牙龈卟啉单胞菌fimA分型与相关疾病的研究
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摘要
牙龈卟啉单胞菌与牙周组织感染、糖尿病、冠状动脉粥样硬化性心脏病(简称冠心病)等疾病的发生发展密切相关。菌毛是牙龈卟啉单胞菌重要的毒力因子,可以协助牙龈卟啉单胞菌黏附和入侵宿主细胞。根据FimA蛋白编码基因fimA核苷酸序列的不同可将其分为Ⅰ、Ⅰb、Ⅱ、Ⅲ、Ⅳ和Ⅴ等6种基因型,不同fimA基因型菌株的致病力和与疾病的相关性有一定差异。本文重点综述近年来不同fimA基因型牙龈卟啉单胞菌菌毛与相关疾病的研究进展。
Porphyromonas gingivalis(P.gingivalis)is involved in the occurrence and development of various diseases including periodontal tissue infections,diabetes,coronary heart disease,and etc.Fimbriae is an important virulence factor of P.gingivalis and can assist it to adhere and invade host cells.P.gingivalis strains are classified into six types based on divergent nucleotide sequences of the fimA gene(typesⅠ,Ⅰb,Ⅱ,Ⅲ,Ⅳ,and Ⅴ).The pathogenicity of P.gingivalis strains with different fimA genotypes was different.This review focuses on the recent progress in the study of different fimA genotypes and related diseases of P.gingivalis fimbriae.
Porphyromonas gingivalis(P.gingivalis)is involved in the occurrence and development of various diseases including periodontal tissue infections,diabetes,coronary heart disease,and etc.Fimbriae is an important virulence factor of P.gingivalis and can assist it to adhere and invade host cells.P.gingivalis strains are classified into six types based on divergent nucleotide sequences of the fimA gene(typesⅠ,Ⅰb,Ⅱ,Ⅲ,Ⅳ,and Ⅴ).The pathogenicity of P.gingivalis strains with different fimA genotypes was different.This review focuses on the recent progress in the study of different fimA genotypes and related diseases of P.gingivalis fimbriae.
引文
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[14] Krishnan M,Krishnan P,Chandrasekaran SC.Detection of Porphyromonas gingivalis fimA typeⅠgenotype in gingivitis by Real-time PCR-a pilot study[J].J Clin Diagn Res,2016,10(6)∶ZC32-ZC35
[15] R89as IN,Siqueira JF.Distribution of Porphyromonas gingivalis fimA genotypes in primary endodontic infections[J].Oral Surg Oral Med Oral Pathol Oral Radiol Endod,2010,109(3)∶474-478
[16] Wang Q,Zhou X,Zheng Q,et al.Distribution of Porphyromonas gingivalis fimA genotypes in chronic apical periodontitis associated with symptoms[J].J Endod,2010,36(11)∶1790-1795
[17]唐路,曹日丹,曾红燕.牙龈卟啉单胞菌菌毛fimA基因型在牙周牙髓联合病变中的分布[J].北京口腔医学,2015,23(6)∶321-324
[18]唐路,薛栋,白雨豪,等.颈动脉粥样硬化斑块中牙龈卟啉单胞菌菌毛fimA基因型的分布研究[J].现代口腔医学杂志,2017,31(6)∶321-325
[19] Ziver T,Balci A,Ergin S,et al.The role of Porphyromonas gingivalis in the development of atherosclerosis and its relationship with fimA genotype[J].Clin Lab,2014,11(12)∶1
[20] Nakano K,Inaba H,Nomura R,et al.Distribution of Porphyromonas gingivalis fimA genotypes in cardiovascular specimens from Japanese patients[J].Oral Microbiol Immunol,2008,23(2)∶170-172
[21] Pathirana RD,O'Brien-Simpson NM,Reynolds EC.Host immune responses to Porphyromonas gingivalis,antigens[J].Periodontol 2000,2010,52(1)∶218-237
[22] Ziver T,Balci A,Ergin S,et al.The role of Porphyromonas gingivalis in the development of atherosclerosis and its relationship with fim A genotype[J].Clin Lab,2014,60(7)∶1225-1232
[2] Amano A.Bacterial adhesins to host components in periodontitis[J].Periodontol 2000,2010,52(1)∶12-37
