Six1蛋白在恶性肿瘤中的研究进展
摘要
Six1是同源盒基因家族中的成员,与胚胎细胞发育和器官分化有关,促进细胞分化前的前体细胞增殖和生存。Cyclin D1、Cyclin A1和c-myc在细胞生长和增殖中起着至关重要的作用,Six1通过这些蛋白可调控细胞周期。文献报道,Six1通过组织、血液系统及阶段依赖等多种方式调节癌细胞启动、增殖和转移,在肿瘤发生、发展中发挥重要作用。该文总结Six1蛋白在恶性肿瘤发生、发展中的作用及其分子机制研究进展,Six1有可能成为抑制肿瘤生长的靶点。
引文
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[15]Coletta R D,Christensen K L,Micalizzi D S,et al.Six1 overexpression in mammary cells induces genomic instability and is sufficient for malignant transformation[J].Cancer Res,2008,68(7):2204-13.
[16]Sehic D,Karlsson J,Sandstedt B,et al.SIX1 protein expression selectively identifies blastemal elements in Wilms tumor[J].Pediatr Blood Cancer,2012,59(1):62-8.
[17]Ono H,Imoto I,Kozaki K,et al.SIX1 promotes epithelial-mesenchymal transition in colorectal cancer through ZEB1 activation[J].Oncogene,2012,31(47):4923-34.
[18]Zheng X H,Liang P H,Guo J X,et al.Expression and clinical implications of homeobox gene Six1 in cervical cancer cell lines and cervical epithelial tissues[J].Int J Gynecol Cancer,2010,20(9):1587-92.
[19]Tan J,Zhang C,Qian J.Expression and significance of Six1 and Ezrin in cervical cancer tissue[J].Tumour Biol,2011,32(6):1241-7.
[20]谢柏臻,陈安民,郭风劲,等.RNAi下调Six1基因对人骨肉瘤细胞增殖和转移能力的影响[J].中国癌症杂志,2008,18(8):561-1
[21]熊光宜,王瑞林,王艳霞,等.Ezrin蛋白在软骨肉瘤中的表达及其意义[J].临床与实验病理学杂志,2011,27(5):56-8.
[22]Micalizzi D S,Christensen K L,Jedlicka P,et al.The Six1 homeoprotein induces human mammary carcinoma cells to undergo epithelial-mesenchymal transition and metastasis in mice through increasing TGF-beta signaling[J].J Clin Invest,2009,119(9):2678-90.
[23]Micalizzi D S,Wang C A,Farabaugh S M,et al.Homeoprotein Six1 increases TGF-beta typeⅠreceptor and converts TGF-beta signaling from suppressive to supportive for tumor growth[J].Cancer Res,2010,70(24):10371-80.
[24]Martin K J,Graner E,Li Y,et al.High-sensitivity array analysis of gene expression for the early detection of disseminated breast tumor cells in peripheral blood[J].Proc Natl Acad Sci USA,2001,98(5):2646-51.
[25]Wang C A,Jedlicka P,Patrick A N,et al.SIX1 induces lymphangiogenesis and metastasis via upregulation of VEGF-C in mouse models of breast cancer[J].J Clin Invest,2012,122(5):1895-906.
[2]Yu Y Y,Pan Y S,Zhu Z G.Homeobox genes and their functions on development and neoplasm in gastrointestinal tract[J].Eur J Surg Oncol,2007,33(2):129-32.
[3]Reichenberger K J,Coletta R D,Schulte A P,et al.Gene amplification is a mechanism of Six1 overexpression in breast cancer[J].Cancer Res,2005,65(7):2668-75.
[4]Behbakht K,Qamar L,Aldridge C S,et al.Six1 overexpression in ovarian carcinoma causes resistance to TRAIL-mediated apoptosis and is associated with poor survival[J].Cancer Res,2007,67(7):3036-42.
[5]Ng K T,Man K,Sun C K,et al.Clinicopathological significance of homeoprotein Six1 in hepatocellular carcinoma[J].Br J Cancer,2006,95(8):1050-5.
[6]Yu Y,Khan J,Khanna C,et al.Expression profiling identifies the cytoskeletal organizer ezrin and the developmental homeoprotein Six-1 as key metastatic regulators[J].Nat Med,2004,10(2):175-81.
