大株红景天注射液治疗冠心病心绞痛有效性与安全性Meta分析
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摘要
目的心绞痛是由于短暂性心肌缺血导致的心前区压榨样疼痛,是冠状动脉粥样硬化性心脏病最常见的临床表现。本研究评价大株红景天注射液治疗冠心病心绞痛的有效性和安全性。方法检索PubMed、Medline、Embase、the Cochrane Library、中国期刊全文数据库、万方数据库、维普数据库中,大株红景天注射液在辅助治疗冠心病心绞痛方面的临床随机对照试验(randomized controlled trial,RCT),通过RevMan 5.3.3进行Meta分析。结果最终纳入27个RCTs,共计2 353例冠心病心绞痛患者。Meta分析结果显示,在常规治疗冠心病心绞痛基础上,辅以大株红景天注射液,临床总有效率显著提高(RR=1.24,95%CI为1.19～1.29,P<0.001)、心绞痛患者心电图改善明显(OR=2.57,95%CI为1.97～3.34,P<0.001)。结论冠心病心绞痛患者在常规西医治疗的基础上,辅以大株红景天注射液静脉滴入治疗,临床疗效显著,心电图改善效果明显,且安全性较高。
OBJECTIVE Angina pectoris is pressor-like pain in the anterior region caused by transient myocardial ischemia.It is the most common clinical manifestation of coronary atherosclerotic heart disease.This study evaluates the efficacy and safety of Sofren injection in the treatment of coronary heart disease angina pectoris.METHODS Retrieving PubMed,Medline,Embase,the Cochrane Library,Chinese Journal Full-text Database,Wanfang Database,and Weipu Database,Sofren injection in the treatment of coronary heart disease with angina pectoris in randomized controlled trial(RCT)were collected.Meta-analysis was performed by RevMan 5.3.3 software.RESULTS Twenty-seven RCTs were eventually enrolled,total 2 353 patients with coronary heart disease and angina pectoris.Meta-analysis results showed that on the basis of conventional treatment of coronary heart disease angina pectoris,supplemented by Sofren injection,the total clinical effective rate was significantly improved(RR=1.24,95%CI:1.19-1.29,P<0.001).The electrocardiogram of patients with angina pectoris improved significantly(OR=2.57,95%CI:1.97-3.34,P<0.001).CONCLUSIONS The patients with angina pectoris of coronary heart disease are treated by intravenous drip of Sofren injection on the basis of conventional western medicine.The clinical effect is remarkable,the electrocardiogram is improved obviously,and the safety is higher.
OBJECTIVE Angina pectoris is pressor-like pain in the anterior region caused by transient myocardial ischemia.It is the most common clinical manifestation of coronary atherosclerotic heart disease.This study evaluates the efficacy and safety of Sofren injection in the treatment of coronary heart disease angina pectoris.METHODS Retrieving PubMed,Medline,Embase,the Cochrane Library,Chinese Journal Full-text Database,Wanfang Database,and Weipu Database,Sofren injection in the treatment of coronary heart disease with angina pectoris in randomized controlled trial(RCT)were collected.Meta-analysis was performed by RevMan 5.3.3 software.RESULTS Twenty-seven RCTs were eventually enrolled,total 2 353 patients with coronary heart disease and angina pectoris.Meta-analysis results showed that on the basis of conventional treatment of coronary heart disease angina pectoris,supplemented by Sofren injection,the total clinical effective rate was significantly improved(RR=1.24,95%CI:1.19-1.29,P<0.001).The electrocardiogram of patients with angina pectoris improved significantly(OR=2.57,95%CI:1.97-3.34,P<0.001).CONCLUSIONS The patients with angina pectoris of coronary heart disease are treated by intravenous drip of Sofren injection on the basis of conventional western medicine.The clinical effect is remarkable,the electrocardiogram is improved obviously,and the safety is higher.
引文
[1]翁向群,庄聪文,石晓磊,等.大株红景天联合磷酸肌酸钠治疗不稳定型心绞痛疗效观察[J].临床军医杂志,2015,43(11):827-830.
[2]韩在刚.大株红景天注射液治疗冠心病心绞痛疗效观察[J].中国民康医学,2012,24(18):2198.
