肿瘤数据库系统在肺癌研究中的应用
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摘要
近年来,我国肺癌的发病率和死亡率持续增高,严重危害国民健康。随着计算机信息技术、数据挖掘的高速发展,世界各地建立大量临床数据库,已收集、存储和管理数量日益庞大、种类日益繁多的肺癌相关资料,为肺癌研究提供宝贵而丰富的数据来源。本研究介绍了目前全球部分常用的肿瘤数据库,并列举其在肺癌研究方面的应用,为肺癌研究应用数据库提供思路。比较美国国立癌症研究所的"监测,流行病学和结果"数据库(surveillance, epidemiology and end results database, SEER)和美国国家癌症数据库(National Cancer Data Base, NCDB)的不同点,介绍了我国肿瘤数据库的发展现状,为我国乃至全球的肿瘤数据的发展提出展望。
引文
[1] Allemani C,Matsuda T,Di Carlo V,et al.Global surveillance of trends in cancer survival 2000-14(CONCORD-3):analysis of individual records for 37 513 025 patients diagnosed with one of 18 cancers from 322 population-based registries in 71 countries[J].Lancet,2018,391(10125):1023-1075.
[2] Wang BY,Huang JY,Cheng CY,et al.Lung cancer and prognosis in taiwan:a population-based cancer registry[J].J Thorac Oncol,2013,8(9):1128-1135.
[3] Harris JP,Murphy JD,Hanlon AL,et al.A population-based comparative effectiveness study of radiationtherapy techniques in stage Ⅲ non-small cell lung cancer[J].Int J Radiat Oncol Biol Phys,2014,88(4):872-884.
[4] Kawaguchi T,Matsumura A,Fukai S,et al.Japanese ethnicity compared with Caucasian ethnicity and never-smoking status are independent favorable prognostic factors for overall survival in non-small cell lung cancer:a collaborative epidemiologic study of the National Hospital Organization Study Group for Lung Cancer (NHSGLC) in Japan and a Southern California Regional Cancer Registry databases[J].J Thorac Oncol,2010,5(7):1001-1010.
[5] Shi R,Diaz R,Shi Z,et al.The effect of poayer status on survival of patients with stage Ⅰ/Ⅱ non-small cell lung cancer:NCDB 1998-2011[J].Anticancer Res,2016,36(1):319-326.
[6] 汪鹏,吴昊,罗阳,等.医疗大数据应用需求分析与平台建设构想[J].中国医院管理,2015,35(6):40-42.
[7] Flanagan MR,Varghese TK Jr,Backhus LM,et al.Gaps in guideline-concordant use of diagnostic tests among lung cancer patients[J].Ann Thorac Surg,2015,100(6):2006-2012.
[8] Lally BE,Hu JJ,Koniaris L.Reply to the influence of Hispanic ethnicity on nonsmall cell lung cancer histology and patient survival:an analysis of the survival,epidemiology,and end results database[J].Cancer,2013,119(6):1287-1288.
[9] Khakwani A,Rich AL,Tata LJ,et al.Small-cell lung cancer in England:trends in survival and chemotherapy using the National Lung Cancer Audit[J].PLoS One,2014,9(2):e89426.
[10] Harlos C,Musto G,Lambert P,et al.Androgen pathway manipulation and survival in patients with lungcancer[J].Horm Cancer,2015,6(2-3):120-127.
[11] 徐志伟,杨永光,刘海洋,等.中国人群肺癌危险因素的Meta分析[J].中国实用医刊,2017,44(24):122-126.
[12] Jakobsen E,Rasmussen TR.The danish lung cancer registry[J].Clin Epidemiol,2016,8:537-541.
[13] Simonsen DF,Farkas DK,S gaard M,et al.Tuberculosis and risk of cancer:a Danish nationwide cohort study[J].Int J Tuberc Lung Dis,2014,18(10):1211-1219.
[14] Cheng CL,Kao YH,Lin SJ,et al.Validation of the National Health Insurance Research Database with ischemic stroke cases in Taiwan[J].Pharmacoepidemiol Drug Saf,2011,20(3):236-242.
