
[67] 雷萍,孙悦迎,张文隽,等.野生桑黄菌种分离与培养特性研究初报[J].食用菌学报,2007,14(2):71-75
[2] 甄权,尚志均.药性论[M].合肥:安徽科学技术出版社,2006:9
[3] 秦俊哲,王雪莲.桑黄菌的研究进展[J].食用菌,2007,29(6):3-4
[4] 王华林,温万芬.桑黄的药用价值研究进展[J].时珍国医国药,2015,11(26):2747-2750
[5] 宋力,孙焙龙,徐双阳,等.珍稀药用真菌桑黄的国内外研究进展[J].微生物学通报,2006,33(2):119
[6] 陈柳荫,肖婧,李菁,等.桑黄菌的研究进展[J].江西农业学报,2007,19(5):88-90
[7] HSIEH P W,WU J B,WU Y C.Chemistry and biology of Phellinus linteus[J].Bio Med,2013,3(3):106-113
[8] 刘正南,郑淑芳.中国药用真菌的现状和种质资源[J].中国食用菌,2001,20(4):22-24
[9] 戴玉成.药用担子菌:鲍氏层孔菌(桑黄)的新认识[J].中草药,2003,34(1):94-95
[10] 王波.生长在桑树上的真菌:桑黄[C]//中国菌物协会.2012年中国菌物学会学术年会会议摘要.北京:中国菌物协会,2012
[11] 骆冬青,郑红鹰,汪维云.珍稀药用真菌桑黄的研究进展[J].药物生物技术,2008,15(1):76-78
[12] 谢丽源,张勇,彭金华,等.桑黄真菌分子鉴定及遗传多样性分析[J].菌物学报,2010,29(3):347-356
[13] WU S H,DAI Y C,HATTORI T,et al.Species clarification for the medicinally valuable ‘sanghuang' mushroom[J].Bot Stud,2012,53(1):135-149
[14] 吴声华.珍贵药用菌“桑黄”物种正名[J].食药用菌,2012,20(3):177-179
[15] TIAN X M,YU H Y,ZHOU L W,et al.Phylogeny and taxonomy of the Inonotus linteus complex[J].Fungal Divers,2013,58(1):159-169
[16] 回晶,李辉,朱春玉,等.桑黄子实体与菌丝体营养成分的比较分析[J].特产研究,2009,31(2):59-61
[17] 齐欣,张峻,陈颖,等.六种不同树种桑黄有效成分的比较[J].食品科学,2010,31(6):199-201
[18] 朱琳,崔宝凯.药用真菌桑黄的研究进展[J].菌物研究,2016,14(4):201-209
[19] 夏国华.桑黄黄酮类成分及制剂研究[D].镇江:江苏大学,2011
[20] 莫顺燕,杨永春,石建功.桑黄化学成分研究[J].中国中药杂志,2003,28(4):339-341
[21] 吴长生.药用真菌桑黄成分的研究[D].济南:山东大学,2011
[22] 程鑫颖,包海鹰,丁燕,等.瓦宁木层孔菌中多酚和黄酮类成分分离及清除自由基活性的研究[J].菌物学报,2011,30(2):281-287
[23] 韦巍,李雪华.多糖的研究进展[J].国外医学药学分册,2005,32(3):179-184
[24] SAKALAUSKIENE J,AKRAMAS L,GLEIZNYS A,et al.Effects of β-1.3/1.6 glucan on cytokines production by leukocytes in vitro[J].Cent Eur J Med,2012,7(6):800-807
[25] YANG Y,YE L,ZHANG J,et al.Structural analysis of a bioactive polysaccharide,PISP1,from the medicinal mushroom Phellinus igniarius[J].Biosci Biotechnol Biochem,2009,73(1):134-139
[26] YANG Y,ZHANG J,LIU Y,et al.Structural elucidation of a 3-O-methyl-D-galactose-containing neutral polysaccharide from the fruiting bodies of Phellinus igniarius[J].Carbohydr Res,2007,342(8):1063-1070
[27] 葛青,毛建卫,张安强,等.桑黄子实体多糖的分离纯化及结构鉴定[J].菌食品科技,2013,38(3):168-175
[28] 江湖大川,揭晓,吴丹麦,等.桑黄活性成分的药理作用研究进展[J].浙江中西医结合杂志,2018,28(3):251-254
[29] 莫顺燕.药用真菌桑黄化学成分研究[D].北京:中国协和医科大学,2003
