定量脑电图在健康人群中的应用研究
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摘要
目的:探讨定量脑电图在健康人群应用的意义,为早期发现脑功能异常提供有价值的客观依据。方法:对73例健康成人(分为偶饮酒组及不饮酒组)进行定量脑电图功率谱分析,记录安静闭目状态下的19导脑电信号,经快速傅里叶变换分别计算:(1)δ波、θ波、α波、β波和γ波等各频段的绝对值和相对值;(2)各波段每Hz的绝对值和相对值;(3)各频段(δ/θ、δ/α、δ/β、δ/高β、θ/α、θ/β、θ/高β、α/β、α/高β、β/高β)的比值;并将上述各项指标与纽约大学医学院的正常人脑电信号库做比对。结果:偶饮酒组β、β1、β2、β3和高β频段绝对功率分别在P4、T3、T6;P4、01、T4、T6;T3、T6;F3、F4、C3、C4、T3、T6和C3、C4、P4、T6、Pz导联显著低于健康组(P<0.05),γ频段在FP2、F4和Fz导联显著低于健康组(P<0.05)。偶饮酒组α1频段相对功率在FPl、FP2、F3、F4、C3、C4、P3、P4、01、02、F7、T3、T5、T6、Cz、Fz导联显著高于健康组,差异有统计学意义(P<0.05);α2频段相对功率在F3、F4、C4、F8、T6、Cz、Fz导联带显著低于对照组,差异有统计学意义(P<0.05)。偶饮酒组每Hz绝对值除β、β1、β2、β3和高β波在各脑区显著低于健康组(P<0.05)外,δ波频段在F3导联、γ2波频段在F8和FP2导联、α波频段在T6导联显著低于健康组(P<0.05);每Hz相对值γ2和高γ波频段F8导联显著低于健康组(P<0.05)。健康组与偶饮酒组各频段比值比较差异无统计学意义。偶饮组12例β/高βZ值≥3,健康组2例Z值≥3,差异有统计学意义(P<0.05)。结论:偶饮酒者定量脑电图指标与健康人群显著不同,定量脑电图功率谱分析有助于早期发现健康人群脑功能异常。
Objective:Discussed quantitative electroencephalography(qEEG)utility value in healthy population.Applied an objective basis for early detection of brain dysfunction.Methods:Total 28 occasional drinkers and as control group,45 normal adults qEEGs were analyzed.Resting-state qEEG during eyes closed was acquired by using19-electrodes system.Data including:(1)the absolute power and relative power ofδ,θ,α,β,γ;(2)the absolute power and the relative power of each frequency band per Hertz;3)the ratio ofδ/θ,δ/α,θ/β,δ/highβ,θ/α,θ/β,θ/highβ,α/β,α/highβandβ/highβ,which were calculated based on Fast Fourier Transform(FFT).All above data was compared with qEEGs database of New York Medical University School of Medicine.Results:The absolute frequency power ofβband(in P4,T3,T6 electrodes),β1 band(in P4,01,T4,T6 electrodes),β2 band(in T3,T6 electrodes),β3 band(in F3,F4,C3,C4,T3,T6 electrodes),highβband(in C3,C4,P4,T6,Pz electrodes)andγband(in FP2,F4,Fz electrodes)were significantly lower in occasional drinkers than normal population(P<0.05).Comparing with normal population,the relativeα1 band power in FPl,FP2,F3,F4,C3,C4,P3,P4,01,02,F7,T3,T5,T6,Cz,Fz electrodes were significantly higher and the relativeα2 band power in F3,F4,C4,F8,T6,Cz,Fz electrodes were significantly lower in occasional drinkers(P<0.05).The absolute power per Hz inβ,β1,β2,β3 and highβbands of whole areas were significantly lower in occasional drinkers group than normal population,as well asδband in F3,γ2 band in F8 and FP2,andαband in T6(P<0.05).The relative power per Hz ofγ2 band and highγband in F8 were significantly lower in occasional drinkers than healthy population(P<0.05).No significant differences in each band power ratio between two groups.β/highβZ score≥3 were different obviously in occasional drinkers group(12 cases)comparing with normal population(2 cases)(P<0.05).Conclusion:The qEEG indices are significantly different between occasional drinkers and healthy population,and qEEG frequency band analysis is helpful for the early detection of brain dysfunction in healthy subjects.
Objective:Discussed quantitative electroencephalography(qEEG)utility value in healthy population.Applied an objective basis for early detection of brain dysfunction.Methods:Total 28 occasional drinkers and as control group,45 normal adults qEEGs were analyzed.Resting-state qEEG during eyes closed was acquired by using19-electrodes system.Data including:(1)the absolute power and relative power ofδ,θ,α,β,γ;(2)the absolute power and the relative power of each frequency band per Hertz;3)the ratio ofδ/θ,δ/α,θ/β,δ/highβ,θ/α,θ/β,θ/highβ,α/β,α/highβandβ/highβ,which were calculated based on Fast Fourier Transform(FFT).All above data was compared with qEEGs database of New York Medical University School of Medicine.Results:The absolute frequency power ofβband(in P4,T3,T6 electrodes),β1 band(in P4,01,T4,T6 electrodes),β2 band(in T3,T6 electrodes),β3 band(in F3,F4,C3,C4,T3,T6 electrodes),highβband(in C3,C4,P4,T6,Pz electrodes)andγband(in FP2,F4,Fz electrodes)were significantly lower in occasional drinkers than normal population(P<0.05).Comparing with normal population,the relativeα1 band power in FPl,FP2,F3,F4,C3,C4,P3,P4,01,02,F7,T3,T5,T6,Cz,Fz electrodes were significantly higher and the relativeα2 band power in F3,F4,C4,F8,T6,Cz,Fz electrodes were significantly lower in occasional drinkers(P<0.05).The absolute power per Hz inβ,β1,β2,β3 and highβbands of whole areas were significantly lower in occasional drinkers group than normal population,as well asδband in F3,γ2 band in F8 and FP2,andαband in T6(P<0.05).The relative power per Hz ofγ2 band and highγband in F8 were significantly lower in occasional drinkers than healthy population(P<0.05).No significant differences in each band power ratio between two groups.β/highβZ score≥3 were different obviously in occasional drinkers group(12 cases)comparing with normal population(2 cases)(P<0.05).Conclusion:The qEEG indices are significantly different between occasional drinkers and healthy population,and qEEG frequency band analysis is helpful for the early detection of brain dysfunction in healthy subjects.