[3] Hasegawa Y,Nagano K,Ikai R,et al.Localization and function of the accessory protein Mfa3in Porphyromonas gingivalis Mfa1fimbriae[J].Mol Oral Microbiol,2013,28(6)∶467-480
[4] Hasegawa Y,Murakami Y.Porphyromonas gingivalis fimbriae:Recent developments describing the function and localization of mfa1gene cluster proteins[J].J Oral Biosci,2014,56(3)∶86-90
[5] Kristoffersen AK,Solli SJ,Nguyen TD,et al.Association of the rgpB gingipain genotype to the major fimbriae(fimA)genotype in clinical isolates of the periodontal pathogen Porphyromonas gingivalis[J].J Oral Microbio,2015,7∶29124
[6] Miura M,Hamachi T,Fujise O,et al.The prevalence and pathogenic differences of Porphyromonas gingivalis fimA genotypes in patients with aggressive periodontitis[J].J Periodontal Res,2005,40(2)∶147-152
[7] Feng X,Zhang L,Xu L,et al.Detection of eight periodontal microorganisms and distribution of Porphyromonas gingivalis fimA genotypes in Chinese patients with aggressive periodontitis[J].J Periodontol,2014,85(1)∶150-159
[8] Fabrizi S,Len R,Blanc V,et al.Variability of the fimA gene in Porphyromonas gingivalis isolated from periodontitis and non-periodontitis patients[J].Med Oral Patol Oral Cir Bucal,2013,18(1)∶e100
[9] Hayashi F,Okada M,Oda Y,et al.Prevalence of Porphyromonas gingivalis fimA genotypes in Japanese children[J].J Oral Sci,2012,54(1)∶77-83
[10] Perez-Chaparro PJ,Rouillon A,Minet J,et al.fimA genotypes and PFGE profile patterns in Porphyromonas gingivalis isolates from subjects with periodontitis[J].Oral Microbiol Immunol,2010,24(5)∶423-426
[11]杨炳涛,徐菁玲,和璐,等.伴糖尿病牙周炎患者牙龈卟啉单胞菌FimA基因型的检测[J].中华口腔医学杂志,2016,51(1)∶20-24
[12]李彦君,潘亚萍,陈旭,等.不同fimA基因型牙龈卟啉单胞菌在青春期龈炎患者中的分布[J].口腔医学研究,2012,28(6)∶556-559
[13] Pan S,Liu Y,Si Y,et al.Prevalence of fimA genotypes of Porphyromonas gingivalis in adolescent orthodontic patients[J].PLoS One,2017,12(11)∶e0188420
[14] Krishnan M,Krishnan P,Chandrasekaran SC.Detection of Porphyromonas gingivalis fimA typeⅠgenotype in gingivitis by Real-time PCR-a pilot study[J].J Clin Diagn Res,2016,10(6)∶ZC32-ZC35
[15] R89as IN,Siqueira JF.Distribution of Porphyromonas gingivalis fimA genotypes in primary endodontic infections[J].Oral Surg Oral Med Oral Pathol Oral Radiol Endod,2010,109(3)∶474-478
[16] Wang Q,Zhou X,Zheng Q,et al.Distribution of Porphyromonas gingivalis fimA genotypes in chronic apical periodontitis associated with symptoms[J].J Endod,2010,36(11)∶1790-1795
[17]唐路,曹日丹,曾红燕.牙龈卟啉单胞菌菌毛fimA基因型在牙周牙髓联合病变中的分布[J].北京口腔医学,2015,23(6)∶321-324
[18]唐路,薛栋,白雨豪,等.颈动脉粥样硬化斑块中牙龈卟啉单胞菌菌毛fimA基因型的分布研究[J].现代口腔医学杂志,2017,31(6)∶321-325
[19] Ziver T,Balci A,Ergin S,et al.The role of Porphyromonas gingivalis in the development of atherosclerosis and its relationship with fimA genotype[J].Clin Lab,2014,11(12)∶1
[20] Nakano K,Inaba H,Nomura R,et al.Distribution of Porphyromonas gingivalis fimA genotypes in cardiovascular specimens from Japanese patients[J].Oral Microbiol Immunol,2008,23(2)∶170-172
[21] Pathirana RD,O'Brien-Simpson NM,Reynolds EC.Host immune responses to Porphyromonas gingivalis,antigens[J].Periodontol 2000,2010,52(1)∶218-237
[22] Ziver T,Balci A,Ergin S,et al.The role of Porphyromonas gingivalis in the development of atherosclerosis and its relationship with fim A genotype[J].Clin Lab,2014,60(7)∶1225-1232