冠心病与贫血的相关关系研究进展
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摘要
冠心病与贫血都是老年人群常见病,且诸多研究证实两者在病因学和病理学方面相互影响、共同促进,在老龄化加剧的当今社会中成为越来越突出的问题。本文从流行病学特征的相似性、共同影响因素及共有发病机制等方面总结了冠心病与贫血之间可能存在的内在联系,并针对我国冠心病合并贫血患者的发病现状对其临床防治提供几点建议,有助于冠心病患者积极纠正贫血,改善预后。
Both coronary heart disease and anemia are common diseases of the elderly, and many studies have confirmed that they affect each other in terms of etiology and pathology, and jointly promote each others′ development,which has become more and more prominent problems in the aging society today. In this article, we summarize the possible internal relations between coronary heart disease and anemia from the aspects of similarity of epidemiological characteristics, common influencing factors and common pathogenesis, etc. In view of the present situation of anemia associated with coronary heart disease in China, some suggestions for clinical prevention and treatment are presented in this article, and we believed that positive correction of anemia with coronary heart disease could improve the prognosis of patients.
Both coronary heart disease and anemia are common diseases of the elderly, and many studies have confirmed that they affect each other in terms of etiology and pathology, and jointly promote each others′ development,which has become more and more prominent problems in the aging society today. In this article, we summarize the possible internal relations between coronary heart disease and anemia from the aspects of similarity of epidemiological characteristics, common influencing factors and common pathogenesis, etc. In view of the present situation of anemia associated with coronary heart disease in China, some suggestions for clinical prevention and treatment are presented in this article, and we believed that positive correction of anemia with coronary heart disease could improve the prognosis of patients.
引文
[1]胡盛寿,孔灵芝.中国心血管报告2005[M].北京:中国大百科全书出版社,2006:1-44.
[2]Konduracka E,Gajos G.Clinical characteristics of elderly patients with heart failure:what else do we need to know?[J].Pol Arch Med Wewn,2016,126(78):463-464.
[3]Taylor S,Rampton D.Treatment of iron deficiency anemia:practical considerations[J].Pol Arch Med Wewn,2015,125(6):452-460.
[4]McLean E,Cogswell M,Egli I,et al.Worldwide prevalence of anaemia,WHO Vitamin and Mineral Nutrition Information System,1993-2005[J].Public Health Nutr,2009,12(4):444-454.
[5]方唯一,施鸿毓.急性冠状动脉综合征与贫血[J].心肺血管病杂志,2007,8(26):182-183.
[6]Weiss G.Iron metabolism in the anemia of chronic disease[J].Biochim Biophys Acta,2009,1790(7):682-693.
[7]Krack A,Sharma R,Figulla HR,et al.The importance of the gastrointestinal system in the pathogenesis of heart failure[J].Eur Heart J,2005,26(22):2368-2374.
[8]Wen-Ni LI,Zhang CB,Wang JL,et al.Effect of Tongmai Yangxin Pill on the Serum Hepcidin Level of Patients with Coronary Atherosclerotic Heart Disease and Anemia of Chronic Disease[J].Progress in Modern Biomedicine,2017,90(17):82-93.
[9]Rymer JA,Rao SV.Anemia and coronary artery disease:pathophysiology,prognosis,and treatment[J].Coronary Artery Dis,2017,29(2):1-5.
[10]Patel B,Assaad M,Tolia S,et al.Mild anemia as a possible cause of false positive stress echocardiography in non-obstructive coronary artery disease:A pathophysiologic hypothesis[J].Int J Cardiol,2016,203(25):525-526.
[11]Kalra PR,Greenlaw N,Ferrari R,et al.Hemoglobin and Change in Hemoglobin Status Predict Mortality,Cardiovascular Events and Bleeding in Stable Coronary Artery Disease[J].Am J Med,2017,130(6):667-671.
[12]Sabe MA,Claggett B,Burdmann EA,et al.Coronary Artery Disease Is a Predictor of Progression to Dialysis in Patients With Chronic Kidney Disease,Type 2 Diabetes Mellitus,and Anemia:魦An Analysis of the Trial to Reduce Cardiovascular Events With Aranesp Therapy(TREAT)[J]J Am Heart Assoc,2016,5(4):2850-2856.
[13]Salisbury AC.Marker or mediator?Is the link between anemia and outcomes in patients with coronary artery disease growing any clearer?[J].J Thorac Dis,2015,7(12):640-649.
[14]Burney S,Ahmed SQ,Zafar SI.Premature coronary heart disease in a young adult-pernicious anemia the underlying culprit:a case report[J].Pak Armed Forces Med J,2015,65:297-298.
