细胞焦亡研究进展
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摘要
细胞焦亡是一种促炎性的细胞程序性死亡方式,其生化及形态学特征、发生机制都与细胞凋亡等其他细胞死亡方式有着显著的不同。细胞焦亡的发生不仅与感染性疾病有关,而且与代谢性疾病、神经系统疾病和动脉粥样硬化等疾病的发生、发展密切相关。通过对细胞焦亡发生机制及其与相关疾病发生、发展的关系进行研究,有利于了解这些疾病的发病机理,并为治愈这些疾病提供新的思路及作用靶点。
引文
1 Man SM,Karki R,Kanneganti TD. Molecular mechanisms and functions of pyroptosis,inflammatory caspases and inflammasomes in infectious diseases. Immunol Rev,2017,277:61~75.
2 Vande Walle L,Lamkanfi M. Pyroptosis. Curr Biol,2016,26:R568~R572.
3 Shi J,Zhao Y,Wang K,et al. Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death. Nature,2015,526:660~665.
4 Kayagaki N,Stowe IB,Lee BL,et al. Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling. Nature,2015,526:666~671.
5 Shi J,Gao W,Shao F. Pyroptosis:gasdermin-mediated programmed necrotic cell death. Trends Biochem Sci,2017,42:245~254.
6 Place DE,Kanneganti TD. Recent advances in inflammasome biology. Curr Opin Immunol,2017,50:32~38.
7 Zhang J,Yang Y,He W,et al. Necrosome core machinery:MLKL. Cell Mol Life Sci,2016,73:2153~2163.
8 Chen X,He WT,Hu L,et al. Pyroptosis is driven by nonselective gasdermin-D pore and its morphology is different from MLKL channel-mediated necroptosis. Cell Res,2016,26:1007~1020.
9 Zhang Y,Chen X,Gueydan C,et al. Plasma membrane changes during programmed cell deaths. Cell Res,2018,28:9~21.
10 邱珍,夏中元,周斌.细胞焦亡的研究进展.医学综述,2016,15:2935~2938.
11 Liu X,Zhang Z,Ruan J,et al. Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores.Nature,2016,535:153~158.
12 Kovacs SB,Miao EA. Gasdermins:effectors of pyroptosis.Trends Cell Biol,2017,27:673~684.
13 He WT,Wan H,Hu L,et al. Gasdermin D is an executor of pyroptosis and required for interleukin-1beta secretion.Cell Res,2015,25:1285~1298.
14 Ding J,Wang K,Liu W,et al. Pore-forming activity and structural autoinhibition of the gasdermin family. Nature,2016,535:111~116.
15 Aglietti RA,Dueber EC. Recent insights into the molecular mechanisms underlying pyroptosis and gasdermin family functions. Trends Immunol,2017,38:261~271.
16 Rogers C,Fernandes-Alnemri T,Mayes L,et al. Cleavage of DFNA5 by caspase-3 during apoptosis mediates progression to secondary necrotic/pyroptotic cell death. Nat Commun,2017,8:14128.
17 Wang Y,Gao W,Shi X,et al. Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin. Nature,2017,547:99~103.
18 Jorgensen I,Rayamajhi M,Miao EA. Programmed cell death as a defence against infection. Nat Rev Immunol,2017,17:151~164.
19 Doitsh G,Galloway NL,Geng X,et al. Cell death by pyroptosis drives CD4 T-cell depletion in HIV-1 infection.Nature,2014,505:509~514.
20 Rheinheimer J,de Souza BM,Cardoso NS,et al. Current role of the NLRP3 inflammasome on obesity and insulin resistance:A systematic review. Metabolism,2017,74:1~9.
21 Henao-Mejia J,Elinav E,Thaiss CA,Flavell RA. Inflammasomes and metabolic disease. Annu Rev Physiol,2014,76:57~78.
22 Jiang D,Chen S,Sun R,et al. The NLRP3 inflammasome:Role in metabolic disorders and regulation by metabolic pathways. Cancer Lett,2018,419:8~19.
23 α7 Nicotinic acetylcholine receptor-mediated anti-inflammatory actions modulate brain functions. Neurotransmitter,2016,3:e1303.
24 Heneka MT. Inflammasome activation and innate immunity in Alzheimer's disease. Brain Pathol,2017,27:220~222.
25 Zhou Y,Lu M,Du RH,et al. MicroRNA-7 targets Nodlike receptor protein 3 inflammasome to modulate neuroinflammation in the pathogenesis of Parkinson's disease. Mol Neurodegener,2016,11:28.
26 Minutoli L,Puzzolo D,Rinaldi M,et al. ROS-mediated NLRP3 inflammasome activation in brain,heart,kidney,and testis ischemia/reperfusion injury. Oxid Med Cell Longev,2016,2016:2183026.
27 Xu YJ,Zheng L,Hu YW,et al. Pyroptosis and its relationship to atherosclerosis. Clin Chim Acta,2018,476:28~37.
28 Altaf A,Qu P,Zhao Y,et al. NLRP3 inflammasome in peripheral blood monocytes of acute coronary syndrome patients and its relationship with statins. Coron Artery Dis,2015,26:409~421.
