清热利湿解毒法治疗带状疱疹湿热内蕴证疗效及对神经肽影响观察
|
摘要
目的:观察由清热利湿解毒法组成之痛痒灵汤治疗带状疱疹湿热内蕴证的临床疗效及对神经肽的影响。方法:150例带状疱疹湿热内蕴证患者随机分为中药组、西药组和综合组各50例,中药组以痛痒灵汤外涂,西药组以利巴韦林静滴,综合组以痛痒灵汤外涂联合利巴韦林静滴。14 d为1个疗程。比较临床疗效、临床症状改善时间、视觉模拟(VAS)评分,放免法检测血浆神经肽,记录不良反应。结果:综合组总有效率94.0%,明显高于西药组的66.0%和中药组的70.0%(P<0.05)。综合组止疱、结痂、治愈时间、VAS评分及血浆SP含量均明显低于其它两组,血浆β-EP含量明显高于其它两组(P<0.05)。3组均无明显不良反应出现。结论:清热利湿解毒法之痛痒灵汤治疗带状疱疹湿热内蕴证有较好的临床效果。
Objective: To observe the clinical effect of clearing heat and eliminating dampness and detoxification method in treating herpes zoster with interior dampness-heat syndrome and its impacts on neuropeptide. Methods:A total of 150 patients were randomly divided into traditional Chinese medicine(TCM) group(50 cases), western medicine group(50 cases) and comprehensive group(50 cases). The Chinese medicine group was treated with Tongyangling Decoction. The western medicine group was injected with ribavirin intravenously. The comprehensive group was treated with Tongyangling Decoction and injected ribavirin intravenously. All treated for 14 days,the clinical efficacy, the time of clinical symptoms improvement and VAS score were compared. The plasma level of neuropeptide was determined by radioimmunoassay and the adverse reactions were recorded. Results: For the comprehensive group, the clinical efficiency was 94.0%, which was higher than that in western medicine group(66.0%) and TCM group(70.0%)(P<0.05). Compared with the other two groups, the comprehensive group's stopping herpes time, lesion scabby time and healing time were shorter. The VAS score and the plasma level of SP were lower and the plasma level of β-EP was higher(P<0.05). No obvious adverse reactions were observed in the three groups. Conclusion: The clearing heat and eliminating dampness and detoxification method is effective for herpes zoster with interior dampness-heat syndrome.
Objective: To observe the clinical effect of clearing heat and eliminating dampness and detoxification method in treating herpes zoster with interior dampness-heat syndrome and its impacts on neuropeptide. Methods:A total of 150 patients were randomly divided into traditional Chinese medicine(TCM) group(50 cases), western medicine group(50 cases) and comprehensive group(50 cases). The Chinese medicine group was treated with Tongyangling Decoction. The western medicine group was injected with ribavirin intravenously. The comprehensive group was treated with Tongyangling Decoction and injected ribavirin intravenously. All treated for 14 days,the clinical efficacy, the time of clinical symptoms improvement and VAS score were compared. The plasma level of neuropeptide was determined by radioimmunoassay and the adverse reactions were recorded. Results: For the comprehensive group, the clinical efficiency was 94.0%, which was higher than that in western medicine group(66.0%) and TCM group(70.0%)(P<0.05). Compared with the other two groups, the comprehensive group's stopping herpes time, lesion scabby time and healing time were shorter. The VAS score and the plasma level of SP were lower and the plasma level of β-EP was higher(P<0.05). No obvious adverse reactions were observed in the three groups. Conclusion: The clearing heat and eliminating dampness and detoxification method is effective for herpes zoster with interior dampness-heat syndrome.
引文
[1] O’Connor KM,Paauw DS.Herpes zoster [J].Med Clin North Am,2013,97(4):503-522.
[2] 包烨华,陶承军,楚佳梅.中镇六穴结合梅花针刺络拔罐治疗带状疱疹后遗神经痛临床观察[J].中华中医药学刊,2010,28(10):2226-2228.
[3] Dayan RR,Peleg R.Herpes zoster-typical and atypical presentations[J].Postgrad Med,2017,129(6):567-571.
[4] 刘春阳,王莒生,刘志勇.针药联合治疗带状疱疹急性期肝经郁热证52例疗效观察[J].中医杂志,2017,58(21):1842-1845.
[5] 刘明珠,刘光东,孙捷.中药药烟熏灸联合红光治疗肝经湿热型带状疱疹的临床观察[J].世界中医药,2017,12(12):2964-2967.
[6] 董其坤,王志刚,李文平,等.中西医结合治疗老年带状疱疹的临床研究[J].世界中医药,2017,12(4):790-793.
[7] 陈灏珠.实用内科学[M].12版.北京:人民卫生出版社,2005:378-380.
[8] 刘红华,魏国奇,单筠筠.中医清热利湿法辅助治疗急性带状疱疹30例分析[J].中华危重症医学杂志(电子版),2015,8(3):180-182.
[9] 刘清文,常洪山.中西医结合治疗带状疱疹[J].中医外治杂志,2004,13(5):53.
[10] O’Connor KM,Paauw DS.Herpes zoster[J].Med Clin North Am,2013,97(4):503-522.
[11] Kawai K,Yawn BP.Risk Factors for Herpes Zoster:A Systematic Review and Meta-analysis[J].Mayo Clin Proc,2017,92(12):1806-1821.
[12] Maksimova MY,Sineva NA,Vodopyanov NP.Herpes zoster-induced neuralgia (neuropathy) [J].TerArkh,2014,86(11):93-99.
