猪圆环病毒研究进展
摘要
猪圆环病毒属于圆环病毒科圆环病毒属,病毒粒子为二十面体对称结构,无囊膜,单股负链DNA,基因大小约2 000 bp,是现在已知最小的动物病毒之一。本文就近年国内外报道的猪圆环病毒(PCV1、PCV2、PCV3)的病原学、分子流行病学、致病机理、临床诊断方法以及防控等方面进行综述,以期为PCV诊断和防治等提供一定参考。
引文
[1]TISCHER I,RASCHUR,TOCHTENMANN G.Characterization of papovavirusand picornavirus-like particles in permanent pig kidney cell lines[J].Zentralbl Bakteriol,1974,226:153-167.
[2]CLARK E G.Post-weaning multisystemic wasting syndrome[J].Proceeding of the Ameri-can Association of Swine Practitioners,1997,28:499-501.
[3]Meehan B M,Mcneilly F,Todd D,et al.Characterization of novel circovirus DNAs associated with wasting syndromes in pigs[J].Journal of General Virology,1998,79(Pt9)(9):2171.
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[8]LIU J,CHEN I,DU Q,et al.The ORF3protein of porcine circovirustype 2 is involved in viral pathogenesis in vivo[J].J Virol,2006,80(10):5065-5073.
[9]代振江,王伟丞,曾智勇,等.猪圆环病毒基因组结构与功能研究进展[J].畜牧与兽医,2016,48(3):151-154.
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[16]李富强,王利丽,李秀丽.猪圆环病毒2型分子生物学研究进展[J].天津农业科学,2015,21(9):57-60.
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[18]Bao F,Mi S,Luo Q,et al.Retrospective study of porcine circovirus type 2 infection reveals a novel genotype PCV2f.[J].Transboundary&Emerging Diseases,2017,65(3):432-440.
[19]YANG N,L1 J,YANG Q,et al.Reduced antigen presentation capability and modified inflammatory/immuno suppressivecytokine expression of induced monocyte-derived dendritic cells from peripheral blood of piglets infected with porcine circovirus type 2[J].Archives of virology,2018May;163(5):1231-1239.
[20]LI D,WANG J,XU S,et al.Identification and functional analysis of the novel ORF6protein of porcine circovirus type2 in vitro[J].Veterinary research communications,2018 Mar,42(1):1-10.
[21]HUANG Y L,PANG V F,LIN C M,et al.Porcinecircovius type 2(PCV2)infection decreases the efficacy of an attenuated classicalswine fever virus(CSFV)vaccine[J].Vet Res,2011b,42(1):115.
[22]LIN H X,MA Z,YANG X Q,et al.A novel vaccine against porcine circovirus type 2(PCV2)and Streptococcus equissp.zooepidemicus(SEZ)co-infection[J].Vet Microbiol,2014,171(1/2):198-205.
[23]湛洋,王东亮,王乃东,等.猪圆环病毒3型检测及其Cap结构序列和抗原性预测分析[J].畜牧兽医学报,2017,48(6):1076-1084.
[24]PALINSKI R,PINEYRO P,SHANG P,et al.A Novel Porcine Circovirus Distantly Related to Known Circoviruses Is Associated with Porcine Dermatitis and Nephropathy Syndrome and Reproductive Failure[J].J Virol,2016,91(1):16.
[25]STADEJEK T,WOZNIAK A,MILEK D,et al.First detection of porcine circovirus type 3on commercial pig farms in Poland[J].Transbound Emerg Dis,2017,64(5):1350-1353.
[26]FACCINI S,BARBIERI I,GILIOLI A,et al.Detection and genetic characterization of Porcine circovirus type 3 in Italy[J].Transbound Emerg Dis,2017,64(6):1661-1664.
[27]TOCTHETTO C,LIMA D A,VARELA APM,et al.Full-Genome Sequence of Porcine Circovirus type3 recovered from serum of sows with stillbirths in Brazil.Transbound EmergDis[J],2017,12:1 5.
[28]刘远佳,余伟权,李刚,等.新型圆环病毒—PCV3研究进展及展望(2017)[J].猪业科学,2017,34(5):105-106.
[29]X.Ku,咸文,梁海英,等.猪圆环病毒3型的鉴定与遗传特征分析[J].猪业科学,2017,34(7):32-33.
[30]FU X,FANG B,MA J,et al.Insights into the epidemic characteristics and evolutionary history of the novel porcine circovirus type 3 in southern China[J].Transboundary and emerging diseases,2018 Apr,65(2):296-303.
[31]KIM H R,PARK Y R,LIM D R,et al.Multiplex real-time polymerase chain reaction for the differential detection of porcine circovirus 2 and 3[J].J Virol Methods,2017,250:11-16.
