银屑病1号方联合阿维A治疗银屑病血热型临床观察
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摘要
目的:探讨银屑病1号方联合阿维A治疗血热型银屑病的效果。方法:血热型银屑病患者56例,按照随机数字的方法将患者分为对照组和观察组,每组均为28例患者,对照组患者使用阿维A胶囊治疗,观察组患者在对照组患者治疗方法的基础上联合使用银屑病1号方进行治疗,对治疗的效果进行对比。结果:经过治疗后,对照组患者的PASI积分,瘙痒程度评分,分别从(27.46±3.86)分,(4.35±0.86)分,下降到(8.67±1.32)分,(3.63±0.77)分。观察组患者的PASI积分,瘙痒程度评分,分别从(28.13±4.01)分,(4.41±0.75)分,下降到(5.32±1.27)分,(3.14±0.61)分。各项数据的下降幅度均为观察组大于对照组,数据差异均具有统计学意义(t=9.677,2.639,P<0.05),观察组患者的治疗效果优于对照组患者,数据差异具有统计学意义(z=-4.519,P<0.05),两组患者在治疗过程中的各项不良反应数据差异均不具有统计学意义(χ~2=0.352,0.163,2.074,1.077,0.132,P>0.05)。结论:使用银屑病1号方联合阿维A治疗血热型银屑病患者,可以改善患者的症状,提升治疗效果,值得在临床工作中使用。
Objective: To investigate the effect of Psoriasis No.1 combined with acitretin A on blood-heat psoriasis.Methods: Fifty-six patients with psoriasis of blood heat were divided into control group and observation group according to random number.Each group had 28 patients.The patients in the control group were treated with acitretin A capsule and the patients in the observation group were treated with the combination of Liangxue Xiaofeng Decoction on the basis of the treatment method of the control group,and the effect of the treatment was compared.Result: After treatment,PASI scores and pruritus scores in the control group were decreased from( 27.46 ± 3.86) points and( 4.35 ± 0.86) points to( 8.67± 1.32) points and( 3.63 ± 0.77) points,respectively.The PASI scores and pruritus scores in the observation group were dropped from( 28.13 ± 4.01) points and( 4.41 ± 0.75) points to( 5.32 ± 1.27) points and( 3.14 ± 0.61)points,respectively.The decline of each data in the observation group was greater than that of the control group,and the data differences were statistically significant( t = 9.677,2.639,6.367,3.955,P < 0.05).The treatment effect of the observation group was better than that of the control group,and the difference was statistically significant( z =-4.519,P < 0.05).The difference in adverse reaction data between the two groups during the course of treatment was not statistically significant( χ2= 0.352,0.163,2.074,1.077,0.132,P > 0.05).Conclusion: The treatment of blood heat type psoriasis with Psoriasis No.1 combined with acitretin A can improve the symptoms and the therapeutic effect.It is worthy of using in clinical work.
Objective: To investigate the effect of Psoriasis No.1 combined with acitretin A on blood-heat psoriasis.Methods: Fifty-six patients with psoriasis of blood heat were divided into control group and observation group according to random number.Each group had 28 patients.The patients in the control group were treated with acitretin A capsule and the patients in the observation group were treated with the combination of Liangxue Xiaofeng Decoction on the basis of the treatment method of the control group,and the effect of the treatment was compared.Result: After treatment,PASI scores and pruritus scores in the control group were decreased from( 27.46 ± 3.86) points and( 4.35 ± 0.86) points to( 8.67± 1.32) points and( 3.63 ± 0.77) points,respectively.The PASI scores and pruritus scores in the observation group were dropped from( 28.13 ± 4.01) points and( 4.41 ± 0.75) points to( 5.32 ± 1.27) points and( 3.14 ± 0.61)points,respectively.The decline of each data in the observation group was greater than that of the control group,and the data differences were statistically significant( t = 9.677,2.639,6.367,3.955,P < 0.05).The treatment effect of the observation group was better than that of the control group,and the difference was statistically significant( z =-4.519,P < 0.05).The difference in adverse reaction data between the two groups during the course of treatment was not statistically significant( χ2= 0.352,0.163,2.074,1.077,0.132,P > 0.05).Conclusion: The treatment of blood heat type psoriasis with Psoriasis No.1 combined with acitretin A can improve the symptoms and the therapeutic effect.It is worthy of using in clinical work.
引文
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[16] 苏彤,陈宏,李璐,等.寻常性银屑病患者外周血白介素17、白介素23 mRNA的表达及与病情相关性研究[J].中华皮肤科杂志,2014,47(4):278-281.
