银杏达莫注射液辅助治疗老年脓毒症患者的临床效果
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摘要
目的探讨银杏达莫注射液辅助治疗老年脓毒症患者的临床效果。方法将48例老年脓毒症患者随机分为观察组25例和对照组23例。两组均给予常规综合治疗,观察组加用银杏达莫注射液治疗。比较两组患者治疗前后急性生理学与慢性健康状况评估Ⅱ(APACHEⅡ)评分,炎症指标及肾功能指标。结果治疗后,两组患者APACHEⅡ评分、白细胞计数、C反应蛋白、血尿素氮、血肌酐、血清胱抑素C水平均较治疗前降低,且观察组以上指标均低于对照组(均P <0. 05)。结论在常规治疗的基础上,银杏达莫可更好地改善老年脓毒症患者的肾功能及临床症状、降低机体炎症反应。
Objective To investigate the clinical efficacy of adjuvant therapy of Ginkgo Leaf Extract and Dipyridamole Injection for elderly patients with sepsis. Methods Forty-eight elderly patients with sepsis were randomly divided into observation group( 25 cases) and control group( 23 cases). Both groups were given conventional comprehensive treatment,and the observation group received additional Ginkgo Leaf Extract and Dipyridamole Injection. Pre-and post-treatment Acute Physiology and Chronic Health Evaluation Ⅱ( APACHEⅡ) scores,inflammation indicators,and renal function indices were compared between the two groups. Results After treatment,APACHEⅡscore,WBC count,C-reactive protein,blood urea nitrogen,serum creatinine,and serum cystatin C levels decreased in both groups compared with those before treatment,and the indices mentioned above in the observation group were lower than those in the control group( all P < 0. 05). Conclusion Based on conventional therapy,ginkgo damole can better improve renal function and clinical symptoms and reduce inflammation response in the body among elderly patients with sepsis.
Objective To investigate the clinical efficacy of adjuvant therapy of Ginkgo Leaf Extract and Dipyridamole Injection for elderly patients with sepsis. Methods Forty-eight elderly patients with sepsis were randomly divided into observation group( 25 cases) and control group( 23 cases). Both groups were given conventional comprehensive treatment,and the observation group received additional Ginkgo Leaf Extract and Dipyridamole Injection. Pre-and post-treatment Acute Physiology and Chronic Health Evaluation Ⅱ( APACHEⅡ) scores,inflammation indicators,and renal function indices were compared between the two groups. Results After treatment,APACHEⅡscore,WBC count,C-reactive protein,blood urea nitrogen,serum creatinine,and serum cystatin C levels decreased in both groups compared with those before treatment,and the indices mentioned above in the observation group were lower than those in the control group( all P < 0. 05). Conclusion Based on conventional therapy,ginkgo damole can better improve renal function and clinical symptoms and reduce inflammation response in the body among elderly patients with sepsis.
引文
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[12]刘建立,逯世林. PCT,CRP和WBC测定对临床感染性疾病的诊断价值[J].临床医药实践,2015,24(11):834-835.
[13] Dellinger RP,Levy MM,Rhodes A,et al. Surviving sepsis campaign:international guidelines for management of severe sepsis and septic shock:2012[J]. Crit Care Med,2013,41(2):580-637.
[2] Bagshaw SM,George C,Bellomo R,et al. Early acute kidney injury and sepsis:a multicentre evaluation[J]. Crit Care,2008,12(2):R47.
[3] Sood MM,Shafer LA,Ho J,et al. Early reversible acute kidney injury is associated with improved survival in septic shock[J].J Crit Care,2014,29(5):711-717.
[4] Pisoni R,Wille KM,Tolwani AJ. The epidemiology of severe acute kidney injury:from BEST to PICARD,in acute kidney injury:new concepts[J]. Nephron Clin Pmct,2008,109(4):c188-c191.
[5] Daher EF,Marques CN,Lima RS,et al. Acute kidney injury in an infectious disease intensive care unit-an assessment of prognostic factors[J]. Swiss Med Wkly,2008,138(9/10):128-133.
[6]王晓文,张晓林,徐元华,等.氯沙坦联合银杏达莫治疗早期糖尿病肾病疗效观察[J].现代中西医结合杂志,2010,19(31):3 393-3 394.
[7] Wang HE,Shapiro NI,Safford MM,et al. High-sensitivity C-reactive protein and risk of sepsis[J]. PLo S One,2013,8(7):e69232.
[8] Knaus WA,Draper EA,Wagner DP,et al. APACHEⅡ:a severity of disease classification system[J]. Crit Care Med,1985,13(10):818-829.
[9]王雁,杨义芳.银杏叶的药理作用及其机制的研究进展[J].中国现代应用药学,2001,11(1):1-4.
[10]苏艳丽,王红,张淑文,等.中药芪参活血颗粒在重度脓毒症治疗中的作用[J].首都医科大学学报,2009,30(1):27-31.
[11]陈维洲,张培智.银杏叶提取物的药理和临床研究进展(上)[J].中国新药与临床杂志,1999,18(5):315-317.
[12]刘建立,逯世林. PCT,CRP和WBC测定对临床感染性疾病的诊断价值[J].临床医药实践,2015,24(11):834-835.
[13] Dellinger RP,Levy MM,Rhodes A,et al. Surviving sepsis campaign:international guidelines for management of severe sepsis and septic shock:2012[J]. Crit Care Med,2013,41(2):580-637.