基于透明质酸的抗肿瘤药物载体研究进展
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摘要
透明质酸是细胞外基质的主要成分之一,具有良好的生物相容性、可生物降解性、非免疫原性,分子结构中还富含可供进一步化学修饰改性的羧基、羟基等反应性功能基团,近年来已成为设计和制备抗肿瘤药物递送载体的原材料。此外,透明质酸的CD44受体在许多肿瘤细胞表面均为高表达状态,以透明质酸为原材料制备的抗肿瘤药物载体对CD44高表达的肿瘤细胞具有主动靶向性。本文对基于透明质酸设计的前体药物(前药)、有机载体材料(胶束、脂质体、纳米颗粒、微泡、水凝胶等)和无机复合载体材料(纳米金、量子点、碳纳米管、二氧化硅)等抗肿瘤药物载体进行了综述。
Hyaluronic acid(HA) is the main component of the extracellular matrix(ECM) and is widely used in anticancer drug delivery. It is biocompatible, biodegradable, non-toxic, non-immunogenic and rich of carboxyl, hydroxyl function groups. Moreover, cancer cells have increased number of HA receptors in contrast to normal cells. Thus, the antitumor drug delivery system prepared with hyaluronic acid has active targeting for the high CD44-expressing tumor cells. In this paper, the research progress of antitumor drug carriers based on hyaluronic acid was summarized in the field of prodrugs, organic carrier materials(micelles, liposomes, nanoparticles, microbubbles, hydrogels, etc.), and inorganic composite carrier materials(nano gold, quantum dots, carbon nanotubes, silicon dioxide, etc.).
Hyaluronic acid(HA) is the main component of the extracellular matrix(ECM) and is widely used in anticancer drug delivery. It is biocompatible, biodegradable, non-toxic, non-immunogenic and rich of carboxyl, hydroxyl function groups. Moreover, cancer cells have increased number of HA receptors in contrast to normal cells. Thus, the antitumor drug delivery system prepared with hyaluronic acid has active targeting for the high CD44-expressing tumor cells. In this paper, the research progress of antitumor drug carriers based on hyaluronic acid was summarized in the field of prodrugs, organic carrier materials(micelles, liposomes, nanoparticles, microbubbles, hydrogels, etc.), and inorganic composite carrier materials(nano gold, quantum dots, carbon nanotubes, silicon dioxide, etc.).
引文
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