[15] Lin TY,Huang WY,Lin JC,et al.Increased lung cancer risk among patients with pneumococcal pneumonia:a nationwide population-based cohort study[J].Lung,2014,192(1):159-165.
[16] 赵威,李恩有,刘珊珊,等.肺癌诊断方法的比较与研究进展[J].现代生物医学进展,2016,16(9):1766-1768.
[17] Aberle DR,Adams AM,Berg CD,et al.Reduced lung-cancer mortality with low-dose computed tomographic screening[J].N Engl J Med,2011,365(5):395-409.
[18] Tammem?gi MC.Application of risk prediction models to lung cancer screening:a review[J].J Thorac Imaging,2015,30(2):88-100.
[19] 叶波,赵珩.第八版国际肺癌TNM分期修订稿解读[J].中国肺癌杂志,2016,19(6):337-342.
[20] Rami-Porta R,Bolejack V,Crowley J,et al.The IASLC lung cancer staging project:proposals for the revisions of the T descriptors in the forthcoming eighth edition of the TNM classification for lung cancer[J].J Thorac Oncol,2015,10(7):990-1003.
[21] Armato SG,McLennan G,Bidaut L,et al.The lung image database consortium (LIDC) and image database resource initiative (IDRI):a completed reference database of lung nodules on CT scans[J].Med Phys,2011,38(2):915-931.
[22] Ng G,Song Y,Cai W,et al.Hierarchical and binary spatial descriptors for lung nodule image retrieval[J].Conf Proc IEEE Eng Med Biol Soc,2014,2014:6463-6466.
[23] Magee MJ.Database Audit in Thoracic Surgery[J].Thorac Surg Clin,2017,27(3):291-296.
[24] Jacobs JP,O′Brien SM,Pasquali SK,et al.Variation in outcomes for benchmark operations:an analysis of the Society of Thoracic Surgeons Congenital Heart Surgery Database[J].Ann Thorac Surg,2011,92(6):2184-2191.
[25] Fernandez FG,Kosinski AS,Burfeind W,et al.STS lung cancer resection risk model:higher quality data and superior outcomes[J].Ann Thora Surg,2016,102(2):370.
[26] Jean RA,DeLuzio MR,Kraev AI,et al.Analyzing risk kactors for morbidity and mortality after lung resection for lung cancer using the NSQIP database[J].J Am Coll Surg,2016,222(6):992-1000.
[27] Samson P,Robinson CG,Bradley J,et al.The National surgical quality improvement program risk calculator does not adequately stratify risk for patients with clinical stage I non-small cell lung cancer[J].J Thorac Cardiovasc Surg,2016,151(3):697-705.
[28] Kühnl A,Hocaoglu Y,Herzog M,et al.The university of munich lung cancer group database:design,profile of cohort and outcome analysis[J].Eur J Med Res,2007,12(10):520-526.
[29] Kelly K,Chansky K,Mack PC,et al.Chemotherapy outcomes by histologic subtypes of non-small-celllung cancer:analysis of the southwest oncology group database for antimicrotubule-platinum therapy[J].Clin Lung Cancer,2013,14(6):627-635.
[30] Khakwani A,Jack RH,Vernon S,et al.Apples and pears A comparison of two sources of national lung cancer audit data in England[J].ERJ Open Res,2017,3(3):00003-02017.
[31] Salazar MC,Rosen JE,Arnold BN,et al.Adjuvant chemotherapy for T3 non-small cell lung cancer with additional tumor nodules in the same Lobe[J].J Thorac Oncol,2016,11(7):1090-1100.
[32] Owonikoko TK,Ragin C,Chen Z,et al.Real-world effectiveness of systemic agents approved for advanced non-small cell lung cancer:A SEER-medicare analysis[J].Oncologist,2013,18(5):600-610.
[33] Mazières J,Pujol JL,Kalampalikis N,et al.Perception of lung cancer among the general population and comparison with other cancers[J].J Thorac Oncol,2015,10(3):420-425.