[15]Hudak L,Jaraisy A,Haj S,et al.An updated systematic review and meta analysis on the association between Helicobacter pylori infection and iron deficiency anemia[J]Helicobacter,2016,22(1):512-519.
[16]Sai E,Shimada K,Miyauchi K,et al.Increased cystatin C levels as a risk factor of cardiovascular events in patients with preserved estimated glomerular filtration rate after elective percutaneous coronary intervention with drugeluting stents[J].Heart Vessels,2016,31(5):694-701.
[17]Hung SH,Lin HC,Chung SD.Association between venous thromboembolism and iron-deficiency anemia:a population-based study[J].Blood Coagul Fibrinolysis,2015,26(4):368.
[18]Li S,Fonarow GC,Mukamal KJ,et al.Sex and Race/Ethnicity-Related Disparities in Care and Outcomes After Hospitalization for Coronary Artery Disease Among Older Adults[J].Circ Cardiovasc Qual Outcomes,2016,9(1):36-45.
[19]Lee SH,Jeong MH,Han KR,et al.Comparison of Transradial and Transfemoral Approaches for Percutaneous Coronary Intervention in Patients With?Acute Coronary Syndrome and Anemia[J].Am J Cardiol,2016,117(10):1582-1587.
[20]Huang YH,Ho-Chang K,Huang FC,et al.Hepcidin-Induced Iron Deficiency Is Related to Transient Anemia and Hypoferremia in Kawasaki Disease Patients[J].Int JMol Sci,2016,17(5):715-720.
[21]Mozos I.Mechanisms Linking Red Blood Cell Disorders and Cardiovascular Diseases[J].Biomed Res Int,2015,15(33):682-689.
[22]Tsai I,Wang CP,Lu YC,et al.The burden of major adverse cardiac events in patients with coronary artery disease[J].Bmc Cardiovascular Disorders,2017,17(1):1-8.
[23]Naschitz JE,Yeshurun D,Abrahamson J,et al.Ischemic heart disease precipitated by occult cancer[J].Cancer,2015,69(11):2712-2720.
[24]Albuquerque IMD,Garlet AB,Cardoso DM,et al.Relationship between functional class and left ventricular ejection fraction in patients with coronary heart disease who were candidates for cardiac rehabilitation[J].Scientia Medica,2017,27(55):449-452.
[25]丁德良,李环波.尿毒症患者C反应蛋白与贫血、营养不良及冠心病的关系[J].实用医学杂志,2006,22(17):2026-2027.
[26]冀晓红,李健成,杨娜.缺铁性贫血与老年冠心病发生及严重程度的关系[J].中国老年学杂志,2016,36(16):3955-3957.
[27]赵媛媛,王林,宋芳,等.冠心病慢性心力衰竭患者贫血与心功能关系的研究[J].天津医药,2011,39(4):306-308.
[28]陈艳梅,裴志勇,周东翠,等.老年冠心病患者贫血与左室舒张功能不全的相关性[J].浙江临床医学,2014(3):395-396.
[29]赵建全,唐萍,向睿.缺铁性贫血与老年冠心病患者冠状动脉影像学特点的分析[J].内蒙古医学杂志,2014,46(2):1922-1924.
[30]李少玲,王海滨.冠心病慢性心力衰竭住院患者贫血与心功能间的关联性评价[J].中国医药指南,2016,14(25):167-168.
[2]Konduracka E,Gajos G.Clinical characteristics of elderly patients with heart failure:what else do we need to know?[J].Pol Arch Med Wewn,2016,126(78):463-464.
[3]Taylor S,Rampton D.Treatment of iron deficiency anemia:practical considerations[J].Pol Arch Med Wewn,2015,125(6):452-460.
[4]McLean E,Cogswell M,Egli I,et al.Worldwide prevalence of anaemia,WHO Vitamin and Mineral Nutrition Information System,1993-2005[J].Public Health Nutr,2009,12(4):444-454.
[5]方唯一,施鸿毓.急性冠状动脉综合征与贫血[J].心肺血管病杂志,2007,8(26):182-183.
[6]Weiss G.Iron metabolism in the anemia of chronic disease[J].Biochim Biophys Acta,2009,1790(7):682-693.
[7]Krack A,Sharma R,Figulla HR,et al.The importance of the gastrointestinal system in the pathogenesis of heart failure[J].Eur Heart J,2005,26(22):2368-2374.
[8]Wen-Ni LI,Zhang CB,Wang JL,et al.Effect of Tongmai Yangxin Pill on the Serum Hepcidin Level of Patients with Coronary Atherosclerotic Heart Disease and Anemia of Chronic Disease[J].Progress in Modern Biomedicine,2017,90(17):82-93.
[9]Rymer JA,Rao SV.Anemia and coronary artery disease:pathophysiology,prognosis,and treatment[J].Coronary Artery Dis,2017,29(2):1-5.
