丹溪痛风汤合升降散配合中药外敷治疗急性痛风性关节炎的效果研究
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摘要
目的:探究丹溪痛风汤合升降散配合中药外敷治疗急性痛风性关节炎的临床效果。方法:选取2016年5月-2017年4月本院收治的急性痛风性关节炎患者172例作为研究对象,按照随机数字表法将其分为观察组和对照组,各86例。对照组予以常规西药综合对症治疗,观察组在此基础上辅以丹溪痛风汤合升降散配合中药外敷治疗,观察比较两组临床疗效和控显率、治疗前后的实验室指标变化以及药物不良反应发生情况。结果:观察组临床控显率为80.2%明显高于对照组的62.8%,差异有统计学意义(χ~2=12.052,P<0.05)。治疗后,两组血尿酸(BUA)、C-反应蛋白(CRP)、红细胞沉降率(ESR)水平较治疗前均明显降低,且观察组均明显低于对照组,差异均有统计学意义(P<0.05)。两组均未发生严重药物不良反应。观察组轻度不良反应发生率为8.1%明显低于对照组的30.2%,差异有统计学意义(χ~2=10.045,P<0.05)。结论:丹溪痛风汤、升降散口服配合中药外敷辅助治疗急性痛风性关节炎的临床效果确切,可有效改善临床症状及关节功能,并可早期平稳血尿酸等实验室指标,且用药安全性较高。
Objective:To explore the clinical effect of Danxi Tongfeng Decoction and Shengjiang Powder combined with external application of traditional Chinese medicine in the treatment of acute gouty arthritis.Method:A total of 172 patients with acute gouty arthritis admitted in our hospital from May 2016 to April 2017 were selected as the study objects.According to the random number table method,they were divided into observation group and control group,86 cases in each group.The control group was given symptomatic treatment of conventional western medicine,the observation group was treated with Danxi Tongfeng Decoction and Shengjiang Powder combined with external application of traditional Chinese medicine on this basis.The clinical efficacy and control rate,changes of laboratory indicators before and after treatment and occurrence of drug adverse reactions between the two groups were observed and compared.Result:Theclinical control rate of the observation group was 80.2%,which was significantly higher than 62.8% of the control group,the difference was statistically significant( χ~2=12.052,P<0.05).After treatment,the levels of blood uric acid( BUA),C-reactive protein( CRP),erythrocyte sedimentation rate( ESR) in two groups were significantly lower than those before treatment,and the observation group were significantly lower than those in the control group,the differences were statistically significant( P<0.05).No serious drug adverse reactions occurred in two groups.The incidence of mild adverse reactions in the observation group was 8.1%,which was significantly lower than 30.2% in the control group,the difference was statistically significant( χ~2=10.045,P<0.05).Conclusion:Danxi Tongfeng Decoction and Shengjiang Powder combined with external application of traditional Chinese medicine in the treatment of acute gouty arthritis has definite clinical effect,can effectively improve clinical symptoms and joint function,can stabilize blood uric acid and other laboratory indicators in the early stage and the safety of medication is high.
Objective:To explore the clinical effect of Danxi Tongfeng Decoction and Shengjiang Powder combined with external application of traditional Chinese medicine in the treatment of acute gouty arthritis.Method:A total of 172 patients with acute gouty arthritis admitted in our hospital from May 2016 to April 2017 were selected as the study objects.According to the random number table method,they were divided into observation group and control group,86 cases in each group.The control group was given symptomatic treatment of conventional western medicine,the observation group was treated with Danxi Tongfeng Decoction and Shengjiang Powder combined with external application of traditional Chinese medicine on this basis.The clinical efficacy and control rate,changes of laboratory indicators before and after treatment and occurrence of drug adverse reactions between the two groups were observed and compared.Result:Theclinical control rate of the observation group was 80.2%,which was significantly higher than 62.8% of the control group,the difference was statistically significant( χ~2=12.052,P<0.05).After treatment,the levels of blood uric acid( BUA),C-reactive protein( CRP),erythrocyte sedimentation rate( ESR) in two groups were significantly lower than those before treatment,and the observation group were significantly lower than those in the control group,the differences were statistically significant( P<0.05).No serious drug adverse reactions occurred in two groups.The incidence of mild adverse reactions in the observation group was 8.1%,which was significantly lower than 30.2% in the control group,the difference was statistically significant( χ~2=10.045,P<0.05).Conclusion:Danxi Tongfeng Decoction and Shengjiang Powder combined with external application of traditional Chinese medicine in the treatment of acute gouty arthritis has definite clinical effect,can effectively improve clinical symptoms and joint function,can stabilize blood uric acid and other laboratory indicators in the early stage and the safety of medication is high.
引文
[1]杨小纯,刘维,吴沅皞.中医药治疗急性痛风性关节炎的最新研究进展[J].中国中医急症,2017,26(6):1011-1013.
[2]中华医学会风湿病学分会.原发性痛风诊断和治疗指南[J].中华风湿病学杂志,2011,15(6):410-413.
[3]郑筱英.中药新药临床研究指导原则[M].北京:中国医药科技出版社,2002:233-234.
[4]中华医学会.临床诊疗指南·风湿病分册[M].北京:人民卫生出版社,2005:57-58.
[5]韦雯冰,向彩春.用中医药治疗急性发作期痛风性关节炎的研究进展[J].当代医药论丛,2018,16(15):31-32.
[6]韦丽兰.中西医结合治疗痛风性关节炎研究现状[J].中外医学研究,2017,15(2):159-160.