[34] Iyen-Omofoman B,Hubbard RB,Smith CJ,et al.The distribution of lung cancer across sectors of society in the United Kingdom:a study using national primary care data[J].BMC Public Health,2011,11:857.
[35] SEER.About the SEER Registries[EB/OL].[2018-08-15].https://seer.cancer.gov/registries/index.html.
[36] 章鸣嬛,陈瑛,汪城,等.美国国立癌症研究所SEER数据库概述及应用[J].微型电脑应用,2015,31(12):26-28,32,5.
[37] Liang W,He J,Shen Y,et al.Impact of examined lymph node count on precise staging and long-term survival of resected non-small-cell lung cancer:a population study of the US SEER database and a chinese multi-institutional registry[J].J Clin Oncol,2017,35(11):1162-1170.
[38] Urban D,Bar J,Solomon B,et al.Lymph node ratio may predict the benefit of postoperative radiotherapy in non-small-cell lung cancer[J].J Thorac Oncol,2013,8(7):940-946.
[39] Raval MV,Bilimoria KY,Stewart AK,et al.Using the NCDB for cancer care improvement:anintroduction to available quality assessment tools[J].J Surg Oncol,2009,99(8):488-490.
[40] National Cancer Database.About the National Cancer Database[EB/OL].[2018-08-15].https://www.facs.org/quality-programs/cancer/ncdb/about.
[41] Hancock J,Rosen J,Moreno A,et al.Management of clinical stage ⅢA primary lung cancers in the National Cancer Database[J].Ann Thorac Surg,2014,98(2):424-432.
[42] Boffa DJ,Hancock JG,Yao X,et al.Now or later:evaluating the importance of chemotherapy timing in resectable stage Ⅲ(N2) lung cancer in the National Cancer Database[J].Ann Thorac Surg,2015,99(1):200-208.
[43] Boffa DJ,Rosen JE,Mallin K,et al.Using the national cancer database for outcomes research:a review[J].JAMA Oncol,2017,3(12):1722-1728.
[44] Reips UD.International journal of internet science[J].Inter J Internet Sci,2012,7(1):78-89.
[45] 魏矿荣,梁智恒,刘静,等.中国肿瘤登记简史[J].中华医史杂志,2012,42(1):21-25.
[46] 赵丹.在线肺癌病例数据库的构建和初步应用[D].上海:第二军医大学,2013.
[47] Anom.中国首家“肿瘤精准医学大数据中心”在津成立[J].肿瘤防治研究,2016,43(2):167.
[2] Wang BY,Huang JY,Cheng CY,et al.Lung cancer and prognosis in taiwan:a population-based cancer registry[J].J Thorac Oncol,2013,8(9):1128-1135.
[3] Harris JP,Murphy JD,Hanlon AL,et al.A population-based comparative effectiveness study of radiationtherapy techniques in stage Ⅲ non-small cell lung cancer[J].Int J Radiat Oncol Biol Phys,2014,88(4):872-884.
[4] Kawaguchi T,Matsumura A,Fukai S,et al.Japanese ethnicity compared with Caucasian ethnicity and never-smoking status are independent favorable prognostic factors for overall survival in non-small cell lung cancer:a collaborative epidemiologic study of the National Hospital Organization Study Group for Lung Cancer (NHSGLC) in Japan and a Southern California Regional Cancer Registry databases[J].J Thorac Oncol,2010,5(7):1001-1010.
[5] Shi R,Diaz R,Shi Z,et al.The effect of poayer status on survival of patients with stage Ⅰ/Ⅱ non-small cell lung cancer:NCDB 1998-2011[J].Anticancer Res,2016,36(1):319-326.
[6] 汪鹏,吴昊,罗阳,等.医疗大数据应用需求分析与平台建设构想[J].中国医院管理,2015,35(6):40-42.