[3]唐彬,王志祥,罗庆文,等.大株红景天注射液治疗稳定型心绞痛疗效观察[J].云南中医中药杂志,2013,34(3):19-20.
[4]唐秋.大株红景天对稳定性心绞痛临床疗效及LP-PLA2、hsCRP影响的研究[D].南京:南京中医药大学,2016.
[5]李莉.大株红景天联合环磷腺苷葡胺治疗心绞痛疗效观察[J].山西医药杂志,2014,43(19):2310-2312.
[6]张颖,王媛,邓争荣.大株红景天注射液联合丹参多酚酸盐治疗不稳定型心绞痛的疗效观察[J].临床和实验医学杂志,2018,17(9):961-964.
[7]甘玉君.大株红景天注射液与注射用单硝酸异山梨酯治疗心绞痛116例疗效观察[J].山西医药杂志,2012,41(7):719-720.
[8]张由建.大株红景天注射液治疗不稳定心绞痛患者临床疗效观察[J].河南医学研究,2013,22(3):348-350.
[9]王亚宽,尚树忠,顾旭,等.大株红景天注射液治疗不稳定型心绞痛80例疗效观察[J].中医临床研究,2015,7(22):62-64.
[10]王海洋,杨守忠,杨小青.大株红景天注射液治疗冠心病稳定型心绞痛疗效及作用机制研究[J].中医药信息,2017,34(6):56-60.
[11]刘云霞,蒙瑞.大株红景天注射液治疗心绞痛疗效观察[J].求医问药(下半月),2012,10(10):281-282.
[12]曾广铨.大株红景天注射液配合穴位贴敷治疗冠心病不稳定心绞痛的疗效观察[J].临床检验杂志(电子版),2017,6(1):55-57.
[13]贾洪君,王国涛.大株红景天注射液对不稳定型心绞痛疗效及SOD、MDA的影响[J].黑龙江医学,2014,38(6):640-641.
[14]张建萍.大株红景天注射液治疗“心血瘀阻”型稳定性心绞痛疗效观察[J].中国医药导刊,2014,16(1):80-81.
[15]王加林,曹勇,罗正义.大株红景天注射液治疗冠心病心绞痛疗效观察[J].现代中西医结合杂志,2010,19(16):1978-1979.
[16]周丽.大株红景天注射液治疗心绞痛疗效及其对血小板抑制率的影响[J].亚太传统医药,2016,12(23):136-137.
[17]陈志冲,陈琳,程康林.大株红景天注射液治疗心绞痛的疗效及其对血小板抑制率的影响[J].实用心脑肺血管病杂志,2014,22(1):51-52.
[18]赵文雪,洪梅,贾志强.大株红景天治疗老年稳定性心绞痛的疗效[J].江苏医药,2015,41(17):2072-2073.
[19]张志华,徐崇利.大株红景天注射液与丹红注射液治疗冠心病心绞痛的疗效对比[J].中国老年保健医学,2015,13(6):23-25.
[20]曹鸿鹍,张云坤,傅薇,等.大株红景天对老年不稳定心绞痛疗效观察[J].医学信息,2014(30):272-273.
[21]秦建华,高阳.大株红景天治疗不稳定型心绞痛的疗效观察[J].医学理论与实践,2016,29(24):3345-3346.
[22]余德文,苏勇,杨宇,等.大株红景天治疗高龄老年人不稳定型心绞痛临床分析[J].西南国防医药,2011,21(12):1309-1311.
[23]李宝华.大株红景天注射液联合氯吡格雷治疗不稳定型心绞痛的疗效及对血小板功能的影响[J].临床医学,2017,37(10):99-100.
[24]侯丽媛,张媛,吴艳丽,等.大株红景天注射液治疗冠心病心绞痛疗效分析[J].中医临床研究,2018,10(7):76-77.
[25]蒯琳.大株红景天注射液治疗老年心绞痛患者疗效观察[J].医药前沿,2014(15):126-127.
[26]王秋爽.大株红景天注射液治疗稳定型心绞痛的疗效观察[J].中国保健营养(下旬刊),2013,23(8):4606.
[27]夏禹.大株红景天治疗心血瘀阻型心绞痛的疗效观察[J].内蒙古中医药,2015(5):8-9.
[2]韩在刚.大株红景天注射液治疗冠心病心绞痛疗效观察[J].中国民康医学,2012,24(18):2198.