[32]WANG J,ZHANG Y,WANGJ,et al.Development of a TaqMan-based real-time PCR assay for the specific detection of porcine circovirus 3[J].J Virol Methods,2017,248:177-180.
[33]WANG J,ZHANG Y,ZHANG R,et al.Recombinase polymerase amplification assay for rapid detection of porcine circovirus 3[J].Mol Cell Probes,2017,36:58-61.
[34]DENG J,LI X,ZHENG D D,et al.Establishment and application of an indirect ELISA for porcine circovirus3[J].Arch Virol,2017:1-4.
[35]ZHANG L,LUO Y,LIANG L,et al.Phylogenetic analysis of porcine circovirus type 3 and porcine circovirus type 2 in China detected by duplex nanoparticleassisted PCR.Infection,genetics and evolution[J].journal of molecular epidemiology and evolutionary genetics in infectious diseases,2018Jun;60:1-6.
[36]LI X,QIAO M,SUN M,et al.A Duplex Real-Time PCR Assay for the Simultaneous Detection of Porcine Circovirus 2 and Circovirus3[J].Virologica Sinica,2018,33(2):1-6.
[2]CLARK E G.Post-weaning multisystemic wasting syndrome[J].Proceeding of the Ameri-can Association of Swine Practitioners,1997,28:499-501.
[3]Meehan B M,Mcneilly F,Todd D,et al.Characterization of novel circovirus DNAs associated with wasting syndromes in pigs[J].Journal of General Virology,1998,79(Pt9)(9):2171.
[4]PHAN T G,GIANNITTI F,ROSSOW S,et al.Detection of a novel circovirus PCV3 in pigs with cardiac and multisystemic inflammation[J].Virol J,2016,13(1):184.
[5]FENAUX M,OPRIESSNING T,HALBVUR P G,et al.A chimeric porcine circovius(PCV)with the immunogenic capsid gene of the pathogenic PCV type 2(PCV2)cloned into the genomic backbone of the nonpathogenic PCV1 induces protective immunity against PCV2infection in pigs[J].J Virol2004Jun;78(12):6297-303.
[6]邵小雪,杨倩,孟凡伟,等.嵌合猪圆环病毒的构建[J].北京农学院学报,2016,31(1):55-59.
[7]Florence Faurez,邱文英,猪圆环病毒的复制[J].中国畜牧兽医,2009(,10):187.
[8]LIU J,CHEN I,DU Q,et al.The ORF3protein of porcine circovirustype 2 is involved in viral pathogenesis in vivo[J].J Virol,2006,80(10):5065-5073.
[9]代振江,王伟丞,曾智勇,等.猪圆环病毒基因组结构与功能研究进展[J].畜牧与兽医,2016,48(3):151-154.
[10]RO SELL C,SEG ALES J,R AMOSVAR A J A,et al.Identification of porcine circovirus in tissues of pigs with porcine dermatitis and nephropathy syndrome[J].Veterinary Record Journal of the British Veterinary Association,2000,146(2):40.
[11]SAHA D,LEFEBVRE D J,VAN D J,et al.Pathologic and virologic findings in midgestational porcine foetuses after experimental inoculation with PCV2a or PCV2b[J].Veterinary M ic r obiolo gy,2010,145(1-2):62.
[12]郎洪武,张广川,吴发权,等.断奶猪多系统衰弱综合征血清抗体检测[J].中国兽医科技,2000,30(3):3-5.
[13]NIELSEN E O,EN E C,JORSAL S E,et al.Postweaningmultisystemic wasting syndrome in Danish pig herds:productivity,clinical signs and pathology.[J].Veterinary Record Journal of the British Veterinary Association,2008,162(16):505.
[14]MCNEILLY F,MCNAIR I,O'CONNOR M,et al.Evaluation of a porcine circovirus type2-specific antigen-capture enzyme-linked immunosorbent assay for the diagnosis of postweaningmultisystemic wasting syndrome in pigs:comparison with virus isolation,immunohistochemistry,and the polymerase chain re[J].Journal of Veterinary Diagnostic Investigation Official Publication of the American Association of Veterinary Laboratory Diagnosticians Inc,2002,14(2):106.
[15]OKUDA Y,ONO M,YAZAWA S,et al.Experimental reproduction of postweaningmultisystemic wasting syndrome in cesareanderived,colostrum-deprived piglets inoculated with porcine circovirus type 2(PCV2):investigation of quantitative PCV2 distribution and antibody responses[J].Journal of Veterinary Diagnostic Investigation Official Publication of the American Association of Veterinary Laboratory Diagnosticians Inc,2003,15(2):107.