[7] Flanagan MR,Varghese TK Jr,Backhus LM,et al.Gaps in guideline-concordant use of diagnostic tests among lung cancer patients[J].Ann Thorac Surg,2015,100(6):2006-2012.
[8] Lally BE,Hu JJ,Koniaris L.Reply to the influence of Hispanic ethnicity on nonsmall cell lung cancer histology and patient survival:an analysis of the survival,epidemiology,and end results database[J].Cancer,2013,119(6):1287-1288.
[9] Khakwani A,Rich AL,Tata LJ,et al.Small-cell lung cancer in England:trends in survival and chemotherapy using the National Lung Cancer Audit[J].PLoS One,2014,9(2):e89426.
[10] Harlos C,Musto G,Lambert P,et al.Androgen pathway manipulation and survival in patients with lungcancer[J].Horm Cancer,2015,6(2-3):120-127.
[11] 徐志伟,杨永光,刘海洋,等.中国人群肺癌危险因素的Meta分析[J].中国实用医刊,2017,44(24):122-126.
[12] Jakobsen E,Rasmussen TR.The danish lung cancer registry[J].Clin Epidemiol,2016,8:537-541.
[13] Simonsen DF,Farkas DK,S gaard M,et al.Tuberculosis and risk of cancer:a Danish nationwide cohort study[J].Int J Tuberc Lung Dis,2014,18(10):1211-1219.
[14] Cheng CL,Kao YH,Lin SJ,et al.Validation of the National Health Insurance Research Database with ischemic stroke cases in Taiwan[J].Pharmacoepidemiol Drug Saf,2011,20(3):236-242.
[15] Lin TY,Huang WY,Lin JC,et al.Increased lung cancer risk among patients with pneumococcal pneumonia:a nationwide population-based cohort study[J].Lung,2014,192(1):159-165.
[16] 赵威,李恩有,刘珊珊,等.肺癌诊断方法的比较与研究进展[J].现代生物医学进展,2016,16(9):1766-1768.
[17] Aberle DR,Adams AM,Berg CD,et al.Reduced lung-cancer mortality with low-dose computed tomographic screening[J].N Engl J Med,2011,365(5):395-409.
[18] Tammem?gi MC.Application of risk prediction models to lung cancer screening:a review[J].J Thorac Imaging,2015,30(2):88-100.
[19] 叶波,赵珩.第八版国际肺癌TNM分期修订稿解读[J].中国肺癌杂志,2016,19(6):337-342.
[20] Rami-Porta R,Bolejack V,Crowley J,et al.The IASLC lung cancer staging project:proposals for the revisions of the T descriptors in the forthcoming eighth edition of the TNM classification for lung cancer[J].J Thorac Oncol,2015,10(7):990-1003.
[21] Armato SG,McLennan G,Bidaut L,et al.The lung image database consortium (LIDC) and image database resource initiative (IDRI):a completed reference database of lung nodules on CT scans[J].Med Phys,2011,38(2):915-931.
[22] Ng G,Song Y,Cai W,et al.Hierarchical and binary spatial descriptors for lung nodule image retrieval[J].Conf Proc IEEE Eng Med Biol Soc,2014,2014:6463-6466.
[23] Magee MJ.Database Audit in Thoracic Surgery[J].Thorac Surg Clin,2017,27(3):291-296.
[24] Jacobs JP,O′Brien SM,Pasquali SK,et al.Variation in outcomes for benchmark operations:an analysis of the Society of Thoracic Surgeons Congenital Heart Surgery Database[J].Ann Thorac Surg,2011,92(6):2184-2191.
[25] Fernandez FG,Kosinski AS,Burfeind W,et al.STS lung cancer resection risk model:higher quality data and superior outcomes[J].Ann Thora Surg,2016,102(2):370.
[26] Jean RA,DeLuzio MR,Kraev AI,et al.Analyzing risk kactors for morbidity and mortality after lung resection for lung cancer using the NSQIP database[J].J Am Coll Surg,2016,222(6):992-1000.