[10]Patel B,Assaad M,Tolia S,et al.Mild anemia as a possible cause of false positive stress echocardiography in non-obstructive coronary artery disease:A pathophysiologic hypothesis[J].Int J Cardiol,2016,203(25):525-526.
[11]Kalra PR,Greenlaw N,Ferrari R,et al.Hemoglobin and Change in Hemoglobin Status Predict Mortality,Cardiovascular Events and Bleeding in Stable Coronary Artery Disease[J].Am J Med,2017,130(6):667-671.
[12]Sabe MA,Claggett B,Burdmann EA,et al.Coronary Artery Disease Is a Predictor of Progression to Dialysis in Patients With Chronic Kidney Disease,Type 2 Diabetes Mellitus,and Anemia:魦An Analysis of the Trial to Reduce Cardiovascular Events With Aranesp Therapy(TREAT)[J]J Am Heart Assoc,2016,5(4):2850-2856.
[13]Salisbury AC.Marker or mediator?Is the link between anemia and outcomes in patients with coronary artery disease growing any clearer?[J].J Thorac Dis,2015,7(12):640-649.
[14]Burney S,Ahmed SQ,Zafar SI.Premature coronary heart disease in a young adult-pernicious anemia the underlying culprit:a case report[J].Pak Armed Forces Med J,2015,65:297-298.
[15]Hudak L,Jaraisy A,Haj S,et al.An updated systematic review and meta analysis on the association between Helicobacter pylori infection and iron deficiency anemia[J]Helicobacter,2016,22(1):512-519.
[16]Sai E,Shimada K,Miyauchi K,et al.Increased cystatin C levels as a risk factor of cardiovascular events in patients with preserved estimated glomerular filtration rate after elective percutaneous coronary intervention with drugeluting stents[J].Heart Vessels,2016,31(5):694-701.
[17]Hung SH,Lin HC,Chung SD.Association between venous thromboembolism and iron-deficiency anemia:a population-based study[J].Blood Coagul Fibrinolysis,2015,26(4):368.
[18]Li S,Fonarow GC,Mukamal KJ,et al.Sex and Race/Ethnicity-Related Disparities in Care and Outcomes After Hospitalization for Coronary Artery Disease Among Older Adults[J].Circ Cardiovasc Qual Outcomes,2016,9(1):36-45.
[19]Lee SH,Jeong MH,Han KR,et al.Comparison of Transradial and Transfemoral Approaches for Percutaneous Coronary Intervention in Patients With?Acute Coronary Syndrome and Anemia[J].Am J Cardiol,2016,117(10):1582-1587.
[20]Huang YH,Ho-Chang K,Huang FC,et al.Hepcidin-Induced Iron Deficiency Is Related to Transient Anemia and Hypoferremia in Kawasaki Disease Patients[J].Int JMol Sci,2016,17(5):715-720.
[21]Mozos I.Mechanisms Linking Red Blood Cell Disorders and Cardiovascular Diseases[J].Biomed Res Int,2015,15(33):682-689.
[22]Tsai I,Wang CP,Lu YC,et al.The burden of major adverse cardiac events in patients with coronary artery disease[J].Bmc Cardiovascular Disorders,2017,17(1):1-8.
[23]Naschitz JE,Yeshurun D,Abrahamson J,et al.Ischemic heart disease precipitated by occult cancer[J].Cancer,2015,69(11):2712-2720.
[24]Albuquerque IMD,Garlet AB,Cardoso DM,et al.Relationship between functional class and left ventricular ejection fraction in patients with coronary heart disease who were candidates for cardiac rehabilitation[J].Scientia Medica,2017,27(55):449-452.
[25]丁德良,李环波.尿毒症患者C反应蛋白与贫血、营养不良及冠心病的关系[J].实用医学杂志,2006,22(17):2026-2027.
[26]冀晓红,李健成,杨娜.缺铁性贫血与老年冠心病发生及严重程度的关系[J].中国老年学杂志,2016,36(16):3955-3957.
[27]赵媛媛,王林,宋芳,等.冠心病慢性心力衰竭患者贫血与心功能关系的研究[J].天津医药,2011,39(4):306-308.
[28]陈艳梅,裴志勇,周东翠,等.老年冠心病患者贫血与左室舒张功能不全的相关性[J].浙江临床医学,2014(3):395-396.
[29]赵建全,唐萍,向睿.缺铁性贫血与老年冠心病患者冠状动脉影像学特点的分析[J].内蒙古医学杂志,2014,46(2):1922-1924.
[30]李少玲,王海滨.冠心病慢性心力衰竭住院患者贫血与心功能间的关联性评价[J].中国医药指南,2016,14(25):167-168.