[16]李富强,王利丽,李秀丽.猪圆环病毒2型分子生物学研究进展[J].天津农业科学,2015,21(9):57-60.
[17]DUPONT K,NIELSEN E O,BAEKBO P,et al.Genomic analysis of PCV2 isolates from Danish archives and a current PMWS case-control study supports a shift in genotypes with time[J].Vet Microbiol,2008,128(1-2):56-64.
[18]Bao F,Mi S,Luo Q,et al.Retrospective study of porcine circovirus type 2 infection reveals a novel genotype PCV2f.[J].Transboundary&Emerging Diseases,2017,65(3):432-440.
[19]YANG N,L1 J,YANG Q,et al.Reduced antigen presentation capability and modified inflammatory/immuno suppressivecytokine expression of induced monocyte-derived dendritic cells from peripheral blood of piglets infected with porcine circovirus type 2[J].Archives of virology,2018May;163(5):1231-1239.
[20]LI D,WANG J,XU S,et al.Identification and functional analysis of the novel ORF6protein of porcine circovirus type2 in vitro[J].Veterinary research communications,2018 Mar,42(1):1-10.
[21]HUANG Y L,PANG V F,LIN C M,et al.Porcinecircovius type 2(PCV2)infection decreases the efficacy of an attenuated classicalswine fever virus(CSFV)vaccine[J].Vet Res,2011b,42(1):115.
[22]LIN H X,MA Z,YANG X Q,et al.A novel vaccine against porcine circovirus type 2(PCV2)and Streptococcus equissp.zooepidemicus(SEZ)co-infection[J].Vet Microbiol,2014,171(1/2):198-205.
[23]湛洋,王东亮,王乃东,等.猪圆环病毒3型检测及其Cap结构序列和抗原性预测分析[J].畜牧兽医学报,2017,48(6):1076-1084.
[24]PALINSKI R,PINEYRO P,SHANG P,et al.A Novel Porcine Circovirus Distantly Related to Known Circoviruses Is Associated with Porcine Dermatitis and Nephropathy Syndrome and Reproductive Failure[J].J Virol,2016,91(1):16.
[25]STADEJEK T,WOZNIAK A,MILEK D,et al.First detection of porcine circovirus type 3on commercial pig farms in Poland[J].Transbound Emerg Dis,2017,64(5):1350-1353.
[26]FACCINI S,BARBIERI I,GILIOLI A,et al.Detection and genetic characterization of Porcine circovirus type 3 in Italy[J].Transbound Emerg Dis,2017,64(6):1661-1664.
[27]TOCTHETTO C,LIMA D A,VARELA APM,et al.Full-Genome Sequence of Porcine Circovirus type3 recovered from serum of sows with stillbirths in Brazil.Transbound EmergDis[J],2017,12:1 5.
[28]刘远佳,余伟权,李刚,等.新型圆环病毒—PCV3研究进展及展望(2017)[J].猪业科学,2017,34(5):105-106.
[29]X.Ku,咸文,梁海英,等.猪圆环病毒3型的鉴定与遗传特征分析[J].猪业科学,2017,34(7):32-33.
[30]FU X,FANG B,MA J,et al.Insights into the epidemic characteristics and evolutionary history of the novel porcine circovirus type 3 in southern China[J].Transboundary and emerging diseases,2018 Apr,65(2):296-303.
[31]KIM H R,PARK Y R,LIM D R,et al.Multiplex real-time polymerase chain reaction for the differential detection of porcine circovirus 2 and 3[J].J Virol Methods,2017,250:11-16.
[32]WANG J,ZHANG Y,WANGJ,et al.Development of a TaqMan-based real-time PCR assay for the specific detection of porcine circovirus 3[J].J Virol Methods,2017,248:177-180.
[33]WANG J,ZHANG Y,ZHANG R,et al.Recombinase polymerase amplification assay for rapid detection of porcine circovirus 3[J].Mol Cell Probes,2017,36:58-61.
[34]DENG J,LI X,ZHENG D D,et al.Establishment and application of an indirect ELISA for porcine circovirus3[J].Arch Virol,2017:1-4.
[35]ZHANG L,LUO Y,LIANG L,et al.Phylogenetic analysis of porcine circovirus type 3 and porcine circovirus type 2 in China detected by duplex nanoparticleassisted PCR.Infection,genetics and evolution[J].journal of molecular epidemiology and evolutionary genetics in infectious diseases,2018Jun;60:1-6.
[36]LI X,QIAO M,SUN M,et al.A Duplex Real-Time PCR Assay for the Simultaneous Detection of Porcine Circovirus 2 and Circovirus3[J].Virologica Sinica,2018,33(2):1-6.