引文
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[12]Rangaswamy M,Porjesz B,Chorlian DB,et al.Theta power in the EEG of alcoholics[J].Alcohol Clin Exp Res,2003,27(4):607-615.
[13]Coutin-Churchman P,Moreno R,Anez Y,et al.Clinical correlates of quantitative EEG alterations in alcoholic patients[J].Clin Neurophysiol,2006,117(4):740-751.
[14]Nikulin VVI,Nikulina AV,Yamashita H,et al.Effects of alcohol on spontaneous neuronal oscillations:a combined magnetoencephalographyand electroencephalography study[J].Prog Neuropsychopharmacol Biol Psychiatry,2005,29(5):687-693.
[15]马玉宝,王薇薇,吴逊.酒精对定量脑电图影响的研究和动态观察[J].神经疾病与精神卫生,2010,10(4):338-341.
[16]Nunez-Jaramillo L,Vega-Perera P,Ramírez-Lugo L,et al.Quantitative electroencephalography analysis in university students with hazardous alcoholconsumption,but not alcohol dependence[J].Neuroreport,2015,26(10):555-560.
[2]尹小明.定量脑电图在缺血性脑卒中的临床应用与新进展[J].中风与神经疾病杂志,2016,33(3):283-285.
[3]Thatcher RW.Handbook of QEEG and EEG Biofeedback[M].2nd Edition:Anipublishing Co,2016.
[4]Waite RL,Oscar-Berman M,RBraverman E,et al.Quantitative Electroencephalography analysis(qEEG)of neuro-electro-adaptive therapy 12TM[NEAT12]up-regulates cortical potentials in an alcoholic during protracted abstinence:putative anti-craving implications[J].J Addict Res Ther,2014,5(1):1-7.
[5]Garn H,Waser M,Deistler M,et al.Quantitative EEGin Alzheimer's disease:cognitive state,resting state and association with disease severity[J].Int J Psychophysiol,2014,93(3):390-397.
[6]陈燕伟,王向宇,谢成金.定量脑电图对重型颅脑创伤长期意识障碍患者的清醒评估[J].中华神经外科杂志,2011,27(1):56-58.
[7]Harper J,Malone SM,Iacono WG.Impact of alcohol use on EEG dynamics of response inhibition:a cotwin control analysis[J].Addict Biol,2016,18(11):1-17.
[8]Babiloni CI,Carducci F,Lizio R,et al.Resting State Cortical Electroencephalographic Rhythms are Related to Gray Matter Volume in Subjects with Mild Cognitive Impairment and Alzheimer’s Disease[J].Hum Brain Mapp,2013,34(6):1427-1446.
[9]Chan JKI,Trinder J,Colrain IM,et al.The acute effects of alcohol on sleep electroencephalogram power spectra in late adolescence[J].Alcohol Clin Exp Res,2015,39(2):291-299.
[10]De Quesada-Martínez ME,Díaz-Pérez GF,HerreraRamos A,et al.Quantitative electroencephalography features and cognitive impairment in alcoholic patients[J].Rev Neurol,2007,44(2):81-88.
[11]Hughes JR,John ER.Conventional and quantitative electroencephalography in psychiatry[J].J Neuropsychiatry Clin Neurosci,1999,11(2):190-208.
[12]Rangaswamy M,Porjesz B,Chorlian DB,et al.Theta power in the EEG of alcoholics[J].Alcohol Clin Exp Res,2003,27(4):607-615.
[13]Coutin-Churchman P,Moreno R,Anez Y,et al.Clinical correlates of quantitative EEG alterations in alcoholic patients[J].Clin Neurophysiol,2006,117(4):740-751.
[14]Nikulin VVI,Nikulina AV,Yamashita H,et al.Effects of alcohol on spontaneous neuronal oscillations:a combined magnetoencephalographyand electroencephalography study[J].Prog Neuropsychopharmacol Biol Psychiatry,2005,29(5):687-693.
[15]马玉宝,王薇薇,吴逊.酒精对定量脑电图影响的研究和动态观察[J].神经疾病与精神卫生,2010,10(4):338-341.
[16]Nunez-Jaramillo L,Vega-Perera P,Ramírez-Lugo L,et al.Quantitative electroencephalography analysis in university students with hazardous alcoholconsumption,but not alcohol dependence[J].Neuroreport,2015,26(10):555-560.