[7]朱远飞.痛风性关节炎急性期中医治疗的规律探究[J].医药前沿,2016,6(2):321-322.
[8]段淑香,纪显玥,韩玉生,等.丹溪痛风胶囊对急性痛风性关节炎大鼠滑膜抗氧化活性的影响[J].齐齐哈尔医学院学报,2013,34(18):2653-2654.
[9]燕军玲.中药内服外敷治疗湿热瘀阻型痛风性关节炎急性发作的临床效果[J].河南医学研究,2017,26(9):1669-1670.
[10]蒋建鹏,张莉.痛风患者应用丹溪痛风方治疗的研究进展[J].医学信息,2017,30(7):21-22.
[11]武妤霞,郭颖,刘珊,等.周彩云教授论治痛风性关节炎急性期经验浅析[J].陕西中医,2017,38(5):654-655.
[12]邓国强.祛风通络汤治疗急性痛风性关节炎78例[J].陕西中医,2014,35(10):1316-1317.
[13]杨瑞宇,李兆福,李具宝,等.342例急性痛风性关节炎病例回顾性分析[J].光明中医,2013,28(8):1569-1571.
[14]李红娜,宋轶群,王清泉.浅述用自拟的升降散治疗外感风邪之火郁证的临床体会[J].当代医药论丛,2017,15(14):146-147.
[15]龙枫,刘文全.升降散临证验案举隅[J].湖南中医杂志,2018,34(1):103-104.
[16]项晓伟,唐吉平,周利,等.中医综合疗法治疗急性痛风性关节炎的临床观察[J].中国中医急症,2014,23(12):2296-2298.
[17]杨祎.中医结合治疗急性痛风性关节炎的临床观察[J].湖北中医杂志,2016,38(4):34-35.
[18]陈兴华,杨奕平.金黄膏外敷治疗急性痛风性关节炎的临床研究[J].中成药,2015,37(10):2331-2333.
[19]林晶.加味金黄膏外敷治疗急性痛风性关节炎的疗效观察与护理[J].海南医学,2013,24(16):2483-2486.
[20]李寅,陈岩松,马宝东.急性痛风性关节炎中医外治法研究进展[J].实用中医内科杂志,2013,27(1):145-146.
[21]周静,顾光照.中医外治法治疗急性痛风性关节炎50例疗效观察[J].贵阳中医学院学报,2016,38(6):34-37.
[2]中华医学会风湿病学分会.原发性痛风诊断和治疗指南[J].中华风湿病学杂志,2011,15(6):410-413.
[3]郑筱英.中药新药临床研究指导原则[M].北京:中国医药科技出版社,2002:233-234.
[4]中华医学会.临床诊疗指南·风湿病分册[M].北京:人民卫生出版社,2005:57-58.
[5]韦雯冰,向彩春.用中医药治疗急性发作期痛风性关节炎的研究进展[J].当代医药论丛,2018,16(15):31-32.
[6]韦丽兰.中西医结合治疗痛风性关节炎研究现状[J].中外医学研究,2017,15(2):159-160.
[7]朱远飞.痛风性关节炎急性期中医治疗的规律探究[J].医药前沿,2016,6(2):321-322.
[8]段淑香,纪显玥,韩玉生,等.丹溪痛风胶囊对急性痛风性关节炎大鼠滑膜抗氧化活性的影响[J].齐齐哈尔医学院学报,2013,34(18):2653-2654.
[9]燕军玲.中药内服外敷治疗湿热瘀阻型痛风性关节炎急性发作的临床效果[J].河南医学研究,2017,26(9):1669-1670.
[10]蒋建鹏,张莉.痛风患者应用丹溪痛风方治疗的研究进展[J].医学信息,2017,30(7):21-22.
[11]武妤霞,郭颖,刘珊,等.周彩云教授论治痛风性关节炎急性期经验浅析[J].陕西中医,2017,38(5):654-655.
[12]邓国强.祛风通络汤治疗急性痛风性关节炎78例[J].陕西中医,2014,35(10):1316-1317.
[13]杨瑞宇,李兆福,李具宝,等.342例急性痛风性关节炎病例回顾性分析[J].光明中医,2013,28(8):1569-1571.
[14]李红娜,宋轶群,王清泉.浅述用自拟的升降散治疗外感风邪之火郁证的临床体会[J].当代医药论丛,2017,15(14):146-147.
[15]龙枫,刘文全.升降散临证验案举隅[J].湖南中医杂志,2018,34(1):103-104.
[16]项晓伟,唐吉平,周利,等.中医综合疗法治疗急性痛风性关节炎的临床观察[J].中国中医急症,2014,23(12):2296-2298.
[17]杨祎.中医结合治疗急性痛风性关节炎的临床观察[J].湖北中医杂志,2016,38(4):34-35.
[18]陈兴华,杨奕平.金黄膏外敷治疗急性痛风性关节炎的临床研究[J].中成药,2015,37(10):2331-2333.
[19]林晶.加味金黄膏外敷治疗急性痛风性关节炎的疗效观察与护理[J].海南医学,2013,24(16):2483-2486.
[20]李寅,陈岩松,马宝东.急性痛风性关节炎中医外治法研究进展[J].实用中医内科杂志,2013,27(1):145-146.
[21]周静,顾光照.中医外治法治疗急性痛风性关节炎50例疗效观察[J].贵阳中医学院学报,2016,38(6):34-37.