[7]Wan F,Miao X,Quraishi I,et al.Gene expression changes during HPV-mediated carcinogenesis:a comparison between an in vitro cell model and cervical cancer[J].Int J Cancer,2008,123(1):32-40.
[8]Li C M,Guo M,Borczuk A,Powell C A,et al.Gene expression in Wilms’tumor mimics the earliest committed stage in the metanephric mesenchymal-epithelial transition[J].Am J Pathol,2002,160(6):2181-90.
[9]Kawakami K,Sato S,Ozaki H,et al.Six family genes-structure and function astranscription factors and their roles in development[J].Bioessays,2000,22(7):616-26.
[10]Silver S J,Rebay L.Signaling cireuitries in development:insights from the retinal determination gene network[J].Development,2005,132(1):3-13.
[11]Ozaki H,Nakamura K,Funahashi J,et al.Six1 controls patterning of the mouse otic vesicle[J].Development,2004,131(3):551-62.
[12]Christensen K L,Brennan J D,Aldridge C S,et al.Cell cycle regulation of the human Six1 homeoprotein is mediated by APC(Cdh1)[J].Oncogene,2007,26(23):3406-14.
[13]Coletta R D,Christensen K,Reichenberger K J,et al.The Six1homeoprotein stimulates tumorigenesis by reactivation of Cyclin A1[J].Proc Natl Acad Sci USA,2004,101(17):6478-83.
[14]Yu Y,Davicioni E,Triche T J,et al.The homeoprotein six1 transcriptionally activates multiple protumorigenic genes but requires ezrin to promote metastasis[J].Cancer Res,2006,66(4):1982-9.
[15]Coletta R D,Christensen K L,Micalizzi D S,et al.Six1 overexpression in mammary cells induces genomic instability and is sufficient for malignant transformation[J].Cancer Res,2008,68(7):2204-13.
[16]Sehic D,Karlsson J,Sandstedt B,et al.SIX1 protein expression selectively identifies blastemal elements in Wilms tumor[J].Pediatr Blood Cancer,2012,59(1):62-8.
[17]Ono H,Imoto I,Kozaki K,et al.SIX1 promotes epithelial-mesenchymal transition in colorectal cancer through ZEB1 activation[J].Oncogene,2012,31(47):4923-34.
[18]Zheng X H,Liang P H,Guo J X,et al.Expression and clinical implications of homeobox gene Six1 in cervical cancer cell lines and cervical epithelial tissues[J].Int J Gynecol Cancer,2010,20(9):1587-92.
[19]Tan J,Zhang C,Qian J.Expression and significance of Six1 and Ezrin in cervical cancer tissue[J].Tumour Biol,2011,32(6):1241-7.
[20]谢柏臻,陈安民,郭风劲,等.RNAi下调Six1基因对人骨肉瘤细胞增殖和转移能力的影响[J].中国癌症杂志,2008,18(8):561-1
[21]熊光宜,王瑞林,王艳霞,等.Ezrin蛋白在软骨肉瘤中的表达及其意义[J].临床与实验病理学杂志,2011,27(5):56-8.
[22]Micalizzi D S,Christensen K L,Jedlicka P,et al.The Six1 homeoprotein induces human mammary carcinoma cells to undergo epithelial-mesenchymal transition and metastasis in mice through increasing TGF-beta signaling[J].J Clin Invest,2009,119(9):2678-90.
[23]Micalizzi D S,Wang C A,Farabaugh S M,et al.Homeoprotein Six1 increases TGF-beta typeⅠreceptor and converts TGF-beta signaling from suppressive to supportive for tumor growth[J].Cancer Res,2010,70(24):10371-80.
[24]Martin K J,Graner E,Li Y,et al.High-sensitivity array analysis of gene expression for the early detection of disseminated breast tumor cells in peripheral blood[J].Proc Natl Acad Sci USA,2001,98(5):2646-51.
[25]Wang C A,Jedlicka P,Patrick A N,et al.SIX1 induces lymphangiogenesis and metastasis via upregulation of VEGF-C in mouse models of breast cancer[J].J Clin Invest,2012,122(5):1895-906.