加味芍药甘草汤治疗透析患者不宁腿综合征的临床观察
摘要
目的观察加味芍药甘草汤对血液透析及腹膜透析患者继发不宁腿综合征的治疗效果。方法将30例血液透析患者及12例腹膜透析患者随机分为治疗组及对照组,所有患者在常规透析及内科治疗基础上,对照组患者第1周普拉克索0.125 mg日3次口服,第2周0.25 mg日3次口服,第3周及第4周0.5 mg日3次口服,共服用4周。治疗组在对照组基础上予加味芍药甘草汤颗粒冲剂,分析2组患者在国际不宁腿综合征评分(IRLSSG)变化以及睡眠质量变化。结果治疗组患者国际不宁腿综合征评分(IRLSSG)及睡眠质量较对照组明显改善(P<0.05);治疗组总有效率显著优于对照组(P<0.05)。结论加味芍药甘草汤对血液透析及腹膜透析患者继发不宁腿综合征有较好的治疗效果。
引文
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[3]中华医学会神经病学分会帕金森病及运动障碍学组.不宁腿综合征的诊断标准和治疗指南[J].中华神经科杂志,2009,42(10):709-711.
[4]Allen R P,Picchietti D L,Garciaborreguero D,et al.Restless legs syndrome/Willis-Ekbom disease diagnostic criteria:updated International Restless Legs Syndrome Study Group(IRLSSG)consensus criteria--history,rationale,description,and significance[J].Sleep Medicine,2014,15(8):860.
[5]Innes K E,Flack K L,Selfe T K,et al.Restless Legs Syndrome in an Appalachian Primary Care Population:Prevalence,Demographic and Lifestyle Correlates,and Burden[J].Journal of Clinical Sleep Medicine Jcsm Official Publication of the American Academy of Sleep Medicine,2013,9(10):1065-1075.
[6]Mahaldar A R.Restless leg syndrome in chronic kidney disease[J].Clinical Queries Nephrology,2014,3(1):5-8.
[7]Dauvilliers Y,Benes H,Partinen M,et al.Rotigotine in Hemodialysis-Associated Restless Legs Syndrome:A Randomized Controlled Trial[J].American Journal of Kidney Diseases the Official Journal of the National Kidney Foundation,2016,68(3):434.
[8]Razazian N,Azimi H,Heidarnejadian J,et al.Gabapentin versus levodopa-c for the treatment of restless legs syndrome in hemodialysis patients:a randomized clinical trial[J].Saudi Journal of Kidney Diseases & Transplantation An Official Publication of the Saudi Center for Organ Transplantation Saudi Arabia,2015,26(2):271.
[9]Giannaki C D,Sakkas G K,Hadjigeorgiou G M,et al.Non-pharmacological management of periodic limb movements during hemodialysis session in patients with uremic restless legs syndrome[J].Asaio Journal,2010,56(6):538-542.
[10]Deng Y,Wu J,Qiang J.Efficacy of Intravenous Iron Sucrose in Hemodialysis Patients with Restless Legs Syndrome(RLS):A Randomized,Placebo-Controlled Study[J].Med Sci Monit,2017,23:1254-1260.
[11]吴勉华,王新月.中医内科学[M].北京:中国中医药出版社,2012.7.
[12]杨艳,李东华,王洋,等.大剂量使用芍药与甘草配伍解痉作用的研究[J].时珍国医国药,2013,24(2):347-349.
[13]陈晓峰,谢君.不同芍药甘草配伍用于溃疡性结肠炎的治疗作用及机制研究[J].湖南中医药大学学报,2017,37(10):1074-1077.
[14]刘陶世,赵新慧,段金廒,等.芍药甘草汤总苷抗炎镇痛作用的配伍研究[J].中药新药与临床药理,2007,18(6):427-430.
[15]高亚军,薛娟,姚院芳.芍药甘草汤联合西药治疗卒中后肌痉挛的疗效研究[J].湖南中医药大学学报,2017,37(5):544-547.
[16]马惠姿,李鸿培.失眠症的病因与分类[J].中国医刊,2003,38(5):21-23.
[17]洪传桃,张玉娟,吴立华.芍药甘草汤治疗腓肠肌痉挛疗效观察[J].光明中医,2015(8):1788-1789.
[18]李越峰,李廷利.四逆散中主要有效成分芍药苷对睡眠影响的实验研究[J].中成药,2011,33(4):690-692.
[19]常学辉,杜萌萌.浅议“失眠从肾论治[J].时珍国医国药,2014,(2):419-419.