29 Hoseini Z,Sepahvand F,Rashidi B,et al. NLRP3 inflammasome:Its regulation and involvement in atherosclerosis.J Cell Physiol,2018,233:2116~2132.
30 Baldrighi M,Mallat Z,Li X. NLRP3 inflammasome pathways in atherosclerosis. Atherosclerosis,2017,267:127~138.
2 Vande Walle L,Lamkanfi M. Pyroptosis. Curr Biol,2016,26:R568~R572.
3 Shi J,Zhao Y,Wang K,et al. Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death. Nature,2015,526:660~665.
4 Kayagaki N,Stowe IB,Lee BL,et al. Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling. Nature,2015,526:666~671.
5 Shi J,Gao W,Shao F. Pyroptosis:gasdermin-mediated programmed necrotic cell death. Trends Biochem Sci,2017,42:245~254.
6 Place DE,Kanneganti TD. Recent advances in inflammasome biology. Curr Opin Immunol,2017,50:32~38.
7 Zhang J,Yang Y,He W,et al. Necrosome core machinery:MLKL. Cell Mol Life Sci,2016,73:2153~2163.
8 Chen X,He WT,Hu L,et al. Pyroptosis is driven by nonselective gasdermin-D pore and its morphology is different from MLKL channel-mediated necroptosis. Cell Res,2016,26:1007~1020.
9 Zhang Y,Chen X,Gueydan C,et al. Plasma membrane changes during programmed cell deaths. Cell Res,2018,28:9~21.
10 邱珍,夏中元,周斌.细胞焦亡的研究进展.医学综述,2016,15:2935~2938.
11 Liu X,Zhang Z,Ruan J,et al. Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores.Nature,2016,535:153~158.
12 Kovacs SB,Miao EA. Gasdermins:effectors of pyroptosis.Trends Cell Biol,2017,27:673~684.
13 He WT,Wan H,Hu L,et al. Gasdermin D is an executor of pyroptosis and required for interleukin-1beta secretion.Cell Res,2015,25:1285~1298.
14 Ding J,Wang K,Liu W,et al. Pore-forming activity and structural autoinhibition of the gasdermin family. Nature,2016,535:111~116.
15 Aglietti RA,Dueber EC. Recent insights into the molecular mechanisms underlying pyroptosis and gasdermin family functions. Trends Immunol,2017,38:261~271.
16 Rogers C,Fernandes-Alnemri T,Mayes L,et al. Cleavage of DFNA5 by caspase-3 during apoptosis mediates progression to secondary necrotic/pyroptotic cell death. Nat Commun,2017,8:14128.
17 Wang Y,Gao W,Shi X,et al. Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin. Nature,2017,547:99~103.
18 Jorgensen I,Rayamajhi M,Miao EA. Programmed cell death as a defence against infection. Nat Rev Immunol,2017,17:151~164.
19 Doitsh G,Galloway NL,Geng X,et al. Cell death by pyroptosis drives CD4 T-cell depletion in HIV-1 infection.Nature,2014,505:509~514.
20 Rheinheimer J,de Souza BM,Cardoso NS,et al. Current role of the NLRP3 inflammasome on obesity and insulin resistance:A systematic review. Metabolism,2017,74:1~9.
21 Henao-Mejia J,Elinav E,Thaiss CA,Flavell RA. Inflammasomes and metabolic disease. Annu Rev Physiol,2014,76:57~78.
22 Jiang D,Chen S,Sun R,et al. The NLRP3 inflammasome:Role in metabolic disorders and regulation by metabolic pathways. Cancer Lett,2018,419:8~19.
23 α7 Nicotinic acetylcholine receptor-mediated anti-inflammatory actions modulate brain functions. Neurotransmitter,2016,3:e1303.
24 Heneka MT. Inflammasome activation and innate immunity in Alzheimer's disease. Brain Pathol,2017,27:220~222.
25 Zhou Y,Lu M,Du RH,et al. MicroRNA-7 targets Nodlike receptor protein 3 inflammasome to modulate neuroinflammation in the pathogenesis of Parkinson's disease. Mol Neurodegener,2016,11:28.
26 Minutoli L,Puzzolo D,Rinaldi M,et al. ROS-mediated NLRP3 inflammasome activation in brain,heart,kidney,and testis ischemia/reperfusion injury. Oxid Med Cell Longev,2016,2016:2183026.
27 Xu YJ,Zheng L,Hu YW,et al. Pyroptosis and its relationship to atherosclerosis. Clin Chim Acta,2018,476:28~37.
28 Altaf A,Qu P,Zhao Y,et al. NLRP3 inflammasome in peripheral blood monocytes of acute coronary syndrome patients and its relationship with statins. Coron Artery Dis,2015,26:409~421.
29 Hoseini Z,Sepahvand F,Rashidi B,et al. NLRP3 inflammasome:Its regulation and involvement in atherosclerosis.J Cell Physiol,2018,233:2116~2132.
30 Baldrighi M,Mallat Z,Li X. NLRP3 inflammasome pathways in atherosclerosis. Atherosclerosis,2017,267:127~138.