[30] WANG G J,TSAI T H,CHANG T T,et al.Lanostanes from Phellinus igniarius and their iNOS inhibitory activities[J].Planta Med,2009,75(15):1602-1607
[31] 梁佳,孙梦伊,张腾,等.响应曲面法优化桑黄菌丝中三萜的微波提取工艺[J].中国农学通报,2011,27(10):235-238
[32] LEE I K,HAN M S,LEE M S,et al.Styrylpyrones from the medicinal fungus Phellinus baumii and their antioxidant properties[J].Bioorg Med Chem Lett,2010,20(18):5459-5461
[33] MO S,WANG S,ZHOU G,et al.Phelligridins C-F:cytotoxic pyrano[4,3-c]benzopyran-1,6-dione and furo[3,2-c]pyran-4-dione derivatives from the fungus Phellinus igniarius[J].J Nat Prod,2004,67(5):823-828
[34] HWANG B S,LEE I K,CHOI H J,et al.Anti-influenza activities of polyphenols from the medicinal mushroom Phellinus baumii[J].Bioorg Med Chem Lett,2015,25(16):3256-3260
[35] 温克,陈劲,李红,等.桑黄等四种抗癌药物抗癌活性比较[J].吉林大学学报(医学版),2002,283(3):247-249
[36] 吴声华,黄冠中,陈愉萍,等.桑黄的分类及开发前景[J].菌物研究,2016,14(4):187-200
[37] 张林芳,孙婷婷,邹莉.鲍姆纤孔菌总三萜的提取及其体外抗乳腺癌细胞MCF-7活性[J].药物评价研究,2015,38(5):497-502
[38] LI Y G,JI D F,ZHONG S,et al.Anti-tumor effects of proteoglycan from Phellinus linteus by immunomodulating and inhibiting Reg IV/EGFR/Akt signaling pathway in colorectal carcinoma[J].Int J Biol Macromol,2011,48(3):511-517
[39] XUE Q,SUN J,ZHAO M W,et al.Immunostimulatory and anti-tumor activity of a water-soluble polysaccharide from Phellinus baumii mycelia[J].World J Microbiol Biotechnol,2011,27(5):1017-1023
[40] SUN J,CHEN Q J,ZHU M J,et al.An extracellular laccase with antiproliferative activity from the sanghuang mushroom Inonotus baumii[J].J Mol Catal,B,2014,99(1):20-25
[41] 尚亚靖.酚类抗氧化剂的结构修饰及其细节性机制研究[D].兰州:兰州大学,2010
[42] YANG Y,HU J,LIU Y.Antioxidant and cytotoxic activities of ethanolic extracts and isolated fractions of species of the genus Phellinus Quel.(Aphyllophoromycetideae)[J].Int J Med Mushrooms,2011,13(2):145-152
[43] KOZARSKI M,KLAUS A,NIKSIC M,et al.Antioxidative and immunomodulating activities of polysaccharide extracts of the medici-nal mushrooms Agaricus bisporus,Agaricus brasiliensis,Ganoderma lucidum and Phellinus linteus[J].Food Chem,2011,129(4):1667-1675
[44] 冯子旺.桑黄多酚的提取及其体外抗氧化、抗肿瘤活性研究[D].镇江:江苏大学,2012
[45] 张慧莹,吴海龙,姚德坤,等.桑黄素的研究进展[J].中国林副特产,2016(2):99-101