[3]唐彬,王志祥,罗庆文,等.大株红景天注射液治疗稳定型心绞痛疗效观察[J].云南中医中药杂志,2013,34(3):19-20.
[4]唐秋.大株红景天对稳定性心绞痛临床疗效及LP-PLA2、hsCRP影响的研究[D].南京:南京中医药大学,2016.
[5]李莉.大株红景天联合环磷腺苷葡胺治疗心绞痛疗效观察[J].山西医药杂志,2014,43(19):2310-2312.
[6]张颖,王媛,邓争荣.大株红景天注射液联合丹参多酚酸盐治疗不稳定型心绞痛的疗效观察[J].临床和实验医学杂志,2018,17(9):961-964.
[7]甘玉君.大株红景天注射液与注射用单硝酸异山梨酯治疗心绞痛116例疗效观察[J].山西医药杂志,2012,41(7):719-720.
[8]张由建.大株红景天注射液治疗不稳定心绞痛患者临床疗效观察[J].河南医学研究,2013,22(3):348-350.
[9]王亚宽,尚树忠,顾旭,等.大株红景天注射液治疗不稳定型心绞痛80例疗效观察[J].中医临床研究,2015,7(22):62-64.
[10]王海洋,杨守忠,杨小青.大株红景天注射液治疗冠心病稳定型心绞痛疗效及作用机制研究[J].中医药信息,2017,34(6):56-60.
[11]刘云霞,蒙瑞.大株红景天注射液治疗心绞痛疗效观察[J].求医问药(下半月),2012,10(10):281-282.
[12]曾广铨.大株红景天注射液配合穴位贴敷治疗冠心病不稳定心绞痛的疗效观察[J].临床检验杂志(电子版),2017,6(1):55-57.
[13]贾洪君,王国涛.大株红景天注射液对不稳定型心绞痛疗效及SOD、MDA的影响[J].黑龙江医学,2014,38(6):640-641.
[14]张建萍.大株红景天注射液治疗“心血瘀阻”型稳定性心绞痛疗效观察[J].中国医药导刊,2014,16(1):80-81.
[15]王加林,曹勇,罗正义.大株红景天注射液治疗冠心病心绞痛疗效观察[J].现代中西医结合杂志,2010,19(16):1978-1979.
[16]周丽.大株红景天注射液治疗心绞痛疗效及其对血小板抑制率的影响[J].亚太传统医药,2016,12(23):136-137.
[17]陈志冲,陈琳,程康林.大株红景天注射液治疗心绞痛的疗效及其对血小板抑制率的影响[J].实用心脑肺血管病杂志,2014,22(1):51-52.
[18]赵文雪,洪梅,贾志强.大株红景天治疗老年稳定性心绞痛的疗效[J].江苏医药,2015,41(17):2072-2073.
[19]张志华,徐崇利.大株红景天注射液与丹红注射液治疗冠心病心绞痛的疗效对比[J].中国老年保健医学,2015,13(6):23-25.
[20]曹鸿鹍,张云坤,傅薇,等.大株红景天对老年不稳定心绞痛疗效观察[J].医学信息,2014(30):272-273.
[21]秦建华,高阳.大株红景天治疗不稳定型心绞痛的疗效观察[J].医学理论与实践,2016,29(24):3345-3346.
[22]余德文,苏勇,杨宇,等.大株红景天治疗高龄老年人不稳定型心绞痛临床分析[J].西南国防医药,2011,21(12):1309-1311.
[23]李宝华.大株红景天注射液联合氯吡格雷治疗不稳定型心绞痛的疗效及对血小板功能的影响[J].临床医学,2017,37(10):99-100.
[24]侯丽媛,张媛,吴艳丽,等.大株红景天注射液治疗冠心病心绞痛疗效分析[J].中医临床研究,2018,10(7):76-77.
[25]蒯琳.大株红景天注射液治疗老年心绞痛患者疗效观察[J].医药前沿,2014(15):126-127.
[26]王秋爽.大株红景天注射液治疗稳定型心绞痛的疗效观察[J].中国保健营养(下旬刊),2013,23(8):4606.
[27]夏禹.大株红景天治疗心血瘀阻型心绞痛的疗效观察[J].内蒙古中医药,2015(5):8-9.