[27] Samson P,Robinson CG,Bradley J,et al.The National surgical quality improvement program risk calculator does not adequately stratify risk for patients with clinical stage I non-small cell lung cancer[J].J Thorac Cardiovasc Surg,2016,151(3):697-705.
[28] Kühnl A,Hocaoglu Y,Herzog M,et al.The university of munich lung cancer group database:design,profile of cohort and outcome analysis[J].Eur J Med Res,2007,12(10):520-526.
[29] Kelly K,Chansky K,Mack PC,et al.Chemotherapy outcomes by histologic subtypes of non-small-celllung cancer:analysis of the southwest oncology group database for antimicrotubule-platinum therapy[J].Clin Lung Cancer,2013,14(6):627-635.
[30] Khakwani A,Jack RH,Vernon S,et al.Apples and pears A comparison of two sources of national lung cancer audit data in England[J].ERJ Open Res,2017,3(3):00003-02017.
[31] Salazar MC,Rosen JE,Arnold BN,et al.Adjuvant chemotherapy for T3 non-small cell lung cancer with additional tumor nodules in the same Lobe[J].J Thorac Oncol,2016,11(7):1090-1100.
[32] Owonikoko TK,Ragin C,Chen Z,et al.Real-world effectiveness of systemic agents approved for advanced non-small cell lung cancer:A SEER-medicare analysis[J].Oncologist,2013,18(5):600-610.
[33] Mazières J,Pujol JL,Kalampalikis N,et al.Perception of lung cancer among the general population and comparison with other cancers[J].J Thorac Oncol,2015,10(3):420-425.
[34] Iyen-Omofoman B,Hubbard RB,Smith CJ,et al.The distribution of lung cancer across sectors of society in the United Kingdom:a study using national primary care data[J].BMC Public Health,2011,11:857.
[35] SEER.About the SEER Registries[EB/OL].[2018-08-15].https://seer.cancer.gov/registries/index.html.
[36] 章鸣嬛,陈瑛,汪城,等.美国国立癌症研究所SEER数据库概述及应用[J].微型电脑应用,2015,31(12):26-28,32,5.
[37] Liang W,He J,Shen Y,et al.Impact of examined lymph node count on precise staging and long-term survival of resected non-small-cell lung cancer:a population study of the US SEER database and a chinese multi-institutional registry[J].J Clin Oncol,2017,35(11):1162-1170.
[38] Urban D,Bar J,Solomon B,et al.Lymph node ratio may predict the benefit of postoperative radiotherapy in non-small-cell lung cancer[J].J Thorac Oncol,2013,8(7):940-946.
[39] Raval MV,Bilimoria KY,Stewart AK,et al.Using the NCDB for cancer care improvement:anintroduction to available quality assessment tools[J].J Surg Oncol,2009,99(8):488-490.
[40] National Cancer Database.About the National Cancer Database[EB/OL].[2018-08-15].https://www.facs.org/quality-programs/cancer/ncdb/about.
[41] Hancock J,Rosen J,Moreno A,et al.Management of clinical stage ⅢA primary lung cancers in the National Cancer Database[J].Ann Thorac Surg,2014,98(2):424-432.
[42] Boffa DJ,Hancock JG,Yao X,et al.Now or later:evaluating the importance of chemotherapy timing in resectable stage Ⅲ(N2) lung cancer in the National Cancer Database[J].Ann Thorac Surg,2015,99(1):200-208.
[43] Boffa DJ,Rosen JE,Mallin K,et al.Using the national cancer database for outcomes research:a review[J].JAMA Oncol,2017,3(12):1722-1728.
[44] Reips UD.International journal of internet science[J].Inter J Internet Sci,2012,7(1):78-89.
[45] 魏矿荣,梁智恒,刘静,等.中国肿瘤登记简史[J].中华医史杂志,2012,42(1):21-25.
[46] 赵丹.在线肺癌病例数据库的构建和初步应用[D].上海:第二军医大学,2013.
[47] Anom.中国首家“肿瘤精准医学大数据中心”在津成立[J].肿瘤防治研究,2016,43(2):167.
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