[46] KIM G Y,OH W K,SHIN B C,et al.Proteoglycan isolated from Phellinus linteus inhibits tumor growth through mechanisms leading to an activation of CD11c+CD8+DC and type Ⅰ helper T cell-dominant immune state[J].FEBS Lett,2004,576(3):391-400
[47] 傅海庆,陈绍军,陈汉清,等.桑黄口服液对小鼠免疫功能的影响[J].福建农业大学学报,2006,35(5):538-541
[48] KIM G Y,PARK S K,LEE M K,et al.Proteoglycan isolated from Phellinus linteus activates murine B lymphocytes via protein kinase C and protein tyrosine kinase[J].Int Immunopharmacol,2003,3(9):1281-1292
[49] 代荣,刘如明,肖建辉.菌类中药多糖降血糖效应机制研究进展[J].中国中药杂志,2015,40(2):174-179
[50] YAYEH T,LEE W M,KO D,et al.Phellinus baumii ethyl acetate extract alleviated collagen type Ⅱ induced arthritis in DBA/1 mice[J].J Nat Med,2013,67(4):807-813
[51] 李宜明,沈业寿,季俊虬,等.桑黄菌质多糖体外抑瘤及抗环磷酰胺致突变的作用[J].中国科学技术大学学报,2006,36(7):700-703
[52] CHO E J,HWANG H J,KIM S W,et al.Hypoglycemic effects of exopolysaccharides produced by mycelial cultures of two different mushrooms Tremella fuciformis and Phellinus baumic in ob/bo mice[J].Appl Microbiol Biot,2007,75(6):1257-1265
[53] WANG W H,WU F H,YANG Y,et al.Hypoglycemic effect of ethanol and ethyl acetate extract of Phellinus baumii fruiting body in streptozotocin-induced diabetic mice[J/OL].Evid Based Complement Alternat Med,2015,3:783460[2018-08-20].https://www.ncbi.nlm.nih.gov/pubmed/26221177.DOI:10.1155/2015/783460
[54] 刘红锦,蒋宁,张苏珍,等.桑黄人工培育研究进展[J].江西农业学报,2011,23(9):166-170
[55] 钟石,林天宝,吕志强,等.桑黄人工袋料栽培的初步研究[J].桑黄通报,2010,41(4):23;31
[56] 秦俊哲,李亚杰,帅斌.桑黄菌液体发酵工艺条件的研究[J].中国酿造,2010,29(11):92-95
[57] 王秋颖,陈邦国,秦绍新.桑黄菌人工栽培技术研究[J].食用菌,2005,27(5):32
[58] 杜萍,张春凤,崔宝凯,等.药用真菌桑黄的人工栽培技术研究[J].中国食用菌,2009,28(3):35-37
[59] 董宇,李洪玉,王娜妮,等.响应面法优化桑黄规模化人工栽培条件的研究[J].中药材,2015,38(12):2459-2463
[60] 唐丹,胡向南,王秋颖.人工种植“桑黄”最佳采收期的研究[J].中国农学通报,2013,29(31):211-214
[61] 胡文彬,马海乐,周存山.桑黄菌的研究与开发[J].食品研究与开发,2006,27(3):80-81
[62] 樊锦艳,王秋颖,薛梅,等.桑黄胞外多糖生产培养基的初步研究[J].食品科技,2004(2):93-95
[63] 何培新,吴双双,许春平.杨树桑黄胞外多糖发酵条件优化及形态学研究[J].食品研究与开发,2016,37(2):172-176
[64] 李朔,丁一新,许霁,等.桑黄胞内多糖液体发酵培养基的优化[J].食品科学,2006,27(11):236-240
[65] 田雪梅.桑黄类群真菌系统学及桑黄纤孔菌液体发酵研究[D].北京:北京林业大学,2014
[66] 蒋宁,刘红锦,张苏珍,等.桑黄菌丝固体培养基筛选研究[J].食用菌,2013,35(1):26-28
[67] 雷萍,孙悦迎,张文隽,等.野生桑黄菌种分离与培养特性研究初报[J].食用菌学报,2007,14(2):71-75