[17] 龙福泉,刘业强,钱伊弘,等.肿瘤坏死因子α基因启动子多态性与泛发性脓疱性银屑病相关性研究[J].中华皮肤科杂志,2017,50(12):879-882.
[18] 任洁,薛愉,孔宁,等.血清白细胞介素-34在银屑病关节炎骨破坏中的作用研究[J].中华风湿病学杂志,2016,20(10):663-668.
[19] 李继红,李琼仙.阿维A在治疗银屑病过程中对患者血脂水平的影响[J].广东医学,2016,37(8):1223-1227.
[20] 刘盼盼,匡叶红,张江林,等.阿维A与氨甲蝶呤治疗重度斑块型银屑病的疗效[J].中南大学学报(医学版),2016,41(8):804-808.
[21] 黎瑜,蔡兰花,吴艳华,等.中药治疗寻常型银屑病血热证机制研究进展[J].国际中医中药杂志,2018,40(1):82-86.
[22] 李波.白花蛇舌草的化学成分和药理作用研究进展[J].天津药学,2016,28(5):75-78.
[2] 沈跃莉.阿维A胶囊联合紫外线治疗寻常型银屑病的疗效及对T淋巴细胞免疫功能的影响[J].中国医药导刊,2017,19(2):173-175.
[3] 黄小风.银屑病与精神障碍关系的研究进展[J].临床与病理杂志,2017,37(1):184-188.
[4] 朱周,顾丽群,任祺,等.中药银屑病一号方治疗血热型银屑病的疗效观察[J].广州中医药大学学报,2018,35(1):41-45.
[5] 胡薇,王琦.中药贴敷神阙穴不同时间对银屑病患者瘙痒症疗效的观察[J].中国医刊,2017,52(4):107-109.
[6] 李小英.308 nm单频准分子光治疗斑块状银屑病疗效观察[J].广西医学,2017,39(3):408-409.
[7] 戴春燕,赵慧芳,戴长寅,等.卡泊三醇软膏结合卤米松乳膏治疗银屑病的疗效及对患者皮肤屏障功能及血清瘦素、胃饥饿素表达的影响[J].河北医科大学学报,2018,39(1):82-85.
[8] 李慧,张英虎,杨斌,等.养血解毒汤对老年银屑病患者血清免疫细胞因子的调节[J].中国老年学杂志,2015(5):1394-1395.
[9] 赵辨.临床皮肤病学[M].3版.南京:江苏科学技术出版社,2001:759-761.
[10] 国家中医药管理局.中医病证诊断疗效标准[S].南京:南京大学出版社,1994:276-277.
[11] 付曼妮,石年.活血消银片对银屑病患者VEGF水平和PASI指数的影响以及其临床疗效分析[J].中国中西医结合皮肤性病学杂志,2017,16(1):38-40.
[12] 国家中医药管理局.中华人民共和国中医药行业标准·中医皮肤病证诊断疗效标准[S].1995.
[13] 郑筱萸.中药新药临床研究指导原则(试行)[S].北京:中国医药科技出版社,2002:299-302.
[14] 杜华,窦莉莉,陈克明,等.进行期寻常性银屑病患者皮损面积严重度指数与骨代谢的相关性研究[J].实用皮肤病学杂志,2013(6):323-324,327.
[15] 汤雯剑,罗浩,赵金涛,等.银屑病患者血清中 IL-10与 IL-21水平监测的临床应用[J].现代检验医学杂志,2015(2):65-67.
[16] 苏彤,陈宏,李璐,等.寻常性银屑病患者外周血白介素17、白介素23 mRNA的表达及与病情相关性研究[J].中华皮肤科杂志,2014,47(4):278-281.
[17] 龙福泉,刘业强,钱伊弘,等.肿瘤坏死因子α基因启动子多态性与泛发性脓疱性银屑病相关性研究[J].中华皮肤科杂志,2017,50(12):879-882.
[18] 任洁,薛愉,孔宁,等.血清白细胞介素-34在银屑病关节炎骨破坏中的作用研究[J].中华风湿病学杂志,2016,20(10):663-668.
[19] 李继红,李琼仙.阿维A在治疗银屑病过程中对患者血脂水平的影响[J].广东医学,2016,37(8):1223-1227.
[20] 刘盼盼,匡叶红,张江林,等.阿维A与氨甲蝶呤治疗重度斑块型银屑病的疗效[J].中南大学学报(医学版),2016,41(8):804-808.
[21] 黎瑜,蔡兰花,吴艳华,等.中药治疗寻常型银屑病血热证机制研究进展[J].国际中医中药杂志,2018,40(1):82-86.
[22] 李波.白花蛇舌草的化学成分和药理作用研究进展[J].天津药学,2016,28(5):75-78.
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