[13] Dosenovic S,JelicicKadic A,Miljanovic M,et al.Interventions for Neuropathic Pain:An Overview of Systematic Reviews[J].AnesthAnalg,2017,125(2):643-652.
[14] Wang W,Zhao W,Liu Z,et al.Trigeminal neuralgia increases cerebral blood flow in a focal cerebral ischemic model in rats[J].Int J Clin Exp Med,2015,8(4):6544-6552.
[15] Qin ZL,Yang LQ,Li N,et al.Clinical study of cerebrospinal fluid neuropeptides in patients with primary trigeminal neuralgia[J].Clin Neurol Neurosurg,2016,143:111-115.
[16] 陈朋,李红玉.雄黄的临床应用与炮制方法研究进展[J].中华中医药学刊,2014,32(7):1663-1666.
[17] Liu J,Wei LX,Wang Q,et al.A review of cinnabar (HgS) and/or realgar containing traditional medicines[J].J Ethnopharmacol,2018,210:340-350.
[18] 朱坤明,李涛,方磊.单味雄黄粉外敷治疗带状疱疹[J].中国民间疗法,2016,24(7):77.
[19] 李明英,李易霞.外涂自拟雄黄散辅助治疗带状疱疹的运用[J].中国医药指南,2012,10(27):616.
[20] 赵红霞,鞠大宏,刘梅洁,等.五味子有效成分药理学研究进展[J].中国医药导刊,2014,17(10):1334-1336.
[21] Wen Y,Shi Y.Alum:an old dog with new tricks[J].Emerg Microbes Infect,2016,5:e25.
[22] 王耿红.外敷中药治疗老年带状疱疹疗效分析[J].中国现代药物应用,2013,7(19):145.
[2] 包烨华,陶承军,楚佳梅.中镇六穴结合梅花针刺络拔罐治疗带状疱疹后遗神经痛临床观察[J].中华中医药学刊,2010,28(10):2226-2228.
[3] Dayan RR,Peleg R.Herpes zoster-typical and atypical presentations[J].Postgrad Med,2017,129(6):567-571.
[4] 刘春阳,王莒生,刘志勇.针药联合治疗带状疱疹急性期肝经郁热证52例疗效观察[J].中医杂志,2017,58(21):1842-1845.
[5] 刘明珠,刘光东,孙捷.中药药烟熏灸联合红光治疗肝经湿热型带状疱疹的临床观察[J].世界中医药,2017,12(12):2964-2967.
[6] 董其坤,王志刚,李文平,等.中西医结合治疗老年带状疱疹的临床研究[J].世界中医药,2017,12(4):790-793.
[7] 陈灏珠.实用内科学[M].12版.北京:人民卫生出版社,2005:378-380.
[8] 刘红华,魏国奇,单筠筠.中医清热利湿法辅助治疗急性带状疱疹30例分析[J].中华危重症医学杂志(电子版),2015,8(3):180-182.
[9] 刘清文,常洪山.中西医结合治疗带状疱疹[J].中医外治杂志,2004,13(5):53.
[10] O’Connor KM,Paauw DS.Herpes zoster[J].Med Clin North Am,2013,97(4):503-522.
[11] Kawai K,Yawn BP.Risk Factors for Herpes Zoster:A Systematic Review and Meta-analysis[J].Mayo Clin Proc,2017,92(12):1806-1821.
[12] Maksimova MY,Sineva NA,Vodopyanov NP.Herpes zoster-induced neuralgia (neuropathy) [J].TerArkh,2014,86(11):93-99.
[13] Dosenovic S,JelicicKadic A,Miljanovic M,et al.Interventions for Neuropathic Pain:An Overview of Systematic Reviews[J].AnesthAnalg,2017,125(2):643-652.
[14] Wang W,Zhao W,Liu Z,et al.Trigeminal neuralgia increases cerebral blood flow in a focal cerebral ischemic model in rats[J].Int J Clin Exp Med,2015,8(4):6544-6552.
[15] Qin ZL,Yang LQ,Li N,et al.Clinical study of cerebrospinal fluid neuropeptides in patients with primary trigeminal neuralgia[J].Clin Neurol Neurosurg,2016,143:111-115.
[16] 陈朋,李红玉.雄黄的临床应用与炮制方法研究进展[J].中华中医药学刊,2014,32(7):1663-1666.
[17] Liu J,Wei LX,Wang Q,et al.A review of cinnabar (HgS) and/or realgar containing traditional medicines[J].J Ethnopharmacol,2018,210:340-350.
[18] 朱坤明,李涛,方磊.单味雄黄粉外敷治疗带状疱疹[J].中国民间疗法,2016,24(7):77.
[19] 李明英,李易霞.外涂自拟雄黄散辅助治疗带状疱疹的运用[J].中国医药指南,2012,10(27):616.
[20] 赵红霞,鞠大宏,刘梅洁,等.五味子有效成分药理学研究进展[J].中国医药导刊,2014,17(10):1334-1336.
[21] Wen Y,Shi Y.Alum:an old dog with new tricks[J].Emerg Microbes Infect,2016,5:e25.
[22] 王耿红.外敷中药治疗老年带状疱疹疗效分析[J].中国现代药物应用,2013,7(19):145.
© 2004-2018 中国地质图书馆版权所有 京ICP备05064691号 京公网安备11010802017129号 地址：北京市海淀区学院路29号 邮编：100083 电话：办公室：(+86 10)66554848；文献借阅、咨询服务、科技查新：66554700 |